公开(公告)号：US20080188726A1

公开(公告)日：2008-08-07

申请号：US11815668

申请日：2006-02-09

申请人： Cristian Presura ,  Antonius Hermanus Maria Akkermans ,  Carsten Heinks ,  Marijn Christian Damstra ,  Daniela Tache

发明人： Cristian Presura ,  Antonius Hermanus Maria Akkermans ,  Carsten Heinks ,  Marijn Christian Damstra ,  Daniela Tache

IPC分类号： A61B5/1468

CPC分类号： A61B5/0261 ,  A61B5/7257

摘要： The present invention relates to a method for measuring blood flow in living tissue and a device for performing the method. The device comprises a laser and a photo sensor. The laser is arranged to illuminate (10) the tissue in such a way that a portion of the light beam, scattered by the tissue, re-enters the laser in order to obtain a self-mixing effect. The resulting light, that is registered (11) as an electric signal by the photo sensor, contains a speckle pattern that is depending on blood cell movement in the tissue. A Fourier transform is applied (12) to this signal and an exponential fit is applied (13) to the resulting frequency domain spectrum. Thereby parameters corresponding to the amount of blood cells and the average velocity of these cells may be obtained.

摘要翻译： 本发明涉及一种测定生物体组织中的血流量的方法和实施该方法的装置。 该装置包括激光和光传感器。 激光被布置成照亮（10）组织，使得被组织散射的光束的一部分重新进入激光器以获得自混合效果。 由光传感器注册（11）作为电信号的结果光包含取决于组织中的血细胞运动的散斑图案。 对该信号进行傅里叶变换（12），并对所得到的频域光谱进行指数拟合（13）。 从而可以获得与血细胞量相对应的参数和这些细胞的平均速度。

公开(公告)号：US08723532B2

公开(公告)日：2014-05-13

申请号：US12995202

申请日：2009-06-10

申请人： Ronald Jan Asjes ,  Adrianus Petrus Johanna Maria Rommers ,  Henricus Antonius Verspaget ,  Cristian Presura ,  Antonius Hermanus Maria Blom

发明人： Ronald Jan Asjes ,  Adrianus Petrus Johanna Maria Rommers ,  Henricus Antonius Verspaget ,  Cristian Presura ,  Antonius Hermanus Maria Blom

IPC分类号： G01R27/26 ,  G01N27/22

CPC分类号： G01N27/221 ,  G01R27/2605 ,  H03K17/955 ,  H03K2217/960775

摘要： A capacitive proximity device for sensing a presence and/or absence of an object in the proximity of an electronic device includes an emission electrode capacitively coupled to a receiver electrode, an oscillator for generating an emission-signal being an alternating electric field between the emission electrode and the receiving electrode, and a sensing circuit connected to the receiving electrode. The sensing circuit receives a measured-signal from the receiver electrode and includes a first synchronous detection circuit together with a low-pass filter for generating an output-signal being proportional to a distance between the object and the electronic device. The sensing circuit further includes a noise-suppresser for reducing noise from the measured-signal before entering the first synchronous detection circuit.

摘要翻译： 用于感测电子设备附近的物体的存在和/或不存在的电容式接近装置包括电容耦合到接收器电极的发射电极，用于产生发射信号的振荡器，所述发射信号是发射电极之间的交变电场 和接收电极，以及连接到接收电极的感测电路。 感测电路从接收器电极接收测量信号，并且包括第一同步检测电路和低通滤波器，用于产生与物体和电子设备之间的距离成比例的输出信号。 感测电路还包括用于在进入第一同步检测电路之前降低来自测量信号的噪声的噪声抑制器。

公开(公告)号：US08417307B2

公开(公告)日：2013-04-09

申请号：US12679966

申请日：2008-09-24

申请人： Cristian Presura ,  Carsten Heinks ,  Olaf Such ,  Gary Nelson Garcia Molina ,  Gert Hooft

发明人： Cristian Presura ,  Carsten Heinks ,  Olaf Such ,  Gary Nelson Garcia Molina ,  Gert Hooft

IPC分类号： A61B5/1455 ,  A61B5/02

CPC分类号： A61B5/14551 ,  A61B5/721

摘要： The invention relates to a blood oximeter for measuring the oxygenation and at least one other parameter of flowing blood in living tissue. According to the invention, the blood oximeter comprises two lightsources (2, 3) emitting light of different wavelengths into tissue, and preferably a light detector (4) for detecting a transmitted and/or reflected part of the light emitted into the tissue, wherein at least one of the light sources is a laser with a laser cavity emitting a laser beam, the laser being adapted to allow a part of the laser beam which is scattered by the tissue to re-enter into the laser cavity, and wherein a laser beam sensor (7, 8) for measuring the light emitted from the laser is provided, the laser beam sensor (7, 8), thus, obtaining a signal which varies in accordance with the self-mixing interferometric effect between the original laser beam and the scattered laser beam. Accordingly, such a blood oximeter is provided that performs well at low perfusion and which further allows for reliable measurements.

摘要翻译： 本发明涉及一种血氧计，用于测量活组织中血液的氧合和至少一种其它参数。 根据本发明，血液计包括将不同波长的光发射到组织中的两个光源（2,3），并且优选地包括用于检测发射到组织中的光的透射和/或反射部分的光检测器（4），其中 光源中的至少一个是具有发射激光束的激光腔的激光器，所述激光器适于允许被组织散射的激光束的一部分重新进入激光腔，并且其中激光器 提供了用于测量从激光发射的光的光束传感器（7,8），激光束传感器（7,8）获得根据原始激光束与原始激光束之间的自混合干涉效应而变化的信号 分散的激光束。 因此，提供了这样一种在低灌注下表现良好并且进一步允许可靠测量的血液计。

公开(公告)号：US20100240973A1

公开(公告)日：2010-09-23

申请号：US12679966

申请日：2008-09-24

申请人： Cristian Presura ,  Carsten Heinks ,  Olaf Such ,  Gary N. Garcia Molina ,  Gert Hooft

发明人： Cristian Presura ,  Carsten Heinks ,  Olaf Such ,  Gary N. Garcia Molina ,  Gert Hooft

IPC分类号： A61B5/1455

CPC分类号： A61B5/14551 ,  A61B5/721

摘要： The invention relates to a blood oximeter for measuring the oxygenation and at least one other parameter of flowing blood in living tissue. According to the invention, the blood oximeter comprises two lightsources (2, 3) emitting light of different wavelengths into tissue, and preferably a light detector (4) for detecting a transmitted and/or reflected part of the light emitted into the tissue, wherein at least one of the light sources is a laser with a laser cavity emitting a laser beam, the laser being adapted to allow a part of the laser beam which is scattered by the tissue to re-enter into the laser cavity, and wherein a laser beam sensor (7, 8) for measuring the light emitted from the laser is provided, the laser beam sensor (7, 8), thus, obtaining a signal which varies in accordance with the self-mixing interferometric effect between the original laser beam and the scattered laser beam. Accordingly, such a blood oximeter is provided that performs well at low perfusion and which further allows for reliable measurements

摘要翻译： 本发明涉及一种血氧计，用于测量活组织中血液的氧合和至少一种其它参数。 根据本发明，血液计包括将不同波长的光发射到组织中的两个光源（2,3），并且优选地包括用于检测发射到组织中的光的透射和/或反射部分的光检测器（4），其中 光源中的至少一个是具有发射激光束的激光腔的激光器，所述激光器适于允许被组织散射的激光束的一部分重新进入激光腔，并且其中激光器 提供了用于测量从激光发射的光的光束传感器（7,8），激光束传感器（7,8）获得根据原始激光束与原始激光束之间的自混合干涉效应而变化的信号 分散的激光束。 因此，提供了这样一种在低灌注下表现良好并且进一步允许可靠测量的血液计

公开(公告)号：US20100002238A1

公开(公告)日：2010-01-07

申请号：US12444706

申请日：2007-10-09

申请人： Cristian Presura ,  Gary Nelson Garcia Molina ,  Galileo June Destura

发明人： Cristian Presura ,  Gary Nelson Garcia Molina ,  Galileo June Destura

IPC分类号： G01B9/02

CPC分类号： G06F3/041 ,  G06F3/0421

摘要： A system and method for location determination by laser interference detection uses a wide beamwidth laser projection (301) across a planar area (300). A lens system (222) is used to provide the wide beamwidth projection, and a split-beam system (225) is used to correlate interference patterns to particular segments of the wide beamwidth projection. The reflected interference beams are detected on a detector array (240) that is configured to detect the undulations corresponding to objects within the wide beamwidth projection.

摘要翻译： 用于通过激光干涉检测进行位置确定的系统和方法在平面区域（300）上使用宽波束宽度激光投影（301）。 使用透镜系统（222）来提供宽的波束宽度投影，并且使用分束系统（225）将干涉图案与宽波束宽度投影的特定段相关联。 在被配置为检测对应于宽波束宽度投影内的物体的波动的检测器阵列（240）上检测反射的干涉光束。

公开(公告)号：US20080146952A1

公开(公告)日：2008-06-19

申请号：US11815451

申请日：2006-02-03

申请人： Cristian Presura ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Antonius Hermanus Maria Akkermans

发明人： Cristian Presura ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Antonius Hermanus Maria Akkermans

IPC分类号： A61B5/02

CPC分类号： G06K9/0012 ,  A61B5/02444

摘要： A method is proposed for investigation of or ascertaining pulse or heartbeat. The method first comprises directing illuminating radiation to illuminate a body part such as a finger. The illuminating radiation is of a wavelength or wavelength band substantially in the blue light region of the light spectrum. Then, an optical speckle pattern of the illuminated body part resulting from the illumination of the body part is obtained and imaged. The optical speckle pattern is representative of the heartbeat and by correlation of frames extracted from the speckle pattern, the pulse or beat extent of the body part may be ascertained.

摘要翻译： 提出了一种用于调查或确定脉搏或心跳的方法。 该方法首先包括引导照射辐射以照射诸如手指的身体部位。 照明辐射具有基本上在光谱的蓝光区域中的波长或波长带。 然后，获得由身体部位的照射产生的照明体部的光学散斑图案并成像。 光斑图案代表心跳和通过从斑点图案提取的帧的相关性，可以确定身体部位的脉搏或搏动程度。

公开(公告)号：US08185189B2

公开(公告)日：2012-05-22

申请号：US11721468

申请日：2005-12-15

申请人： Cristian Presura ,  Maarten Van Herpen

发明人： Cristian Presura ,  Maarten Van Herpen

IPC分类号： A61B8/00 ,  A61B6/00

CPC分类号： A61B5/1455 ,  A61B5/0059 ,  A61B5/0095 ,  A61B5/02007 ,  A61B5/489

摘要： A pulsed radiation beam is directed toward a body structure having a configuration or physical characteristic that changes over time, the radiation being pulsed at a pulse modulation frequency. A detector detects acoustic oscillations set up in the body resultant from the incident pulsed radiation and produces an output signal representative of one or more parameters of the acoustic oscillations. A control system controls operation of the radiation delivery and a processor to process the detector output signal. The pulse modulation frequency of the pulsed radiation is changed over a predetermined range of modulation frequencies and the processor determines the structure resonant frequency from the detector output.

摘要翻译： 脉冲辐射束指向具有随时间变化的配置或物理特性的体结构，辐射以脉冲调制频率脉冲。 检测器检测由入射脉冲辐射产生的身体中产生的声振荡并产生表示声振荡的一个或多个参数的输出信号。 控制系统控制辐射传送的操作和处理器来处理检测器输出信号。 脉冲辐射的脉冲调制频率在调制频率的预定范围内改变，并且处理器从检测器输出确定结构谐振频率。

公开(公告)号：US20080192229A1

公开(公告)日：2008-08-14

申请号：US11910475

申请日：2006-03-29

申请人： Alphons Antonius Maria Lambertus Bruekers ,  Cristian Presura ,  Antonius Hermanus Maria Akkermans ,  Thomas Andreas Maria Kevenaar ,  Minne Van Der Veen ,  Marijn Christian Damstra

发明人： Alphons Antonius Maria Lambertus Bruekers ,  Cristian Presura ,  Antonius Hermanus Maria Akkermans ,  Thomas Andreas Maria Kevenaar ,  Minne Van Der Veen ,  Marijn Christian Damstra

IPC分类号： G01P3/36

CPC分类号： G06F3/0421 ,  G01P3/366 ,  G01P13/02 ,  G01S17/50 ,  G01S17/87

摘要： A relative movement sensor for measuring movement of an object (15) and the sensor relative to each other, the sensor comprising a plurality of lasers (3,5) for generating respective measuring beams and illuminating the object (15) therewith, and a plurality of respective photodiodes (4,6) for measuring changes in operation of each laser cavity caused by reflected measuring beam radiation re-entering the respective laser cavity and the optical wave in the laser cavity. The plurality of lasers (3,5) are operated in a time-multiplexed manner such that only a subset (i.e. one or more) of the lasers is operated at any one time, the remaining lasers being idle. This reduces peak power dissipation and prevents erroneous interference caused by measuring beam radiation from one laser entering the cavity of another laser.

摘要翻译： 一种用于测量物体（15）和传感器相对于彼此的运动的相对运动传感器，所述传感器包括用于产生相应测量光束并且与其对照的物体（15）的多个激光器（3,5），以及多个 用于测量由反射的测量光束辐射重新进入相​​应的激光腔和激光腔中的光波引起的每个激光腔的操作变化的各个光电二极管（4,6）。 多个激光器（3,5）以时间复用的方式操作，使得只有一个激光器的子集（即一个或多个）在任何一个时间被操作，剩余的激光器是空闲的。 这降低了峰值功率消耗，并防止了通过测量来自一个激光器进入另一激光器的腔体的光束辐射引起的错误干扰。

公开(公告)号：US20080166029A1

公开(公告)日：2008-07-10

申请号：US11816297

申请日：2006-02-09

申请人： Cristian Presura

发明人： Cristian Presura

IPC分类号： G06K9/00

CPC分类号： G06K9/00033

摘要： Sweat ducts present on finger prints can be used in biometric identification or authentication systems as a differentiating or corroborating biometric feature. In addition, the activity of sweat ducts can be seen as a proof of liveness. By stimulating an object such as a finger by blowing air over the skin surface, it is possible to evoke sweat from the sweat ducts. The presence of these small droplets of sweat on the skin surface can be used to locate the position of sweat ducts, using either a spatial or temporal analysis of images of the skin surface. In addition, a temporal analysis can highlight sweat duct activity, which in turn can be used as a proof of liveness.

摘要翻译： 指纹上存在的汗管可用于生物识别或认证系统，作为区分或确认的生物特征。 此外，汗管的活动可以看作是活力的证明。 通过在皮肤表面上吹空气来刺激诸如手指的物体，可以从汗管引起汗液。 使用这些皮肤表面上的这些小滴汗液可以用于通过对皮肤表面的图像的空间或时间分析来定位汗管的位置。 此外，时间分析可以突出出汗管活动，反过来可以将其用作活力证明。

公开(公告)号：US07283236B2

公开(公告)日：2007-10-16

申请号：US10882683

申请日：2004-07-02

申请人： Cristian Presura ,  Jan Evert Van Der Werf

发明人： Cristian Presura ,  Jan Evert Van Der Werf

IPC分类号： G01B11/00 ,  G03B27/42 ,  G03B27/32 ,  H01L23/544 ,  H01L21/76 ,  G03F9/00 ,  G03C5/00

CPC分类号： G03F9/7076

摘要： A marker structure on a substrate includes line elements and trench elements, the line elements and trench elements each having a length in a first direction and being arranged in an alternating repetitive sequence in a second direction perpendicular to the first direction, the alternating repetitive sequence having a sequence length, the marker structure having at least one pitch value, the at least one pitch value being the sum of a line width of one line element and a trench width of one trench element. A width of the line elements varies over the sequence length of the marker structure between a minimum line width value and a maximum line width value, while a width of the trench elements likewise varies over the sequence length of the marker structure between a minimum trench width value and a maximum trench width value. A duty cycle of a pair of a line element and an adjacent trench element is substantially constant over the sequence length of the marker structure. Thus, the pitch value varies from a minimum pitch value to a maximum pitch value over the sequence length.

摘要翻译： 衬底上的标记结构包括线元件和沟槽元件，线元件和沟槽元件各自具有在第一方向上的长度并且在垂直于第一方向的第二方向上以交替的重复序列排列，所述交替重复序列具有 序列长度，所述标记结构具有至少一个间距值，所述至少一个间距值是一个线形元件的线宽和一个沟槽元件的沟槽宽度之和。 线元素的宽度在标记结构的序列长度之间在最小线宽度值和最大线宽度值之间变化，而沟槽元件的宽度同样在标记结构的序列长度之间变化，最小沟宽度 值和最大沟槽宽度值。 一对线元件和相邻沟槽元件的占空比在标记结构的序列长度上基本上是恒定的。 因此，音调值在序列长度上从最小音调值变化到最大音调值。