利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

51 条记录 (耗时 0.032 秒)

    3-amin3-arylpropan-1-ol compounds, their preparation and use
    11.
    发明授权
    3-amin3-arylpropan-1-ol compounds, their preparation and use 失效
    3-氨基-3-芳基丙-1-醇化合物，其制备和用途

    公开(公告)号：US06410790B1

    公开(公告)日：2002-06-25

    申请号：US09545371

    申请日：2000-04-07

    申请人： Bernd Sundermann ,  Hagen-Heinrich Hennies ,  Babette-Yvonne Koegel ,  Helmut Buschmann

    发明人： Bernd Sundermann ,  Hagen-Heinrich Hennies ,  Babette-Yvonne Koegel ,  Helmut Buschmann

    IPC分类号： C07C21100

    CPC分类号： C07D295/096 ,  C07C215/28 ,  C07C215/42 ,  C07C215/64 ,  C07C215/70 ,  C07C217/74 ,  C07C229/38 ,  C07C255/59 ,  C07C323/32 ,  C07C2601/14 ,  C07D307/52 ,  C07D317/58 ,  C07D333/20

    摘要： 3-amino-3-arylpropan-1-ol compounds of formula I: R1 and R2 independently denoting C1-6 alkyl, or together denoting a (CH2)2-6 ring optionally substituted by phenyl, R3 denoting C3-6 alkyl, C3-6 cycloalkyl, aryl optionally containing heteroatoms and optionally substituted by R6 to R8, or a substituted C1-3 alkylphenyl of formula XII:  R4 and R5 independently denoting C1-6 alkyl, C3-6 cycloalkyl, phenyl, benzyl, or phenethyl, or together forming a (CH2)3-6 or CH2CH2OCH2CH2 ring, R6 to R8 independently denoting H, F, Cl, Br, CHF2, CF3, OH, OCF3, OR14, NR15R16, SR14, phenyl, SO2CH3, SO2CF3, C1-6 alkyl, CN, COOR14, or CONR15R16, or together forming a OCH2O, OCH2CH2O, CH═CHO, CH═C(CH3)O or (CH2)4 ring, R14 denoting C1-6 alkyl, phenyl, benzyl, or phenethyl, R15 and R16 independently denoting H, C1-6 alkyl, phenyl, benzyl or phenethyl, and A denoting optionally substituted aryl optionally containing heteroatoms, or a diastereomer or enantiomer or pharmaceutically acceptable salt thereof, and their preparation and use in pharmaceutical compositions.

    摘要翻译： 式I的3-氨基-3-芳基丙-1-醇化合物：R 1和R 2独立地表示C 1-6烷基，或一起表示任选被苯基取代的（CH 2）2-6环，R 3表示C 3-6烷基，C 3 -6环烷基，任选含有杂原子并任选被R 6至R 8取代的芳基或式XII的取代的C 1-3烷基苯基：R 4和R 5独立地表示C 1-6烷基，C 3-6环烷基，苯基，苄基或苯乙基，或 一起形成（CH2）3-6或CH2CH2OCH2CH2环，R6至R8独立地表示H，F，Cl，Br，CHF2，CF3，OH，OCF3，OR14，NR15R16，SR14，苯基，SO2CH3，SO2CF3，C1-6烷基 ，CN，COOR 14或CONR 15 R 16，或一起形成OCH 2 O，OCH 2 CH 2 O，CH = CHO，CH = C（CH 3）O或（CH 2）4环，R 14表示C 1-6烷基，苯基，苄基或苯乙基，R 15和 R16独立地表示H，C 1-6烷基，苯基，苄基或苯乙基，A表示任选地含有杂原子的任选取代的芳基，或其非对映异构体或对映异构体或其药学上可接受的盐， 在药物组合物中的应用和用途。