公开(公告)号：US10258580B2

公开(公告)日：2019-04-16

申请号：US14128208

申请日：2012-06-29

申请人： Teresa Iuvone ,  Vincenzo Di Marzo ,  Geoffrey Guy ,  Stephen Wright ,  Colin Stott

发明人： Teresa Iuvone ,  Vincenzo Di Marzo ,  Geoffrey Guy ,  Stephen Wright ,  Colin Stott

IPC分类号： A61K31/05 ,  A61K31/352 ,  A61K31/192

摘要： The present invention relates to cannabinoids for use in the prevention or treatment of neurodegenerative diseases or disorders. Preferably the cannabinoids are cannabichromene (CBC) cannabidivarin (CBDV) and/or cannabidivarin acid (CBDVA). More preferably the neurodegenerative disease or disorder to be prevented or treated is Alzheimer's disease.

公开(公告)号：US08673368B2

公开(公告)日：2014-03-18

申请号：US12087847

申请日：2007-01-17

申请人： Geoffrey Guy ,  Bettina Platt

发明人： Geoffrey Guy ,  Bettina Platt

IPC分类号： A01N65/00

CPC分类号： A61K31/05 ,  A61K31/352 ,  A61K36/00 ,  A61K36/185 ,  A61P9/10 ,  A61P25/08 ,  A61P25/16 ,  A61P25/28 ,  A61P29/00 ,  A61P37/00 ,  A61K2300/00

摘要： The invention relates to the use of cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration. In particular, the invention relates to use of one or more cannabinoid-containing plant extracts in the prevention or treatment of neural degeneration, wherein the one or more cannabinoid-containing plant extracts comprise: i) a cannabinoid-containing fraction; and ii) a non-cannabinoid containing fraction.

摘要翻译： 本发明涉及含有大麻素的植物提取物在预防或治疗神经变性中的用途。 特别地，本发明涉及一种或多种含大麻素的植物提取物在预防或治疗神经变性中的用途，其中所述一种或多种含有大麻素的植物提取物包括：i）含大麻素的级分; 和ii）含有非大麻素的级分。

公开(公告)号：US20090306221A1

公开(公告)日：2009-12-10

申请号：US12227886

申请日：2007-05-31

申请人： Geoffrey Guy ,  Roger Pertwee ,  Adele Thomas

发明人： Geoffrey Guy ,  Roger Pertwee ,  Adele Thomas

IPC分类号： A61K31/05 ,  A61P3/04 ,  A61P25/00

CPC分类号： A61K31/05 ,  A61K31/352

摘要： The present invention relates to the use of one or more cannabinoids in the manufacture of medicaments for use in 0 the treatment of diseases and conditions benefiting from inverse agonism of the CB1 and/or the CB2 cannabinoid receptor. Preferably the cannabinoid is a cannabidiol (CBD) type compound or derivative thereof.

摘要翻译： 本发明涉及一种或多种大麻素在制备用于治疗受益于CB1和/或CB2大麻素受体的反向激动的疾病和病症的药物中的用途。 大麻素优选为大麻二醇（CBD）型化合物或其衍生物。

公开(公告)号：US20060261084A1

公开(公告)日：2006-11-23

申请号：US11493091

申请日：2006-07-26

申请人： Matthew Grey ,  Martin Riddiford ,  Geoffrey Guy ,  Rajiv Dave

发明人： Matthew Grey ,  Martin Riddiford ,  Geoffrey Guy ,  Rajiv Dave

IPC分类号： B67D5/08

CPC分类号： A61J7/0481 ,  A61J7/0445 ,  A61M15/00 ,  A61M15/008 ,  A61M15/0081 ,  A61M15/0083 ,  A61M15/009 ,  A61M2205/18 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/3569 ,  A61M2205/3576 ,  A61M2205/3584 ,  A61M2205/3592 ,  A61M2205/52 ,  A61M2205/6072 ,  A61M2205/8206 ,  A61M2205/8237

摘要： A dispensing system for controlled, especially remote controlled, dispensing of medicaments is disclosed. The system consists of a dispensing mechanism adapted to receive a sealed or resealable container of material to be dispensed and to validate that it is the correct material, and which includes a mechanical actuation mechanism which, when actuated, causes a measured dose of material to be dispensed from the material container. The mechanical actuation mechanism may be inhibited from operation by a locking mechanism which, when actuated, locks the device against the further dispensing of a dose of material until release in accordance with the desired dispensing programme, e.g. until a certain time period has elapsed, or until the programme permits dispensing to occur on some other basis. The dispensing system may be in two parts, a hand-held hand-actuated dispensing mechanism (1) and a base or docking station (2) into which the hand-held unit may be placed in order to release the locking mechanism. The docking or base station (2) may be triggered to cooperate with a remote overall control system, for example a remote computer, by placing the hand-held dispensing mechanism (1) in it.

公开(公告)号：US10004684B2

公开(公告)日：2018-06-26

申请号：US10468041

申请日：2002-02-14

申请人： Brian Whittle ,  Geoffrey Guy

发明人： Brian Whittle ,  Geoffrey Guy

IPC分类号： A61K31/353 ,  A61K9/00 ,  A61K9/107 ,  A61K9/12 ,  A61K9/24

CPC分类号： A61K9/0031 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/0073 ,  A61K9/107 ,  A61K9/1075 ,  A61K9/122 ,  A61K9/2018 ,  A61K9/2063 ,  A61K9/209 ,  A61K9/4858 ,  A61K9/7007 ,  A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  A61K47/14 ,  A61K2300/00

摘要： The invention relates to pharmaceutical formulations for use in the administration of lipophilic medicaments via mucosal surfaces. In particular the invention provides pharmaceutical formulations for use in administration of a lipophilic medicament via a mucosal surface which upon hydration form an emulsion containing the lipophilic medicament which is capable of adhering to a mucosal surface and allowing controlled release of the medicament. The invention further provides pharmaceutical formulations which contain, as active ingredients, specific combinations of cannabinoids in pre-defined ratios.

公开(公告)号：US08771760B2

公开(公告)日：2014-07-08

申请号：US13093911

申请日：2011-04-26

申请人： Geoffrey Guy ,  Philip Robson

发明人： Geoffrey Guy ,  Philip Robson

IPC分类号： A61K36/00 ,  A61K31/35 ,  A61K31/07

CPC分类号： A61K31/05 ,  A61K31/353 ,  A61K2300/00

摘要： The present invention relates to treatment of cancer related pain and constipation. Preferably the subject in need is administered a combination of the cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). More preferably the cannabinoids are in a predefined ratio by weight of approximately 1:1 of CBD to THC.

摘要翻译： 本发明涉及治疗癌症相关的疼痛和便秘。 优选地，给予大麻素大麻二酚（CBD）和δ-9-四氢大麻酚（THC）的组合。 更优选地，大麻素以CBD的重量约1:1的预定比例与THC。

公开(公告)号：US07622140B2

公开(公告)日：2009-11-24

申请号：US10476718

申请日：2002-05-07

申请人： Brian Whittle ,  Geoffrey Guy ,  David Downs ,  David Pate

发明人： Brian Whittle ,  Geoffrey Guy ,  David Downs ,  David Pate

IPC分类号： A61K36/00

CPC分类号： A61K31/05 ,  A61K31/352 ,  A61K36/185 ,  B01D11/0242 ,  B01D11/0273 ,  B01D11/028 ,  B01D11/0288 ,  B01D2011/007

摘要： Processes for preparing extracts of natural products such as plant material, and for preparing purified extracts from crude extracts of natural products, by extraction with hot gas. Apparatus suitable for use in preparing extracts of natural products are also described.

摘要翻译： 用于制备天然产物如植物材料的提取物的方法，以及通过用热气提取从天然产物的粗提物制备纯化提取物的方法。 还描述了适用于制备天然产物提取物的装置。

公开(公告)号：US20080139667A1

公开(公告)日：2008-06-12

申请号：US11628814

申请日：2005-06-07

申请人： Philip Robson ,  Geoffrey Guy

发明人： Philip Robson ,  Geoffrey Guy

IPC分类号： A61K31/05 ,  A61P19/02

CPC分类号： A61K31/352 ,  A61K9/0073 ,  A61K31/047 ,  A61K31/05 ,  A61K36/185 ,  A61K47/10 ,  A61K2236/15 ,  A61K2236/39 ,  A61K2236/51 ,  A61K2236/55 ,  A61K2300/00

摘要： The invention relates to the use of a combination of cannabinoids for the treatment of pain, inflammation and/or disease modification in arthritis. Preferably the cannabinoids are selected from cannabidiol (CBD) or cannabidivarin (CBDV) and delta-9-tetrahydrocannabinol (THC) or tetrahydrocannabinovarin (THCV). More preferably the cannabinoids are in a predefined ratio by weight of less than or equal to 19:1 of CBD or CBDV to THC or THCV.

摘要翻译： 本发明涉及大麻素组合用于治疗关节炎中的疼痛，炎症和/或疾病改变的用途。 优选地，大麻素选自大麻二醇（CBD）或大麻素（CBDV）和δ-9-四氢大麻酚（THC）或四氢大麻素（THCV）。 更优选地，大麻素以CBD或CBDV与THC或THCV的重量比小于或等于19:1的预定比例。

公开(公告)号：US20060247304A1

公开(公告)日：2006-11-02

申请号：US11115983

申请日：2005-04-27

申请人： Geoffrey Guy ,  Philip Robson

发明人： Geoffrey Guy ,  Philip Robson

IPC分类号： A61K31/353

CPC分类号： A61K31/05 ,  A61K31/353 ,  A61K2300/00

摘要： The present invention relates to treatment of cancer related pain and constipation. Preferably the subject in need is administered a combination of the cannabinoids cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC). More preferably the cannabinoids are in a predefined ratio by weight of approximately 1:1 of CBD to THC.

摘要翻译： 本发明涉及治疗癌症相关的疼痛和便秘。 优选地，给予大麻素大麻二酚（CBD）和δ-9-四氢大麻酚（THC）的组合。 更优选地，大麻素以CBD的重量约1:1的预定比例与THC。

公开(公告)号：US20120245224A1

公开(公告)日：2012-09-27

申请号：US13491077

申请日：2012-06-07

申请人： Geoffrey Guy ,  Barbara Costa

发明人： Geoffrey Guy ,  Barbara Costa

IPC分类号： A61K31/352 ,  A61P25/00

CPC分类号： A61K31/05 ,  A61K31/352 ,  A61K2300/00

摘要： The present invention relates to the use of cannabidiol (CBD) type compounds or derivative thereof and tetrahydrocannabinol (THC) type compounds or derivative thereof in the manufacture of a medicament for the treatment of neuropathic pain. Preferably, the ratio of the CBD type compounds or derivative thereof and THC type compounds or derivative thereof is between 18:1 and 30:1. More preferably the CBD type compounds or derivative thereof and THC type compounds or derivative thereof are in the form of plant extracts.

摘要翻译： 本发明涉及大麻二醇（CBD）型化合物或其衍生物和四氢大麻酚（THC）型化合物或其衍生物在制备用于治疗神经性疼痛的药物中的用途。 优选地，CBD型化合物或其衍生物和THC型化合物或其衍生物的比例为18:1至30:1。 更优选CBD型化合物或其衍生物和THC型化合物或其衍生物是植物提取物的形式。