公开(公告)号：US06316013B1

公开(公告)日：2001-11-13

申请号：US09671446

申请日：2000-09-27

申请人： Susan Carol Paul ,  Frank Jerrel Akin ,  Robert Cosmo Di Luccio ,  Dennis Stein Everhart ,  Elizabeth Deibler Gadsby ,  Pamela Jean Mayberry ,  Audra Stefanik Wright ,  Ali Yahiaoui ,  Michael John Faulks ,  Duane Gerard Krzysik ,  Karen Marie Menard ,  David Charles Musil ,  Frank Andrew Rosch, III ,  Gordon Allen Shaw ,  David John Tyrrell ,  Diane Michele Underhill ,  Jeffrey Michael Hockersmith ,  Gunilla Elsa Gillberg-LaForce ,  Wade Bolton May

发明人： Susan Carol Paul ,  Frank Jerrel Akin ,  Robert Cosmo Di Luccio ,  Dennis Stein Everhart ,  Elizabeth Deibler Gadsby ,  Pamela Jean Mayberry ,  Audra Stefanik Wright ,  Ali Yahiaoui ,  Michael John Faulks ,  Duane Gerard Krzysik ,  Karen Marie Menard ,  David Charles Musil ,  Frank Andrew Rosch, III ,  Gordon Allen Shaw ,  David John Tyrrell ,  Diane Michele Underhill ,  Jeffrey Michael Hockersmith ,  Gunilla Elsa Gillberg-LaForce ,  Wade Bolton May

IPC分类号： A01N2534

CPC分类号： A61L15/34 ,  A61F13/15203 ,  A61L15/46 ,  A61L2300/102 ,  A61L2300/252 ,  A61L2300/412

摘要： An absorbent article includes a vapor permeable backsheet, a liquid permeable topsheet positioned in facing relation with the backsheet; and an absorbent body located between the backsheet and the topsheet. The absorbent body may include multiple zones of high air permeability. The absorbent article may also include a ventilation layer between the absorbent body and the backsheet and a surge management layer between the absorbent body and the topsheet. The article exhibits improved air exchange within the article during use. As a result, the article maintains the temperature and exhibits substantially reduced levels of hydration of the wearer's skin when in use which renders the skin less susceptible to the viability of microorganisms. The absorbent article may further include lotion formulations and/or treatment compositions thereon for maintaining or improving skin health.

公开(公告)号：US06217890B1

公开(公告)日：2001-04-17

申请号：US09379431

申请日：1999-08-23

申请人： Susan Carol Paul ,  Frank Jerrel Akin ,  Robert Cosmo Di Luccio ,  Dennis Stein Everhart ,  Elizabeth Deibler Gadsby ,  Pamela Jean Mayberry ,  Audra Stefanik Wright ,  Ali Yahiaoui ,  Michael John Faulks ,  Duane Gerard Krzysik ,  Karen Marie Menard ,  David Charles Musil ,  Frank Andrew Rosch, III ,  Gordon Allen Shaw ,  David John Tyrrell ,  Diane Michele Underhill ,  Jeffrey Michael Hockersmith ,  Gunilla Elsa Gillberg-LaForce ,  Wade Bolton May

发明人： Susan Carol Paul ,  Frank Jerrel Akin ,  Robert Cosmo Di Luccio ,  Dennis Stein Everhart ,  Elizabeth Deibler Gadsby ,  Pamela Jean Mayberry ,  Audra Stefanik Wright ,  Ali Yahiaoui ,  Michael John Faulks ,  Duane Gerard Krzysik ,  Karen Marie Menard ,  David Charles Musil ,  Frank Andrew Rosch, III ,  Gordon Allen Shaw ,  David John Tyrrell ,  Diane Michele Underhill ,  Jeffrey Michael Hockersmith ,  Gunilla Elsa Gillberg-LaForce ,  Wade Bolton May

IPC分类号： A61N2534

CPC分类号： A61L15/48 ,  A61F13/15203 ,  A61F2013/15284 ,  A61F2013/53795 ,  A61L15/18 ,  A61L15/32 ,  A61L15/34 ,  A61L15/46 ,  A61L2300/22 ,  A61L2300/412

摘要： An absorbent article includes a vapor permeable backsheet, a liquid permeable topsheet positioned in facing relation with the backsheet; and an absorbent body located between the backsheet and the topsheet. The absorbent body may include multiple zones of high air permeability. The absorbent article may also include a ventilation layer between the absorbent body and the backsheet and a surge management layer between the absorbent body and the topsheet. The article exhibits improved air exchange within the article during use. As a result, the article maintains the temperature and exhibits substantially reduced levels of hydration of the wearer's skin when in use which renders the skin less susceptible to the viability of microorganisms. The absorbent article may further include lotion formulations and/or treatment compositions thereon for maintaining or improving skin health.

公开(公告)号：US06749860B2

公开(公告)日：2004-06-15

申请号：US09747382

申请日：2000-12-22

申请人： David John Tyrrell ,  Chantel Spring Buhrow ,  Beth Anne Lange ,  Duane Gerard Krzysik ,  Earl David Brock ,  James Louis Cahall ,  Samuel Qcheng Lin ,  Ronni Lynn Weinkauf ,  Uma Santhanan

发明人： David John Tyrrell ,  Chantel Spring Buhrow ,  Beth Anne Lange ,  Duane Gerard Krzysik ,  Earl David Brock ,  James Louis Cahall ,  Samuel Qcheng Lin ,  Ronni Lynn Weinkauf ,  Uma Santhanan

IPC分类号： A01N2534

CPC分类号： A61F13/511 ,  A61F13/8405 ,  A61F2013/51117 ,  A61L15/18 ,  A61L15/20 ,  A61L15/34 ,  A61L15/40 ,  A61L15/46 ,  A61L2300/22 ,  A61L2300/222 ,  A61L2300/30 ,  Y10T442/2525

摘要： The present invention relates to absorbent articles including non-aqueous compositions for protecting the barrier function of the skin. The compositions can be applied to the bodyfacing surfaces of absorbent articles so that the compositions come into contact with the skin. The compositions of the invention have improved stability on the bodyfacing surfaces after processing. The compositions of the invention provide several benefits including prevention and alleviation of skin irritations associated with the use of absorbent articles. The compositions can include emollients, viscosity enhancers and extracted botanical actives.

摘要翻译： 本发明涉及包含用于保护皮肤屏障功能的非水性组合物的吸收制品。 组合物可以应用于吸收制品的身体表面，使得组合物与皮肤接触。 本发明的组合物在加工后具有改善的身体表面的稳定性。 本发明的组合物提供若干益处，包括预防和缓解与使用吸收制品相关的皮肤刺激。 组合物可以包括润肤剂，粘度增强剂和提取的植物活性物质。

公开(公告)号：US06497893B1

公开(公告)日：2002-12-24

申请号：US09343861

申请日：1999-06-30

申请人： Dennis Stein Everhart ,  Robert Cosmo Di Luccio ,  Ali Yahiaoui ,  Wade Bolton May ,  David John Tyrrell ,  Elizabeth Deibler Gadsby ,  Gunilla Elsa Gillberg-LaForce

发明人： Dennis Stein Everhart ,  Robert Cosmo Di Luccio ,  Ali Yahiaoui ,  Wade Bolton May ,  David John Tyrrell ,  Elizabeth Deibler Gadsby ,  Gunilla Elsa Gillberg-LaForce

IPC分类号： A61N2534

CPC分类号： A61Q19/00 ,  A61K8/0208 ,  A61K8/64 ,  A61L15/18 ,  A61L15/32 ,  A61L15/48 ,  Y10S514/865

摘要： The present invention relates to a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a silk protein on skin by an aqueous emulsion mediated dissolution of protein from a substrate with subsequent transfer and deposition onto the skin. Coatings of silk protein on skin resist removal, thereby providing a protective barrier against chemically- and biochemically-induced skin damage. The treatment composition also provides a vehicle for administering an effective dose of an active agent to the skin surface.

摘要翻译： 本发明涉及一种局部递送系统，其有效地通过水性乳剂介导蛋白质从底物的溶解而沉积薄皮层，牢固且基本上连续的丝蛋白涂层，随后转移和沉积到皮肤上。 皮肤上的丝蛋白涂层可以抵抗去除，从而为化学和生物化学诱导的皮肤损伤提供保护性屏障。 治疗组合物还提供了向皮肤表面施用有效剂量的活性剂的载体。

公开(公告)号：US06503524B1

公开(公告)日：2003-01-07

申请号：US09596162

申请日：2000-06-16

申请人： David John Tyrrell ,  Robert Cosmo Di Luccio ,  Ali Yahiaoui ,  Dennis Stein Everhart ,  Wade Bolton May

发明人： David John Tyrrell ,  Robert Cosmo Di Luccio ,  Ali Yahiaoui ,  Dennis Stein Everhart ,  Wade Bolton May

IPC分类号： A01N2534

CPC分类号： A61L15/48 ,  A61F13/8405 ,  A61L15/32

摘要： The present invention relates to a combination for surface treatment of a substrate, e.g. a nonwoven web, used in personal care product applications. The surface treatment combination not only provides adequate fluid handling properties, but also provides a topical delivery system effective in depositing a thin, tenacious and substantially continuous coating of a skin health benefit agent on skin by an aqueous emulsion mediated dissolution of the agent from a substrate with subsequent transfer and deposition onto the skin. Coatings of the skin health benefit agent on the skin resist removal, thereby preventing damage to the natural skin barrier and providing a protective barrier against chemically- and biochemically-induced skin damage.

摘要翻译： 本发明涉及一种用于表面处理基材的组合，例如， 非织造网，用于个人护理产品应用。 表面处理组合不仅提供足够的流体处理性能，而且还提供了一种局部递送系统，其有效地通过水性乳液介导的药剂从底物的溶解沉积皮肤健康有益剂在皮肤上的薄而牢固且基本上连续的涂层 随后转移和沉积到皮肤上。 皮肤上的皮肤健康有益剂对皮肤的涂层抵抗去除，从而防止对天然皮肤屏障的损害，并提供防止化学和生化诱导的皮肤损伤的保护屏障。

公开(公告)号：US08552251B2

公开(公告)日：2013-10-08

申请号：US12856120

申请日：2010-10-08

申请人： Peiguang Zhou ,  David John Tyrrell ,  Andrew M. Long ,  Alphonse C. DeMarco ,  Dave Allen Soerens ,  Rebecca Ann Vongsa

发明人： Peiguang Zhou ,  David John Tyrrell ,  Andrew M. Long ,  Alphonse C. DeMarco ,  Dave Allen Soerens ,  Rebecca Ann Vongsa

IPC分类号： A61F13/15 ,  A61F13/20

CPC分类号： A61L15/44 ,  A61F13/8405 ,  A61L15/46

摘要： A laminate having health-benefit agents therein is made by particle stabilization within the lamination process. By changing the substrate type (tissue, nonwoven, film) and/or the physical composition and/or attributes of the laminate layers, the release of the health-benefit agents can be controlled. The laminate, sometimes referred to as a liner, may be used in personal absorbent articles such as diapers, feminine pads, bandages, bed pads, and the like.

摘要翻译： 其中具有健康益处的层压板通过层压过程中的颗粒稳定化而制成。 通过改变层压层的基底类型（组织，非织造材料，薄膜）和/或物理组成和/或属性，可以控制健康益处的释放。 有时称为衬垫的层压体可以用于个人吸收制品，例如尿布，女性衬垫，绷带，床垫等。

公开(公告)号：US20120089067A1

公开(公告)日：2012-04-12

申请号：US12856120

申请日：2010-10-08

申请人： Peiguang Zhou ,  David John Tyrrell ,  Andrew M. Long ,  Alphonse C. DeMarco ,  Dave Allen Soerens ,  Rebecca Ann Vongsa

发明人： Peiguang Zhou ,  David John Tyrrell ,  Andrew M. Long ,  Alphonse C. DeMarco ,  Dave Allen Soerens ,  Rebecca Ann Vongsa

IPC分类号： A61L15/44 ,  A61F13/00 ,  A61F13/53 ,  A61L15/46

CPC分类号： A61L15/44 ,  A61F13/8405 ,  A61L15/46

摘要： A laminate having health-benefit agents therein is made by particle stabilization within the lamination process. By changing the substrate type (tissue, nonwoven, film) and/or the physical composition and/or attributes of the laminate layers, the release of the health-benefit agents can be controlled. The laminate, sometimes referred to as a liner, may be used in personal absorbent articles such as diapers, feminine pads, bandages, bed pads, and the like.

摘要翻译： 其中具有健康益处的层压板通过层压过程中的颗粒稳定化而制成。 通过改变层压层的基底类型（组织，非织造材料，薄膜）和/或物理组成和/或属性，可以控制健康益处的释放。 有时称为衬垫的层压体可以用于个人吸收制品，例如尿布，女性衬垫，绷带，床垫等。

公开(公告)号：US06899700B2

公开(公告)日：2005-05-31

申请号：US10027269

申请日：2001-12-21

申请人： Steven Craig Gehling ,  Charles Christopher Keely ,  Jeffrey Dean Lindsay ,  Kimberly Marie Geiser ,  David William Koenig ,  Bernard Joseph Minerath ,  Barbara Jo Dvoracek ,  David John Tyrrell ,  Duane Gerard Krzysik

发明人： Steven Craig Gehling ,  Charles Christopher Keely ,  Jeffrey Dean Lindsay ,  Kimberly Marie Geiser ,  David William Koenig ,  Bernard Joseph Minerath ,  Barbara Jo Dvoracek ,  David John Tyrrell ,  Duane Gerard Krzysik

IPC分类号： A61F13/472 ,  A61F13/15 ,  A61F13/20 ,  A61F13/53 ,  A61K9/00 ,  A61K9/06 ,  A61K9/08 ,  A61K9/20 ,  A61K9/48 ,  A61K31/121 ,  A61K31/137 ,  A61K31/165 ,  A61K31/167 ,  A61K31/18 ,  A61K31/192 ,  A61K31/196 ,  A61K31/201 ,  A61K31/21 ,  A61K31/245 ,  A61K31/277 ,  A61K31/34 ,  A61K31/365 ,  A61K31/40 ,  A61K31/405 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4152 ,  A61K31/439 ,  A61K31/4422 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/496 ,  A61K31/5415 ,  A61K31/554 ,  A61K31/56 ,  A61K31/616 ,  A61K33/06 ,  A61K36/18 ,  A61K36/23 ,  A61K36/28 ,  A61K36/48 ,  A61K36/53 ,  A61K36/73 ,  A61K36/81 ,  A61K36/896 ,  A61K45/00 ,  A61L15/40 ,  A61L15/44 ,  A61P5/24 ,  A61P15/00 ,  A61M31/00

CPC分类号： A61F13/8405 ,  A61F13/2051 ,  A61F13/2085 ,  A61K9/0036 ,  A61L15/40 ,  A61L15/44 ,  A61L2300/30 ,  A61L2300/40 ,  A61L2300/402 ,  A61L2300/41 ,  A61L2300/432 ,  A61L2300/602 ,  Y10S604/904

摘要： A tampon adapted to deliver a therapeutic agent includes a body having a proximal end and a distal end. The body includes an absorbency zone adjacent the distal end, wherein the absorbency zone includes absorbent material; an application zone adjacent the proximal end and spaced apart from the distal end; and a therapeutic agent positioned substantially within the application zone. A method produces a device for delivering a therapeutic agent. The method includes manufacturing a tampon having a body with a distal end, a proximal end, an absorbency zone adjacent the distal end, and an application zone adjacent the proximal end; and locating a therapeutic agent substantially within the application zone.

摘要翻译： 适于递送治疗剂的棉塞包括具有近端和远端的本体。 身体包括邻近远端的吸收区，其中吸收区包括吸收材料; 邻近近端并与远端间隔开的应用区域; 以及基本上位于施用区域内的治疗剂。 一种方法产生用于递送治疗剂的装置。 该方法包括制造具有主体的卫生棉条，其具有远端，近端，邻近远端的吸收区域和邻近近端的应用区域; 以及将治疗剂基本上定位在所述应用区域内。

公开(公告)号：US07771735B2

公开(公告)日：2010-08-10

申请号：US10406957

申请日：2003-04-03

申请人： Barbara Jo Dvoracek ,  David John Tyrrell

发明人： Barbara Jo Dvoracek ,  David John Tyrrell

IPC分类号： A01N25/00 ,  A61K9/70

CPC分类号： A61L15/46 ,  A61F13/51113 ,  A61F13/8405 ,  A61L15/18 ,  A61L15/20 ,  A61L15/34 ,  A61L15/40 ,  A61L2300/222 ,  A61L2300/30 ,  A61L2300/434

摘要： The present invention relates to compositions and absorbent articles including compositions for protecting the skin barrier. The compositions can be applied to the bodyfacing surfaces of absorbent articles so that the compositions come into contact with the skin. The compositions of the invention provide several benefits including prevention and alleviation of skin irritations associated with the use of absorbent articles. The compositions can include hydrophilic and non-aqueous components as well as extracted botanical actives.

摘要翻译： 本发明涉及包含用于保护皮肤屏障的组合物的组合物和吸收制品。 组合物可以应用于吸收制品的身体表面，使得组合物与皮肤接触。 本发明的组合物提供若干益处，包括预防和缓解与使用吸收制品相关的皮肤刺激。 组合物可以包括亲水和非水性组分以及提取的植物活性物质。

公开(公告)号：US07041787B2

公开(公告)日：2006-05-09

申请号：US09753139

申请日：2000-12-29

申请人： Stephen Quirk ,  David John Tyrrell

发明人： Stephen Quirk ,  David John Tyrrell

IPC分类号： A61K38/00 ,  A61K38/04 ,  C12N15/09

CPC分类号： C07K7/06 ,  A61K47/64 ,  C07K7/08

摘要： The present invention relates to MMP regulators that comprise new synthetic peptides, that comprise amino acid sequences structurally similar to those of MMP binding region of TIMPs, coupled to zinc chelators. The invention also relates to methods for making these MMP regulators and their use for the treatment of chronic and acute wounds and for the treatment of angiogenesis-associated diseases.