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公开(公告)号：US08222424B2
公开(公告)日：2012-07-17
申请号：US12933988
申请日：2009-03-23
申请人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
发明人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
IPC分类号： C07D231/54 , A61K31/416
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此 可以用于治疗以MMP-2，/或MMP-8和/或MMP-9，和/或MMP-12和/或MMP-13异常活性为特征的疾病或疾病。 因此，式（I）化合物可用于治疗由MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP- 13。 最后，本发明还提供药物组合物。
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12.发明申请公开(公告)号：US20110112076A1
公开(公告)日：2011-05-12
申请号：US13003406
申请日：2009-07-13
IPC分类号： C07C259/06 , C07D211/60 , C07D309/06 , C07D277/06 , C07D211/78 , C07D213/56 , C07D223/06 , C07D401/12 , C07D207/48 , C07D215/36 , C07D295/145 , C07D209/52 , C07D279/12 , C07D221/22 , C07D413/12 , C07D405/12 , C07D413/14 , C07D277/80 , A61K31/165 , A61K31/445 , A61K31/351 , A61K31/426 , A61K31/44 , A61K31/55 , A61K31/4709 , A61K31/40 , A61K31/47 , A61K31/5375 , A61K31/403 , A61K31/54 , A61K31/439 , A61K31/536 , A61K31/4433 , A61K31/5377 , A61K31/428 , A61P11/06 , A61P11/02 , A61P11/08 , A61P19/02 , A61P9/10 , A61P35/00 , A61P35/04 , A61P1/02 , A61P9/04 , A61P9/00 , A61P43/00
CPC分类号： C07C311/29 , A61K31/18 , C07C311/19 , C07C311/42 , C07C311/46 , C07C323/60 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07D207/48 , C07D211/60 , C07D211/92 , C07D211/96 , C07D213/42 , C07D213/74 , C07D213/89 , C07D215/36 , C07D223/06 , C07D277/06 , C07D277/80 , C07D279/12 , C07D295/13 , C07D309/06 , C07D401/12 , C07D405/12 , C07D413/12 , C07D453/06 , C07D471/08 , C07D487/08
摘要： The present invention provides a compound of formula (I) said compound is inhibitor of MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-12 and/or MMP-13. Finally, the present invention also provides pharmaceutical composition that include the compound of formula (I).
摘要翻译： 本发明提供式（I）化合物，所述化合物是MMP-12和/或MMP-13的抑制剂，因此可用于治疗以MMP-12异常活性为特征的疾病或疾病和/或 MMP-13。 因此，式（I）化合物可用于治疗由MMP-12和/或MMP-13介导的病症或疾病。 最后，本发明还提供包含式（I）化合物的药物组合物。
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公开(公告)号：US20110014186A1
公开(公告)日：2011-01-20
申请号：US12933988
申请日：2009-03-23
申请人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
发明人： Claus Ehrhardt , Leslie Wighton McQuire , Pascal Rigollier , Olivier Rogel , Michael Shultz , Ruben Alberto Tommasi
IPC分类号： A61K31/18 , C07C311/29 , C07D213/40 , C07D295/112 , C07D223/04 , A61K31/4402 , A61K31/402 , A61K31/4453 , A61K31/495 , A61K31/40 , A61K31/381 , A61K31/55 , A61P11/06 , A61P11/00 , A61P19/02 , A61P9/10 , A61P35/00 , A61P35/04 , A61P25/28 , A61K31/41 , A61K31/4178 , A61K31/4174 , A61K31/496 , A61K31/403 , A61K31/437 , A61K39/00 , A61K39/395
CPC分类号： C07D333/22 , A61K31/18 , A61K31/381 , A61K31/402 , A61K31/416 , A61K31/437 , A61K31/4402 , A61K31/4409 , A61K31/451 , A61K31/495 , A61K31/5375 , A61K31/55 , A61K45/06 , C07C311/16 , C07C311/29 , C07C311/39 , C07C311/46 , C07C317/24 , C07C323/67 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/20 , C07D207/30 , C07D207/333 , C07D209/08 , C07D209/10 , C07D209/12 , C07D209/14 , C07D209/80 , C07D209/82 , C07D211/06 , C07D211/14 , C07D211/24 , C07D213/40 , C07D213/50 , C07D213/61 , C07D221/16 , C07D223/04 , C07D231/56 , C07D235/06 , C07D235/08 , C07D241/04 , C07D265/30 , C07D295/112 , C07D295/116 , C07D295/192 , C07D333/18 , C07D401/04 , C07D403/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D487/04
摘要： The present invention provides a compound of formula (I): said compound is inhibitor of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13, and thus can be employed for the treatment of a disorder or disease characterized by abnormal activity of MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12 and/or MMP-13. Accordingly, the compound of formula (I) can be used in treatment of disorders or diseases mediated by MMP-2, and/or MMP-8, and/or MMP-9, and/or MMP-12, and/or MMP-13. Finally, the present invention also provides a pharmaceutical composition.
摘要翻译： 本发明提供式（I）化合物：所述化合物是MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP-13的抑制剂，因此 可以用于治疗以MMP-2，/或MMP-8和/或MMP-9，和/或MMP-12和/或MMP-13异常活性为特征的疾病或疾病。 因此，式（I）化合物可用于治疗由MMP-2和/或MMP-8和/或MMP-9和/或MMP-12和/或MMP- 13。 最后，本发明还提供药物组合物。
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