Methods for the treatment and amelioration of atopic dermatitis
    14.
    发明授权
    Methods for the treatment and amelioration of atopic dermatitis 失效
    治疗和改善特应性皮炎的方法

    公开(公告)号:US07998945B2

    公开(公告)日:2011-08-16

    申请号:US12158615

    申请日:2006-12-20

    IPC分类号: A61K31/452 A61K31/661

    CPC分类号: A61K31/14

    摘要: The present invention relates to a method for the treatment and/or amelioration of atopic dermatitis, the method including the administration of a pharmaceutically active dose of a compound selected from miltefosine, edelfosine, perifosine and ilmofosine to a subject in need of such a treatment and/or amelioration.

    摘要翻译: 本发明涉及治疗和/或改善特应性皮炎的方法,所述方法包括向需要这种治疗的受试者施用药物活性剂量的选自米替福德,edelfosine,perifosine和ilmofosine的化合物,以及 /或改善。

    Means and Methods for the Treatment and Prevention of Allergic Diseases
    16.
    发明申请
    Means and Methods for the Treatment and Prevention of Allergic Diseases 失效
    治疗和预防过敏性疾病的手段和方法

    公开(公告)号:US20090018105A1

    公开(公告)日:2009-01-15

    申请号:US12158615

    申请日:2006-12-20

    IPC分类号: A61K31/685 A61P37/06

    CPC分类号: A61K31/14

    摘要: The present invention relates of the use of certain inner ionic (zwitter ionic) phospholipids, phosphonolipids and phosphate derivatives for the preparation of a pharmaceutical composition for the treatment, prevention and/or amelioration of an immunological disorder related to mast cell sensitization. Preferred in this context are edelfosine and miltefosine. In a particularly preferred embodiment, the present invention relates to the use of miltefosine for the preparation of a pharmaceutical composition for the treatment, prevention and/or amelioration of allergic diseases, in particular acute hyperallergic diseases, like asthma.

    摘要翻译: 本发明涉及某些内离子(两性离子)磷脂,磷脂酰脂和磷酸酯衍生物在制备用于治疗,预防和/或改善与肥大细胞增感相关的免疫学障碍的药物组合物中的用途。 在本文中优选的是edelfosine和miltefosine。 在特别优选的实施方案中,本发明涉及米替福星在制备用于治疗,预防和/或改善过敏性疾病,特别是急性高过敏性疾病如哮喘的药物组合物中的用途。

    Nerve Growth Factor Conjugates and Uses Thereof
    19.
    发明申请
    Nerve Growth Factor Conjugates and Uses Thereof 审中-公开
    神经生长因子共轭体及其用途

    公开(公告)号:US20110212122A1

    公开(公告)日:2011-09-01

    申请号:US12809261

    申请日:2008-12-22

    摘要: The present invention is in the fields of medicine, public health, immunology, molecular biology and virology. The invention provides composition comprising a virus-like particle (VLP) linked to at least one antigen, wherein said antigen is NGF antigen. The invention also provides a process for producing the composition. The compositions of this invention are useful in the production of vaccines, in particular, for the treatment of pain. Moreover, the compositions of the invention induce efficient immune responses, in particular antibody responses.

    摘要翻译: 本发明涉及医药,公共卫生,免疫学,分子生物学和病毒学领域。 本发明提供包含与至少一种抗原连接的病毒样颗粒(VLP)的组合物,其中所述抗原是NGF抗原。 本发明还提供了一种制备该组合物的方法。 本发明的组合物可用于疫苗的生产,特别是用于治疗疼痛。 此外,本发明的组合物诱导有效的免疫应答,特别是抗体应答。