公开(公告)号：US20210101936A1

公开(公告)日：2021-04-08

申请号：US16908204

申请日：2020-06-22

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Rosemary Dyane Rohde ,  Arundhati Nag ,  Samir Das ,  Aiko Umeda

IPC: C07K7/64 ,  A61K49/00 ,  C07K5/06 ,  C07K5/08 ,  A61K51/08 ,  C07K1/04 ,  C07K5/10 ,  C07K7/56 ,  C07K14/00 ,  G01N33/573 ,  G01N33/68

Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.

公开(公告)号：US10928389B2

公开(公告)日：2021-02-23

申请号：US15359464

申请日：2016-11-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Rong Fan ,  Habib Ahmad ,  James R. Heath

IPC: G01N33/543 ,  B01L3/00 ,  B01J19/00 ,  G01N33/58

Abstract: Arrays and substrates comprising a material, in particular capture agents and/or detectable targets, attached to the substrates along substantially parallel lines forming a barcoded pattern and related methods and systems.

公开(公告)号：US10598671B2

公开(公告)日：2020-03-24

申请号：US15211759

申请日：2016-07-15

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： James R. Heath ,  Heather Agnew ,  Blake Farrow ,  David Bunck ,  Jingxin Liang ,  Arundhati Nag ,  Samir Das ,  Bert Tsunyin Lai ,  Suresh Mark Pitram

IPC: G01N33/68 ,  C07K7/64 ,  C07K14/54 ,  C07K7/06

Abstract: The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.

公开(公告)号：US10597425B2

公开(公告)日：2020-03-24

申请号：US14484610

申请日：2014-09-12

Applicant: California Institute of Technology

Inventor： Jessica A. Pfeilsticker ,  Aiko Umeda ,  James R. Heath

IPC: C07K9/00 ,  C07K7/08 ,  G01N33/569

Abstract: The present application provides stable peptide-based anti-gp41 antibody capture agents and methods of use as detection and diagnosis agents. The application further provides methods of manufacturing anti-gp41 antibody capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20180072772A1

公开(公告)日：2018-03-15

申请号：US15680171

申请日：2017-08-17

Applicant: California Institute of Technology

Inventor： Kaycie Deyle ,  Blake Farrow ,  James R. Heath

IPC: C07K7/06 ,  C12N9/12 ,  G01N33/574 ,  C07K7/00 ,  G01N33/573

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K7/00 ,  C07K14/001 ,  C12N9/1205 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/912

Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US09913875B2

公开(公告)日：2018-03-13

申请号：US15072039

申请日：2016-03-16

Applicant: California Institute of Technology ,  Indi Molecular, Inc.

Inventor： Blake Farrow ,  James R. Heath ,  Heather Dawn Agnew

IPC: A61K38/48 ,  A61K38/55 ,  C07K14/81 ,  A61K38/00 ,  C07B59/00 ,  A61K47/48 ,  A61K38/12 ,  A61K38/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07K7/06 ,  G01N33/531 ,  G06F19/12

CPC classification number: A61K38/005 ,  A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07B2200/05 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  C07K2319/01 ,  C07K2319/70 ,  G01N33/531 ,  G01N2333/33 ,  G06F19/12 ,  Y02A50/469

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

公开(公告)号：US20160331800A1

公开(公告)日：2016-11-17

申请号：US15072039

申请日：2016-03-16

Applicant: California Institute of Technology

Inventor： Blake Farrow ,  James R. Heath

IPC: A61K38/00 ,  A61K47/48 ,  A61K38/12 ,  C07K7/06 ,  C07K7/52 ,  C07K5/083 ,  A61K38/08 ,  C07B59/00 ,  A61K38/06

CPC classification number: A61K38/005 ,  A61K38/00 ,  A61K38/06 ,  A61K38/08 ,  A61K38/12 ,  A61K47/60 ,  C07B59/008 ,  C07B2200/05 ,  C07K5/0808 ,  C07K7/06 ,  C07K7/08 ,  C07K7/52 ,  C07K2319/01 ,  C07K2319/70 ,  G01N33/531 ,  G01N2333/33 ,  G06F19/12 ,  Y02A50/469

Abstract: The present application provides stable peptide-based Botulinum neurotoxin (BoNT) serotype A capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing BoNT serotype A capture agents using iterative on-bead in situ click chemistry.

Abstract translation: 本申请提供了稳定的基于肽的肉毒杆菌神经毒素（BoNT）血清型A捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代珠粒原位点击化学制备BoNT血清型A捕获剂的方法。

公开(公告)号：US20160264627A1

公开(公告)日：2016-09-15

申请号：US15068528

申请日：2016-03-11

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Ryan K. Henning ,  Ashwin N. Ram ,  Samir Das ,  Arundhati Nag ,  James R. Heath

IPC: C07K7/64 ,  G01N33/68

CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K7/06 ,  C07K14/82 ,  G01N33/5748 ,  G01N2333/82 ,  G01N2333/914 ,  G01N2500/04

Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.

Abstract translation: 其中Z1和Z2分别为L-炔丙基甘氨酸（Pra），叠氮鸟氨酸（OrnN3）或L-叠氮基赖氨酸（Az4）和V1-V2-V3-V4-V5（纤维素酶），在体外和纤维素中选择性结合癌蛋白K-Ras G12D 是具有选自SEQ ID NO：1-20的序列的氨基酸可变区。

公开(公告)号：US11365219B2

公开(公告)日：2022-06-21

申请号：US16908204

申请日：2020-06-22

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Rosemary Dyane Rohde ,  Arundhati Nag ,  Samir Das ,  Aiko Umeda

IPC: C07K7/64 ,  A61K49/00 ,  C07K5/06 ,  C07K5/08 ,  A61K51/08 ,  C07K5/10 ,  C07K1/04 ,  C07K7/56 ,  C07K14/00 ,  G01N33/573 ,  G01N33/68

Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.

公开(公告)号：US11168115B2

公开(公告)日：2021-11-09

申请号：US14310201

申请日：2014-06-20

Applicant: California Institute of Technology

Inventor： James R. Heath ,  Rosemary Dyane Rohde ,  Arundhati Nag ,  Samir Das ,  Aiko Umeda

IPC: C07K7/64 ,  A61K51/08 ,  A61K49/00 ,  C07K5/06 ,  C07K5/08 ,  C07K1/04 ,  C07K5/10 ,  C07K7/56 ,  C07K14/00 ,  G01N33/573 ,  G01N33/68

Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.