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公开(公告)号：US20180319844A1
公开(公告)日：2018-11-08
申请号：US16031840
申请日：2018-07-10
Applicant: California Institute of Technology
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
IPC: C07K7/64 , C07K7/06 , C07K14/82 , G01N33/574
CPC classification number: C07K7/64 , A61K38/00 , C07K7/06 , C07K14/82 , G01N33/5748 , G01N2333/82 , G01N2333/914 , G01N2500/04
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
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公开(公告)号：US10017540B2
公开(公告)日：2018-07-10
申请号：US15068528
申请日：2016-03-11
Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
CPC classification number: C07K7/64 , A61K38/00 , C07K7/06 , C07K14/82 , G01N33/5748 , G01N2333/82 , G01N2333/914 , G01N2500/04
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pra), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
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公开(公告)号：US20150078999A1
公开(公告)日：2015-03-19
申请号：US14310201
申请日：2014-06-20
Applicant: California Institute of Technology
Inventor： James R. Heath , Rosemary Dyane Rohde , Arundhati Nag , Samir Das , Aiko Umeda
IPC: C07K7/64 , C07K14/00 , A61K51/08 , G01N33/68 , G01N33/573
CPC classification number: C07K7/64 , A61K49/0032 , A61K49/0041 , A61K49/0043 , A61K51/08 , A61K51/088 , C07K1/047 , C07K5/06 , C07K5/08 , C07K5/10 , C07K7/56 , C07K14/001 , G01N33/573 , G01N33/6842 , G01N2333/912
Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.
Abstract translation: 公开了具有作为蛋白质结合剂活性的肽。 肽具有以下结构（I）：包括其立体异构体，药学上可接受的盐和前药，其中R，R 1，L 1，L 2，G，M，Y 1 Y 2和SEQ如本文所定义。 还公开了与这种肽的制备和使用相关的方法，以及包含这些肽的药物组合物。
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Patent Agency Ranking
公开(公告)号：US20220380409A1
公开(公告)日：2022-12-01
申请号：US17844456
申请日：2022-06-20
Applicant: California Institute of Technology
Inventor： James R. Heath , Rosemary Dyane Rohde , Arundhati Nag , Samir Das , Aiko Umeda
IPC: C07K7/64 , A61K49/00 , C07K5/06 , C07K5/08 , A61K51/08 , C07K1/04 , C07K5/10 , C07K7/56 , C07K14/00 , G01N33/573 , G01N33/68
Abstract: Peptides having activity as protein binding agents are disclosed. The peptides have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein R, R1, L1, L2, G, M, Y1 Y2 and SEQ are as defined herein. Methods associated with preparation and use of such peptides, as well as pharmaceutical compositions comprising such peptides, are also disclosed.
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公开(公告)号：US10913774B2
公开(公告)日：2021-02-09
申请号：US16031840
申请日：2018-07-10
Applicant: California Institute of Technology
Inventor： Ryan K. Henning , Ashwin N. Ram , Samir Das , Arundhati Nag , James R. Heath
IPC: A61K38/00 , C07K7/64 , G01N33/574 , C07K14/82 , C07K7/06
Abstract: Cyclic peptides represented by (Formula 1) selectively bind the oncoprotein K-Ras G12D in vitro and in cellulo, where Z1 and Z2 are each L-propargylglycine (Pm), azidoornithine (OrnN3), or L-azidolysine (Az4), and V1-V2-V3-V4-V5 is an amino acid variable region having a sequence selected from the group consisting of SEQ ID NOs: 1-20.
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16.发明申请IL-17F-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开IL-17F特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20170052199A1
公开(公告)日：2017-02-23
申请号：US15211759
申请日：2016-07-15
Applicant: California Institute of Technology , Indi Molecular, Inc.
Inventor： James R. Heath , Heather Agnew , Blake Farrow , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das , Bert Tsunyin Lai , Suresh Mark Pitram
CPC classification number: G01N33/6869 , C07K7/06 , C07K7/64 , C07K14/54 , C07K2319/00 , G01N2333/54
Abstract: The present application provides stable peptide-based IL-17F capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
Abstract translation: 本申请提供稳定的基于肽的IL-17F捕获剂和用作检测剂的方法。 该应用进一步提供了制造IL-17F捕获剂的方法。
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17.发明公开公开(公告)号：US20240337665A1
公开(公告)日：2024-10-10
申请号：US18335819
申请日：2023-06-15
Inventor： Heather Agnew , Bert Tsunyin Lai , Suresh Mark Pitram , Blake Farrow , James R. Heath , David Bunck , Jingxin Liang , Arundhati Nag , Samir Das
CPC classification number: G01N33/6869 , C07K7/06 , C07K14/54
Abstract: The present application provides stable peptide-based IL-17F and IL-17A capture agents and methods of use as detection agents. The application further provides methods of manufacturing IL-17F capture agents.
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18.发明申请PHOSPHORYLATED AKT-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING 审中-公开磷酸钾特异性捕获剂，组合物和使用和制备方法公开(公告)号：US20150219657A1
公开(公告)日：2015-08-06
申请号：US14485243
申请日：2014-09-12
Applicant: California Institute of Technology
Inventor： James R. Heath , Arundhati Nag , Samir Das , Joseph O. Varghese , Ryan K. Henning
IPC: G01N33/574 , G01N33/58 , C07K7/06
Abstract: The present application provides stable peptide-based Akt capture agents and methods of use as detection and diagnosis agents and in the treatment of diseases and disorders. The application further provides methods of manufacturing Akt capture agents using iterative on-bead in situ click chemistry.
Abstract translation: 本申请提供了稳定的基于肽的Akt捕获剂以及用作检测和诊断试剂以及用于治疗疾病和病症的方法。 该应用进一步提供了使用迭代的珠粒原位点击化学制造Akt捕获剂的方法。
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