公开(公告)号：US10905548B2

公开(公告)日：2021-02-02

申请号：US16135770

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US20190083262A1

公开(公告)日：2019-03-21

申请号：US16135447

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： LLIA HARITON ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A heart valve delivery system may be provided. The heart valve delivery system may include at least a first catheter movable relative to second and third catheters, arranged in a telescoping configuration. The second catheter may be movable relative to and extend from the distal end of the third catheter. The delivery system may include a first adjustable flexure radius associated with the second catheter, and a second flexure radius. The delivery system may include at one control handle assembly configured to permit the catheters to rotate together, independently adjust the first and second flexure radii, cause relative axial movement between the catheters, and permit the ejector to cause relative movement between a heart valve and a capsule connected to the first catheter.

公开(公告)号：US12232958B2

公开(公告)日：2025-02-25

申请号：US18234745

申请日：2023-08-16

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts, has an upstream end and a downstream end, and defines a lumen. The valve body is shaped so as to define a circumferential row of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. Exactly two of the four sides of each of the four-sided closed cells are double-strutted. Other embodiments are also described.

公开(公告)号：US12090048B2

公开(公告)日：2024-09-17

申请号：US18371191

申请日：2023-09-21

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  AViram Baum ,  Boaz Harari

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2412 ,  A61F2/2427 ,  A61F2/243 ,  A61F2/2436

Abstract: A prosthetic valve includes a tubular portion coupled to an upstream support portion, and ventricular legs. The prosthetic valve is transitionable from a compressed state into a partially-expanded state in which (1) a downstream surface of the support portion defines (i) an annular concave region extending radially between a concave-region inner radius and a concave-region outer radius, and (ii) an annular convex region, radially outward from the annular concave region, extending radially between a convex-region inner radius and a convex-region outer radius, and (2) the tip of each leg is disposed radially between the concave-region inner radius and the concave-region outer radius. In a fully-expanded state each leg's tip is disposed radially between the convex-region inner radius and the convex-region outer radius. Other embodiments are also described.

公开(公告)号：US11872131B2

公开(公告)日：2024-01-16

申请号：US17839538

申请日：2022-06-14

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Meni Iamberger

IPC: A61F2/24

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2433 ,  A61F2210/0014 ,  A61F2250/0048 ,  A61F2250/0063 ,  A61F2250/0065

Abstract: Embodiments of the present disclosure include a method for use at a native valve of a heart of a subject. At a distal portion of a delivery tool, a balloon is coupled to a shaft. The distal portion is advanced to the heart with an implant and the balloon disposed within a capsule. The implant includes a tubular frame and one or more shape-memory flanges. The tubular frame is compressed around the balloon, and the flanges are constrained within a downstream capsule-portion of the capsule. The flanges are exposed from the downstream capsule-portion such that the flanges automatically deflect radially outward. Subsequently, the flanges are pressed against a downstream surface of the native valve by moving the implant in an upstream direction. While the flanges are in contact with the downstream surface, the tubular frame is plastically expanded radially by inflating the balloon. Other embodiments are also described.

公开(公告)号：US11819405B2

公开(公告)日：2023-11-21

申请号：US16135969

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/246 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/007

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body and a plurality of atrial anchoring arms and a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs and fastened to at least one arm. The cuff may be configured to extend radially outward beyond a terminal end of at least one arm when fully inflated with blood.

公开(公告)号：US11337804B2

公开(公告)日：2022-05-24

申请号：US16136074

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an annular valve body, as well as a plurality of ventricular anchoring legs and a plurality of atrial anchoring arms configured to extend radially outward from the annular valve body. The ventricular anchoring legs and grasping segments of the atrial anchoring arms may be configured to substantially restrict axial movement of the annular valve body within the native heart valve. In addition, anchoring segments of the atrial anchoring arms may be configured for lateral deformation relative to the native heart valve.

公开(公告)号：US11318014B2

公开(公告)日：2022-05-03

申请号：US16135619

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve delivery system may be provided. The prosthetic valve delivery system may include a first catheter and a first steering mechanism configured to bend the first catheter within a first steering plane. The prosthetic valve delivery system may also include a second catheter coaxially arranged within the first catheter and a second steering mechanism configured to bend the second catheter within a second steering plane, different from the first steering plane. Moreover, the prosthetic valve delivery system may include a capsule positioned distal to both the first catheter and the second catheter. The capsule may be configured to retain a prosthetic valve therein during transvascular advancement of the capsule.

公开(公告)号：US11304805B2

公开(公告)日：2022-04-19

申请号：US16135979

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: A prosthetic valve for implantation within a native mitral valve may be provided. The prosthetic valve may include an annular valve body, a plurality of atrial anchoring arms configured to extend radially outward from the valve body, and a plurality of ventricular anchoring legs configured to extend radially outward from the valve body. The prosthetic valve may also include a blood-inflatable cuff situated between the arms and legs. The cuff may be configured to substantially fill a volume between the arms and the legs when the cuff is fully inflated with blood.

公开(公告)号：US20210085457A1

公开(公告)日：2021-03-25

申请号：US17114771

申请日：2020-12-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.