公开(公告)号：US12127757B2

公开(公告)日：2024-10-29

申请号：US17429446

申请日：2019-12-23

Applicant: CARDIOVALVE LTD.

Inventor： Michael Albitov ,  Meni Iamberger ,  Ilia Hariton

IPC: A61B17/32

CPC classification number: A61B17/32 ,  A61B2217/005 ,  A61B2560/0214 ,  A61B2560/0425

Abstract: Embodiments of the present disclosure include a method for conditioning ex vivo pericardial tissue that has a parietal side and a fibrous side from which fibers extend. A blade assembly includes a blade head having a blade array and a face that defines gaps therein. The parietal side of the tissue is placed downward against a support plate, and a motor is operated to move the blade array with respect to the face. The face contacts the tissue such that the fibers protrude through the gaps and into the blade head. The blade array shears the fibers that protrude through the gaps into the blade head, yielding sheared fibers. Other embodiments are also described.

公开(公告)号：US12029646B2

公开(公告)日：2024-07-09

申请号：US18216391

申请日：2023-06-29

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/24 ,  A61F2/2427 ,  A61F2/2436 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2220/0075 ,  A61F2250/0003 ,  A61F2250/0039

Abstract: A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts, has an upstream end and a downstream end, and defines a lumen. The valve body is shaped so as to define a circumferential row of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. Each of the four sides of each of the four-sided closed cells is double-strutted. Other embodiments are also described.

公开(公告)号：US11872124B2

公开(公告)日：2024-01-16

申请号：US18125350

申请日：2023-03-23

Applicant: CARDIOVALVE LTD.

Inventor： Maxim Karalnik ,  Michael Albitov ,  Oren Shua ,  Meni Iamberger ,  Ilia Hariton

IPC: A61F2/95 ,  A61F2/24 ,  B21D39/04

CPC classification number: A61F2/2415 ,  A61F2/2427 ,  A61F2/9522 ,  A61F2/9524 ,  A61F2/9525 ,  B21D39/048 ,  A61F2210/0014 ,  Y10T29/49865

Abstract: Apparatus for crimping a frame of an implant includes a crimping assembly having a bath having a floor, and one or more side-walls extending upward from the floor to a side-wall height. A crimping mechanism that defines a crimping aperture is attached to the bath such that the crimping aperture is disposed within the bath below the side-wall height. The crimping mechanism further comprises a handle and is actuatable by moving the handle circumferentially around the crimping mechanism. Actuation of the crimping mechanism transitions the crimping aperture from its open state to its narrowed state. Other embodiments are also described.

公开(公告)号：US11864996B2

公开(公告)日：2024-01-09

申请号：US17114771

申请日：2020-12-08

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

CPC classification number: A61F2/2427 ,  A61F2/243 ,  A61F2/2436 ,  A61F2/2445 ,  A61F2/2454 ,  A61F2/2463 ,  A61F2/246 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/2466 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2250/007

Abstract: An expandable prosthetic valve for implantation within a native heart valve may be provided. The prosthetic valve may include an expandable annular valve body. The valve body may include an atrial inlet opening and a ventricular outlet opening. The valve body may additionally include a plurality of tissue anchors extending from the valve body. The prosthetic valve may additionally include a flexible annular protective sleeve positioned about the rim of the valve body outlet opening and affixed to the outlet opening.

公开(公告)号：US20230390053A1

公开(公告)日：2023-12-07

申请号：US18234745

申请日：2023-08-16

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/24 ,  A61F2220/0075 ,  A61F2/2427 ,  A61F2250/0039 ,  A61F2210/0014 ,  A61F2220/0008 ,  A61F2/2436 ,  A61F2250/0003

Abstract: A prosthetic valve is provided that includes a tubular valve body and a plurality of prosthetic leaflets disposed within a lumen of the valve body. The valve body includes struts, has an upstream end and a downstream end, and defines a lumen. The valve body is shaped so as to define a circumferential row of four-sided closed cells. Each of the four-sided closed cells is defined by some of the struts, which are shaped so as to collectively define the following four sides: a left upstream side, a right upstream side, a left downstream side, and a right downstream side. Exactly two of the four sides of each of the four-sided closed cells are double-strutted. Other embodiments are also described.

公开(公告)号：US11801135B2

公开(公告)日：2023-10-31

申请号：US17141853

申请日：2021-01-05

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/95 ,  A61F2/915

CPC classification number: A61F2/2436 ,  A61F2/243 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2/9517 ,  A61F2002/91575 ,  A61F2220/0016 ,  A61F2220/0025

Abstract: A method includes percutaneously advancing an implant to a native heart valve of a subject, the implant being housed in a compressed state within a delivery tool. Next, the method includes unhousing a longitudinally-intermediate portion of the implant, the longitudinally-intermediate portion being longitudinally between a longitudinally-proximal portion of the implant and a longitudinally distal portion of the implant. Subsequently, the longitudinally-proximal portion of the implant is unhoused. Subsequently, the longitudinally-distal portion of the implant is unhoused. By unhousing flanges of the implant, the flanges automatically expand. Upon the flanges expanding, a proximal end of each flange extends radially outward from a central longitudinal axis of the implant and longitudinally in a proximal direction. Other applications are also described.

公开(公告)号：US11648122B2

公开(公告)日：2023-05-16

申请号：US17353063

申请日：2021-06-21

Applicant: CARDIOVALVE LTD.

Inventor： Boaz Harari ,  Ilia Hariton

IPC: A61F2/24 ,  G01N3/04 ,  G01L1/24 ,  G01B11/02 ,  H04N7/18 ,  A61F2/76 ,  G01B11/14

CPC classification number: A61F2/2472 ,  G01L1/24 ,  G01N3/04 ,  A61F2002/7635 ,  G01B11/02 ,  G01B11/14 ,  H04N7/18

Abstract: Apparatus (20) for testing a prosthetic leaflet (10) includes a bar (22); a light source (24); a detector (26); an actuator (40); a gauge (28); a display (82); and circuitry (84). The leaflet is draped over the bar. The light source emits a beam of light (32). The detector detects the beam, and generates a detection-signal indicative of detection of the beam. Actuation of the actuator moves the bar with respect to the beam. The gauge measures an elevation of the bar above the beam, the elevation changing with the moving of the bar by the actuator. The circuitry is configured: (i) to receive the measured elevation from the gauge, (ii) to receive the detection-signal from the detector, and (iii) in response to the detection-signal, to drive the display to display the elevation that was measured when the detection-signal was received by the circuitry.

公开(公告)号：US20220304804A1

公开(公告)日：2022-09-29

申请号：US17841912

申请日：2022-06-16

Applicant: CARDIOVALVE LTD.

Inventor： Tal HAMMER ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24

Abstract: A rod (508) is transfemorally advanceable to the heart. An implant (460) comprises (i) a first frame (462), compressed around a first longitudinal site of a distal portion of the rod, (ii) a second frame (464), compressed around a third longitudinal site of the distal portion, (iii) a valve member (50), disposed within the second frame, and (iv) a flexible sheet (466), coupling the first frame to the second frame, and disposed around a second longitudinal site of the distal portion, the second longitudinal site being between the first longitudinal site and the third longitudinal site. An extracorporeal controller (569) is coupled to a proximal portion of the rod, and is operably coupled to the distal portion of the rod. Operating the controller bends the distal portion of the rod causing articulation between the frames. Other embodiments are also described.

公开(公告)号：US11382746B2

公开(公告)日：2022-07-12

申请号：US16768909

申请日：2018-12-12

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari

IPC: A61F2/24

Abstract: Embodiments of the present disclosure include apparatus for use at a native valve of a heart of a subject. A delivery tool has a shaft, a capsule disposed at a distal portion of the tool, and a balloon that is disposed within the capsule and coupled to the shaft. A tubular frame of a prosthetic valve is compressed around the balloon, such that shape-memory flanges of the prosthetic valve, and a shape-memory upstream support portion of the prosthetic valve, are each constrained within a respective capsule-portion of the capsule. The capsule is openable by moving the capsule-portions apart, such that the flanges and the upstream support portion automatically deflect radially outward, while the tubular frame remains compressed around the balloon, and inflation of the balloon plastically expands the tubular frame radially. Other embodiments are also described.

公开(公告)号：US11304806B2

公开(公告)日：2022-04-19

申请号：US16136082

申请日：2018-09-19

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Boaz Harari

IPC: A61F2/24

Abstract: Prosthetic valves and methods of implanting prosthetic valves may be provided, including an expandable prosthetic valve for implantation within a native heart valve. The prosthetic valve may include an annular valve body and atrial anchoring arms configured to extend radially outward from the annular valve body. Each atrial anchoring arm may have a proximal arm end and a distal arm end. The flexibility of at least one atrial anchoring arm may vary substantially from the proximal arm end thereof to the distal arm end thereof. The prosthetic valve may also include a plurality of ventricular anchoring legs configured to extend radially outward from the annular valve body. Each ventricular anchoring leg may have a proximal leg end and a distal leg end. Each ventricular anchoring leg may have a substantially constant flexibility from the proximal leg end to the distal leg end.