公开(公告)号：US10266847B2

公开(公告)日：2019-04-23

申请号：US15820741

申请日：2017-11-22

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Pin Wang ,  Lili Yang ,  David Baltimore

IPC: A01N63/00 ,  A61K48/00 ,  C12N15/86 ,  A61K31/70 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  C07K14/005 ,  A61K35/76 ,  A61K39/21 ,  C12N7/00 ,  A61K39/00

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.

公开(公告)号：US09994867B2

公开(公告)日：2018-06-12

申请号：US14338947

申请日：2014-07-23

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： David Baltimore ,  Pin Wang ,  Lili Yang

IPC: A61K39/12 ,  C12N15/867 ,  C07K14/18 ,  C07K16/18 ,  C12N15/86 ,  C07K16/28 ,  A61K39/00

CPC classification number: C12N15/86 ,  A61K2039/505 ,  C07K16/2887 ,  C07K2317/53 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/03 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2799/027 ,  C12N2810/80 ,  C12N2810/851 ,  C12N2810/859 ,  Y02A50/386 ,  Y02A50/396

Abstract: Methods and compositions are provided for delivering a polynucleotide encoding a gene of interest to a target cell using a virus. The virus envelope comprises a cell-specific binding determinant that recognizes and binds to a component on the target cell surface, leading to endocytosis of the virus. A separate fusogenic molecule is also present on the envelope and facilitates delivery of the polynucleotide across the membrane and into the cytosol of the target cell. The methods and related compositions can be used for treating patients having suffering from a wide range of conditions, including infection, such as HIV; cancers, such as non-Hodgkin's lymphoma and breast cancer; and hematological disorders, such as severe combined immunodeficiency.

公开(公告)号：US20160340692A1

公开(公告)日：2016-11-24

申请号：US15051907

申请日：2016-02-24

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Pin Wang ,  Lili Yang ,  David Baltimore

IPC: C12N15/86 ,  A61K35/76 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K39/21 ,  C12N7/00 ,  C07K14/005

CPC classification number: C12N15/86 ,  A61K31/70 ,  A61K35/76 ,  A61K38/177 ,  A61K38/1774 ,  A61K38/178 ,  A61K38/1793 ,  A61K38/191 ,  A61K38/193 ,  A61K38/20 ,  A61K38/2013 ,  A61K38/2026 ,  A61K38/204 ,  A61K38/2046 ,  A61K38/2086 ,  A61K39/21 ,  A61K2039/5256 ,  C07K14/005 ,  C12N7/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15041 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2770/36122 ,  C12N2770/36134 ,  C12N2810/609 ,  C12N2810/855 ,  Y02A50/386 ,  Y02A50/396 ,  Y02A50/401 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/41 ,  Y02A50/412 ,  Y02A50/423 ,  Y02A50/466 ,  Y02A50/475 ,  Y02A50/48 ,  Y02A50/481 ,  Y02A50/492 ,  A61K2300/00

Abstract: Methods and compositions are provided for delivery of a polynucleotide encoding a gene of interest, typically an antigen, to a dendritic cell (DC). The virus envelope comprises a DC-SIGN specific targeting molecule. The methods and related compositions can be used to treat patients suffering from a wide range of conditions, including infection, such as HIV/AIDS, and various types of cancers.