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    Cytotoxic antibodies directed against antibodies inhibiting factor VIII
    11.
    发明授权
    Cytotoxic antibodies directed against antibodies inhibiting factor VIII 失效
    针对抗体抑制因子VIII的细胞毒性抗体

    公开(公告)号：US08038993B2

    公开(公告)日：2011-10-18

    申请号：US12084459

    申请日：2006-11-02

    申请人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    发明人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    IPC分类号： A61K39/395

    CPC分类号： C07K16/4208 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

    摘要： The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 1, and the variable region of each of the heavy chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 2, the constant regions of the light chains and the heavy chains being constant regions from a non-murine species. The invention also relates to the use of said antibody for activating the FcγRIII receptors of cytotoxic immune cells, and to the production of a medicament especially for the treatment of haemophilia A.

    摘要翻译： 本发明涉及靶向抑制人因子VIII的抗体的抗独特型抗体，所述抗体靶向人因子VIII的C2区，其轻链的可变区由序列的核酸 其至少70％与核酸SEQ ID NO：1的鼠序列相同，并且其每个重链的可变区由核酸序列编码，其中至少70％与小鼠相同 核酸序列SEQ ID NO：2，轻链和重链的恒定区是来自非鼠类的恒定​​区。 本发明还涉及所述抗体用于激活细胞毒性免疫细胞的FcγRIII受体的用途，以及特别用于治疗血友病A的药物的生产。

    CYTOTOXIC ANTIBODIES DIRECTED AGAINST ANTIBODIES INHIBITING FACTOR VIII
    13.
    发明申请
    CYTOTOXIC ANTIBODIES DIRECTED AGAINST ANTIBODIES INHIBITING FACTOR VIII 审中-公开
    针对抗体抑制因子VIII的细胞毒素抗体

    公开(公告)号：US20110274684A1

    公开(公告)日：2011-11-10

    申请号：US13104939

    申请日：2011-05-10

    申请人： Christian BEHRENS ,  Christine Gaucher ,  Christophe De Romeuf

    发明人： Christian BEHRENS ,  Christine Gaucher ,  Christophe De Romeuf

    IPC分类号： C07K16/42 ,  A61P7/04 ,  C12N5/10 ,  A61K39/395

    CPC分类号： C07K16/4208 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

    摘要： The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human fact VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 1, and the variable region of each of the heavy chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 2, the constant regions of the light chains and the heavy chains being constant regions from a non-murine species. The invention also relates to the use of said antibody for activating the FcγRIII receptors of cytotoxic immune cells, and to the production of a medicament especially for the treatment of haemophilia A.

    摘要翻译： 本发明涉及靶向抑制人事实VIII的抗体的抗独特型抗体，所述抗体靶向人因子VIII的C2区的所述抑制性抗体，其每个轻链的可变区由序列的核酸 其至少70％与核酸SEQ ID NO：1的鼠序列相同，并且其每个重链的可变区由核酸序列编码，其中至少70％与小鼠相同 核酸序列SEQ ID NO：2，轻链和重链的恒定区是来自非鼠类的恒定​​区。 本发明还涉及所述抗体用于激活细胞毒性免疫细胞的FcγRIII受体的用途，以及特别是用于治疗血友病A的药物的生产。

    Cytokine production-inducing antibody
    15.
    发明申请
    Cytokine production-inducing antibody 有权
    细胞因子产生诱导抗体

    公开(公告)号：US20050249732A1

    公开(公告)日：2005-11-10

    申请号：US10527665

    申请日：2003-09-15

    申请人： Christophe de Romeuf ,  Christine Gaucher ,  Arnaud Glacet ,  Frederic Dhainaut ,  Dominique Bourel

    发明人： Christophe de Romeuf ,  Christine Gaucher ,  Arnaud Glacet ,  Frederic Dhainaut ,  Dominique Bourel

    IPC分类号： G01N33/50 ,  G01N33/68 ,  G01N33/53 ,  A61K39/395 ,  G01N33/567

    CPC分类号： G01N33/6869 ,  C07K16/2833 ,  C07K16/2887 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/732 ,  G01N33/5047 ,  G01N33/6863 ,  G01N2333/70535

    摘要： The invention relates to a method of measuring the activation of an effector cell belonging to the immune which may or may not be transformed, using a monoclonal (AcMo) or polyclonal antibody. The invention is characterised in that it consists in: bringing into contact (i) CD16 receptor-expressing cells in a reaction medium in the presence of the antibody and (ii) the antigen of said antibody, and measuring the quantity of at least one cytokine produced by the CD16 receptor-expressing cell. The invention also relates to the selection of an antibody capable of inducing the expression of cytokines and interleukins, such as IFN? or IL2 which are intended for the treatment of autoimmune and inflammatory diseases, cancers and infections by pathogens.

    摘要翻译： 本发明涉及使用单克隆（AcMo）或多克隆抗体测量属于免疫的效应细胞的活化的方法，其可以或可能不被转化。 本发明的特征在于：其在抗体存在下使反应介质中的CD16受体表达细胞接触（i）和（ii）所述抗体的抗原，并测量至少一种细胞因子的量 由CD16受体表达细胞产生。 本发明还涉及能够诱导细胞因子和白介素（例如IFNα）表达的抗体的选择。 或IL2，其用于治疗自身免疫性和炎性疾病，癌症和病原体的感染。