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    Antibody for ADCC And Inducing Cytokine Production
    1.
    发明申请
    Antibody for ADCC And Inducing Cytokine Production 审中-公开
    ADCC抗体和诱导细胞因子生产

    公开(公告)号：US20100145026A1

    公开(公告)日：2010-06-10

    申请号：US12576202

    申请日：2009-10-08

    申请人： Christophe de ROMEUF ,  Arnaud GLACET ,  Jacques LIROCHON ,  Dominique BOUREL

    发明人： Christophe de ROMEUF ,  Arnaud GLACET ,  Jacques LIROCHON ,  Dominique BOUREL

    IPC分类号： C07K16/00

    CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K2317/41 ,  C07K2317/732

    摘要： The invention concerns chimeric monoclonal antibodies, humanized or human produced in selected cell lines, said antibodies exhibiting high affinity for the CD16 receptor of effector cells of the immune system and hence capable of inducing high ADCC, but also the property of inducing cytokine and interleukin secretion, in particular IFNγ, which can enhance the ADCC activity of effector cells and hence be used for treating cancers and infections by pathogenic agents.

    摘要翻译： 本发明涉及在选择的细胞系中产生的人源化或人类的嵌合单克隆抗体，所述抗体对免疫系统的效应细胞的CD16受体表现出高亲和力，因此能够诱导高ADCC，而且还诱导诱导细胞因子和白介素分泌的性质 ，特别是IFNγ，其可以增强效应细胞的ADCC活性，因此可用于治疗癌症和病原体感染。

    Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII
    3.
    发明申请
    Cytotoxic Antibodies Directed Against Antibodies Inhibiting Factor VIII 失效
    针对抗体抑制因子VIII的细胞毒性抗体

    公开(公告)号：US20090130094A1

    公开(公告)日：2009-05-21

    申请号：US12084459

    申请日：2006-11-02

    申请人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    发明人： Christian Behrens ,  Christine Gaucher ,  Christophe De Romeuf

    IPC分类号： A61K39/395 ,  C07K16/42 ,  C12N15/13 ,  A61P7/04 ,  C12N5/00

    CPC分类号： C07K16/4208 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565

    摘要： The invention relates to an anti-idiotypical antibody targeting an antibody inhibiting the human factor VIII, said inhibiting antibody targeting the C2 region of the human factor VIII, the variable region of each of the light chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 1, and the variable region of each of the heavy chains thereof being encoded by a sequence of nucleic acids of which at least 70% is identical to the murine sequence of nucleic acids SEQ ID NO: 2, the constant regions of the light chains and the heavy chains being constant regions from a non-murine species. The invention also relates to the use of said antibody for activating the FcγRIII receptors of cytotoxic immune cells, and to the production of a medicament especially for the treatment of haemophilia A.

    摘要翻译： 本发明涉及靶向抑制人因子VIII的抗体的抗独特型抗体，所述抗体靶向人因子VIII的C2区，其轻链的可变区由序列的核酸 其至少70％与核酸SEQ ID NO：1的鼠序列相同，并且其每个重链的可变区由核酸序列编码，其中至少70％与小鼠相同 核酸序列SEQ ID NO：2，轻链和重链的恒定区是来自非鼠类的恒定​​区。 本发明还涉及所述抗体用于激活细胞毒性免疫细胞的FcγRIII受体的用途，以及特别是用于治疗血友病A的药物的生产。

    Antibody for adcc and inducing cytokine production
    4.
    发明申请
    Antibody for adcc and inducing cytokine production 审中-公开
    用于adcc和诱导细胞因子产生的抗体

    公开(公告)号：US20060127392A1

    公开(公告)日：2006-06-15

    申请号：US10527664

    申请日：2003-09-15

    申请人： Christophe de Romeuf ,  Arnaud Glacet ,  Jacques Lirochon ,  Dominique Bourel

    发明人： Christophe de Romeuf ,  Arnaud Glacet ,  Jacques Lirochon ,  Dominique Bourel

    IPC分类号： A61K39/395 ,  C07K16/28 ,  C07K16/24

    CPC分类号： C07K16/2833 ,  A61K2039/505 ,  C07K2317/41 ,  C07K2317/732

    摘要： The invention concerns chimeric monoclonal antibodies, humanized or human produced in selected cell lines, said antibodies exhibiting high affinity for the CD16 receptor of effector cells of the immune system and hence capable of inducing high ADCC, but also the property of inducing cytokine and interleukin secretion, in particular IFNγ, which can enhance the ADCC activity of effector cells and hence be used for treating cancers and infections by pathogenic agents.

    摘要翻译： 本发明涉及在选择的细胞系中产生的人源化或人类的嵌合单克隆抗体，所述抗体对免疫系统的效应细胞的CD16受体表现出高亲和力，因此能够诱导高ADCC，而且还诱导诱导细胞因子和白介素分泌的性质 ，特别是IFNgamma，其可以增强效应细胞的ADCC活性，因此可用于治疗癌症和病原体感染。