公开(公告)号：US20170335018A1

公开(公告)日：2017-11-23

申请号：US15521028

申请日：2015-10-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe

IPC: C08B13/00

CPC classification number: C08B13/00 ,  A61K9/2866 ,  A61K9/2886 ,  A61K47/38 ,  C08L1/32 ,  C09D101/32

Abstract: A process for producing a cellulose ether acetate succinate comprises the step of reacting a cellulose ether with acetic anhydride, succinic anhydride and an depolymerizing agent, wherein the cellulose ether has an initial viscosity of at least 50 mPa-s, measured as a 2 weight-% solution in water at 20° C., and the reaction of the cellulose ether with acetic anhydride, succinic anhydride and the depolymerizing agent is conducted simultaneously or in sequence in one reaction device.

公开(公告)号：US09616036B2

公开(公告)日：2017-04-11

申请号：US14390046

申请日：2013-04-08

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Roland Adden ,  Oliver Petermann ,  Robert L. Sammler ,  David E. Wallick

IPC: A61K31/167 ,  A61K9/20 ,  C08B11/08 ,  C08B11/193 ,  C08L1/28

CPC classification number: A61K31/167 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095 ,  C08B11/08 ,  C08B11/193 ,  C08L1/284

Abstract: A sustained release dosage form comprises an active ingredient blended with a polymeric matrix. At least a portion of the polymeric matrix is formed by a cellulose ether having an onset dissolution temperature of at least 40° C., having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.31 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

公开(公告)号：US09453081B2

公开(公告)日：2016-09-27

申请号：US14384220

申请日：2013-03-12

Applicant: Dow Global Technologies LLC

Inventor： Matthias Sprehe ,  Oliver Petermann ,  Robert B. Appell

IPC: C08B3/00 ,  C08B3/12 ,  C08B3/28 ,  C08B13/00 ,  C08B11/20

CPC classification number: C08B13/00 ,  C08B11/20

Abstract: A reaction product mixture is obtained from a reaction of (a) a cellulose ether with (b) an aliphatic monocarboxylic acid anhydride or with a di- or tricarboxylic acid anhydride or with a combination of an aliphatic monocarboxylic acid anhydride and a di- or tricarboxylic acid anhydride in the presence of (c) an aliphatic carboxylic acid. A process for precipitating an esterified cellulose ether from this reaction product mixture comprises the step of contacting the reaction product mixture with water and subjecting the combination of water and the reaction product mixture to a shear rate of at least 800 s−1. The precipitated esterified cellulose ether can be recovered as a non-tacky product.

Abstract translation: 反应产物混合物由（a）纤维素醚与（b）脂肪族单羧酸酐或二羧酸或三羧酸酐的反应或与脂族一元羧酸酐和二羧酸或三羧酸的组合 （c）脂族羧酸存在下的酸酐。 从该反应产物混合物中沉淀酯化纤维素醚的方法包括使反应产物混合物与水接触并使水和反应产物混合物的组合经受至少800s -1的剪切速率的步骤。 沉淀的酯化纤维素醚可以作为非粘性产物回收。

公开(公告)号：US09364546B2

公开(公告)日：2016-06-14

申请号：US14389838

申请日：2013-04-08

Applicant: Dow Global Technologies LLC

Inventor： Nicholas S. Grasman ,  True L. Rogers ,  Oliver Petermann ,  Meinolf Brackhagen ,  Roland Adden

IPC: A61K9/14 ,  A61K47/38 ,  C08B11/193 ,  C08L1/28 ,  A61K9/16 ,  A61K9/20 ,  A61K31/192 ,  B29C47/00 ,  B29K1/00 ,  B29K105/00

CPC classification number: A61K47/38 ,  A61K9/1652 ,  A61K9/2095 ,  A61K31/192 ,  B29C47/004 ,  B29C47/0066 ,  B29C2793/009 ,  B29K2001/08 ,  B29K2105/0035 ,  C08B11/193 ,  C08L1/28 ,  C08L1/284

Abstract: A melt-extruded polymer composition comprising a) at least one cellulose ether, b) one or more active ingredients and c) one or more optional additives, wherein said at least one cellulose ether has an MS (hydroxyalkyl) of 0.05 to 0.55 and hydroxyl groups of anhydroglucose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.32 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Abstract translation: 一种熔融挤出的聚合物组合物，其包含a）至少一种纤维素醚，b）一种或多种活性成分和c）一种或多种任选的添加剂，其中所述至少一种纤维素醚具有0.05至0.55的MS（羟烷基）和羟基 脱水葡萄糖单元的基团被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.32以下，其中s23是脱水葡萄糖单元的摩尔分数，其中只有2位和3位的两个羟基， 脱水葡萄糖单元的位置被甲基取代，其中s26是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和6-位上的两个羟基仅被甲基取代。

公开(公告)号：US20150057358A1

公开(公告)日：2015-02-26

申请号：US14390046

申请日：2013-04-08

Applicant: Dow Global Technologies LLC

Inventor： Meinolf Brackhagen ,  Roland Adden ,  Oliver Petermann ,  Robert L. Sammler ,  David E. Wallick

IPC: A61K31/167 ,  A61K9/20

CPC classification number: A61K31/167 ,  A61K9/2018 ,  A61K9/2054 ,  A61K9/2095 ,  C08B11/08 ,  C08B11/193 ,  C08L1/284

Abstract: A sustained release dosage form comprises an active ingredient blended with a polymeric matrix. At least a portion of the polymeric matrix is formed by a cellulose ether having an onset dissolution temperature of at least 40° C., having anhydroglucose units joined by 1-4 linkages and having methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that the cellulose ether has an MS (hydroxyalkyl) of 0.05 to 1.00, and hydroxyl groups of anhydrogluclose units are substituted with methyl groups such that [s23/s26−0.2*MS(hydroxyalkyl)] is 0.31 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

Abstract translation: 持续释放剂型包含与聚合物基质共混的活性成分。 聚合物基质的至少一部分由起始溶解温度为至少40℃的纤维素醚形成，其具有通过1-4键连接且具有甲基，羟基烷基和任选的烷基不同的脱水葡萄糖单元 由甲基作为取代基，使得纤维素醚具有0.05至1.00的MS（羟基烷基），并且脱甲羟基化单元的羟基被甲基取代，使得[s23 / s26-0.2 * MS（羟烷基）]为0.31以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中只有两个羟基在 脱水葡萄糖单元的2-位和6-位被甲基取代。

公开(公告)号：US10961355B2

公开(公告)日：2021-03-30

申请号：US16072673

申请日：2017-05-01

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Jin Zhao

IPC: C08J3/07 ,  A61K9/50 ,  A61K9/48 ,  A61K47/38 ,  C08L1/12 ,  A61K9/28

Abstract: An aqueous composition comprising a cellulose ether acetate being at least partially dissolved in an aqueous liquid is produced in a process, wherein an aqueous liquid is mixed with a cellulose ether acetate having a degree of substitution of acetyl groups, DSAc, of from 0.05 to 0.75 and the temperature of the mixture of the cellulose ether acetate and the aqueous liquid is set to less than 10 C to at least partially dissolve the cellulose ether acetate in the aqueous liquid.

公开(公告)号：US10730956B2

公开(公告)日：2020-08-04

申请号：US15541642

申请日：2016-01-04

Applicant: Dow Global Technologies LLC

Inventor： Roland Bayer ,  Oliver Petermann

IPC: C08B11/20 ,  C08B11/193 ,  C08B13/00

Abstract: A process for producing a water-soluble cellulose derivative of a reduced content of water-insoluble particles comprises the steps of a) reacting cellulose with an alkaline material to produce alkali cellulose, b) reacting the produced alkali cellulose with one or more derivatizing agents to produce a water-soluble cellulose derivative, c) washing the produced cellulose derivative with an aqueous liquid once or several times to provide a moist cellulose derivative having a water content of 25 to 85 percent, based on the total weight of the moist cellulose derivative, d) subjecting the moist cellulose derivative to homogenization to form the moist cellulose derivative to a paste, and e) pressing the paste through a filter of a pore size of up to 200 μm.

公开(公告)号：US10526421B2

公开(公告)日：2020-01-07

申请号：US15503600

申请日：2015-08-18

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Knarr ,  Matthias Sprehe

IPC: C08B13/00 ,  C09D101/32 ,  C08L1/32 ,  A61K9/48 ,  A61K47/38 ,  A61K9/14 ,  A61K9/20

Abstract: Esterified cellulose ethers which have i) as ester groups aliphatic monovalent acyl groups or groups of the formula —C(O)—R—COOA or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and ii) a content of not more than 0.85 weight percent acetone-insoluble esterified cellulose ether particles, when the esterified cellulose ether is present in a mixture of 12.5 weight parts of esterified cellulose ether and 87.5 weight parts of acetone at 21° C., the weight percent acetone-insoluble esterified cellulose ether particles being based on the total weight of the esterified cellulose ether, wherein iii) not more than 14 percent of the acetone-insoluble esterified cellulose ether particles have a particle size of more than 90 micrometers.

公开(公告)号：US20190184020A1

公开(公告)日：2019-06-20

申请号：US16281700

申请日：2019-02-21

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Matthias Sprehe ,  Meinolf Brackhagen ,  Steven J. Guillaudeu

IPC: A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

CPC classification number: A61K47/38 ,  A61K9/10 ,  C08B11/20 ,  C08B13/00

Abstract: A process for making esterified cellulose ethers which have i) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, ii) a weight average molecular weight Mw of from 80,000 Dalton to 350,000 Dalton, iii) a Polydispersity Mw/Mn of from 1.3 to 4.1, and iv) a viscosity of up to 4.0 mPa·s, measured as a 2.0 wt % solution of the esterified cellulose ether in 0.43 wt % aqueous NaOH at 20° C., are useful as enteric polymers for pharmaceutical dosage forms.

公开(公告)号：US20180244860A1

公开(公告)日：2018-08-30

申请号：US15755625

申请日：2016-09-12

Applicant: Dow Global Technologies LLC

Inventor： Oliver Petermann ,  Neal J. Fetner

IPC: C08J3/12 ,  C08J3/05 ,  C08K5/098 ,  C08L1/32 ,  A61J3/07

CPC classification number: C08J3/12 ,  A61J3/077 ,  A61K9/4866 ,  A61K47/38 ,  C08J3/05 ,  C08J2301/32 ,  C08K5/098 ,  C08L1/16 ,  C08L1/32 ,  C08L2203/02

Abstract: In a water-redispersible polymer powder—the polymer is at least one esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and—the polymer powder comprises from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the esterified cellulose ether(s).