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25 条记录 (耗时 0.031 秒)

    Novel Azabicyclic Aryl Derivatives
    12.
    发明申请
    Novel Azabicyclic Aryl Derivatives 失效
    新型氮杂环芳基衍生物

    公开(公告)号：US20070203117A1

    公开(公告)日：2007-08-30

    申请号：US10591871

    申请日：2005-05-10

    申请人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Daniel Timmermann

    发明人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Daniel Timmermann

    IPC分类号： A61K31/55 ,  A61K31/4745 ,  A61K31/407 ,  C07D453/02

    CPC分类号： C07D453/02

    摘要： This invention relates to novel azabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及在尼古丁乙酰胆碱受体中被发现是胆碱能配体的新的氮杂双环芳基衍生物。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel 1,4-diazabicycloalkane derivatives, their preparation and use
    13.
    发明申请
    Novel 1,4-diazabicycloalkane derivatives, their preparation and use 有权
    新型1,4-二氮杂双环链烷烃衍生物，其制备和应用

    公开(公告)号：US20060122172A1

    公开(公告)日：2006-06-08

    申请号：US10528361

    申请日：2003-09-29

    申请人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    发明人： Dan Peters ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen ,  Philip Ahring

    IPC分类号： C07D487/04 ,  A61K31/551

    CPC分类号： C07D471/08 ,  C07D487/04

    摘要： This invention relates to novel 1,4-diazabicycloalkane derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂双环链烷烃衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Heteroaryl diazacycloalkanes, their preparation and use
    14.
    发明申请
    Heteroaryl diazacycloalkanes, their preparation and use 失效
    杂芳基二氮杂环烷烃，其制备和用途

    公开(公告)号：US20060100192A1

    公开(公告)日：2006-05-11

    申请号：US11312574

    申请日：2005-12-21

    申请人： Simon Nielsen ,  Dan Peters ,  Elsebet Nielsen ,  Gunnar Olsen

    发明人： Simon Nielsen ,  Dan Peters ,  Elsebet Nielsen ,  Gunnar Olsen

    IPC分类号： A61K31/551 ,  C07D403/02

    CPC分类号： C07D401/14 ,  C07D401/04 ,  C07D403/04 ,  C07D405/14 ,  C07D417/04

    摘要： The present invention relates to novel heteroaryl diazacycloalkane derivatives, which are found to be cholinergic ligands at the nicotinic Acetyl Choline Receptors. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neurodegeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新颖的杂芳基二氮杂环烷烃衍生物，其在烟碱乙酰胆碱受体中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS）的胆碱能系统有关的疾病或病症，与平滑肌收缩相关的疾病或病症，内分泌疾病或 与神经变性相关的疾病，疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Diazabicyclic Aryl Derivatives as Cholinergy Ligands
    17.
    发明申请
    Novel Diazabicyclic Aryl Derivatives as Cholinergy Ligands 失效
    新二氮杂双环芳烃衍生物作为胆碱能配体

    公开(公告)号：US20070265271A1

    公开(公告)日：2007-11-15

    申请号：US11663967

    申请日：2005-11-29

    申请人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    发明人： Dan Peters ,  Daniel Timmermann ,  Gunnar Olsen ,  Elsebet Nielsen ,  Tino Jorgensen

    IPC分类号： A61K31/4995 ,  A61P25/00 ,  A61P25/16 ,  A61P25/24 ,  A61P3/00 ,  A61P3/04 ,  A61P43/00 ,  C07D471/08

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。