公开(公告)号：US20140341776A1

公开(公告)日：2014-11-20

申请号：US14127465

申请日：2012-07-05

申请人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Witten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

发明人： Kirk S. Schanze ,  Anand Parthasarathy ,  Subhadip Goswami ,  David G. Witten ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

IPC分类号： A01N43/82 ,  A61L2/08 ,  A01N43/10 ,  A61L2/16 ,  A01N43/647

CPC分类号： A01N43/82 ,  A01N43/10 ,  A01N43/647 ,  A61L2/084 ,  A61L2/16 ,  C07D409/14 ,  C07D417/14

摘要： Thiophene containing water-soluble oligomers were synthesized and characterized. The photophysical properties of these compounds were studied; transient absorption spectroscopy was used to probe the triplet excited state and their ability to sensitize singlet oxygen was spectroscopically monitored in deuterated methanol. The above compounds were tested for their light activated biocidal properties against S. aureus both under UV and visible radiation. Among the oligomers studied, the terthiophene derivative was found to kill the bacteria efficiently.

摘要翻译： 合成含有噻吩的水溶性低聚物并进行表征。 研究了这些化合物的光物理性质; 瞬态吸收光谱法用于探测三重激发态，并且在氘代甲醇中光谱监测其对单线态氧敏化的能力。 在UV和可见光辐射下，测试了上述化合物对金黄色葡萄球菌的光活化杀生物性质。 在研究的低聚物中，发现三噻吩衍生物有效杀死细菌。

公开(公告)号：US20160222150A1

公开(公告)日：2016-08-04

申请号：US15018179

申请日：2016-02-08

申请人： David G. Whitten ,  Harry Craig Pappas ,  Eric H Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

发明人： David G. Whitten ,  Harry Craig Pappas ,  Eric H Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

IPC分类号： C08F238/00 ,  A61L15/44 ,  A01N43/50 ,  A61L15/24

CPC分类号： A01N43/50 ,  A01N33/08 ,  A01N33/12 ,  A01N43/90 ,  A61L15/24 ,  A61L15/46 ,  A61L2300/404 ,  A61L2420/02 ,  C07D233/64 ,  C07D409/06

摘要： Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.

摘要翻译： 所公开的各种实施方案涉及共轭聚电解质及其使用方法。 各种实施方案提供包含具有结构-R1-Y-R2-Z-的亚单位的共轭聚电解质。 在每次出现时，R 1独立地选自被-X-R 3 -R 4取代的1,4-键合的亚苯基，并且被-X-R 3 -R 4取代的2,5-键合的噻吩j次。 在每次出现时，Y独立地选自键和-C≡C-。 在每次出现时，R 2独立地选自键，取代或未取代的亚苯基，亚噻吩基，薁基，亚萘基，亚联苯基，亚茚基，亚芴基，亚菲基，亚苯基亚苯基，亚芘基，亚萘基，亚磺酰基，亚联苯基，蒽基和亚萘基。 在每次出现时，Z独立地选自键和-C≡C-。 变量j，R3和R4如本文所定义。

公开(公告)号：US09750250B2

公开(公告)日：2017-09-05

申请号：US15018179

申请日：2016-02-08

申请人： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

发明人： David G. Whitten ,  Harry Craig Pappas ,  Eric H. Hill ,  Kirk S. Schanze ,  Anand Parthasarathy ,  Yun Huang ,  Thomas S. Corbitt

IPC分类号： C08F238/00 ,  A61L15/44 ,  A01N43/50 ,  A61L15/24 ,  A61L15/46 ,  A01N33/08 ,  A01N33/12 ,  A01N43/90

CPC分类号： A01N43/50 ,  A01N33/08 ,  A01N33/12 ,  A01N43/90 ,  A61L15/24 ,  A61L15/46 ,  A61L2300/404 ,  A61L2420/02 ,  C07D233/64 ,  C07D409/06

摘要： Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.

公开(公告)号：US20130330386A1

公开(公告)日：2013-12-12

申请号：US13993026

申请日：2011-12-12

申请人： David G. Whitten ,  Kirk Schanze ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

发明人： David G. Whitten ,  Kirk Schanze ,  Eunkyung Ji ,  Thomas S. Corbitt ,  Dimitri Dascier

IPC分类号： A01N41/04

CPC分类号： A01N41/04 ,  A01N33/12 ,  C08F230/08 ,  A01N25/10 ,  A01N37/38

摘要： The present disclosure provides novel polyampholyte compounds, methods for synthesizing these compounds, and materials and substances incorporating these compounds. The various polyampholytes show antibacterial activity and may also demonstrate antiviral antifungal and/or antibiofilm activity.

摘要翻译： 本公开提供了新的聚阴离子化合物，合成这些化合物的方法，以及掺入这些化合物的材料和物质。 各种多聚电解质显示抗菌活性，并且还可以显示抗病毒抗真菌和/或抗菌膜活性。