-
公开(公告)号:US09750250B2
公开(公告)日:2017-09-05
申请号:US15018179
申请日:2016-02-08
申请人: David G. Whitten , Harry Craig Pappas , Eric H. Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
发明人: David G. Whitten , Harry Craig Pappas , Eric H. Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
IPC分类号: C08F238/00 , A61L15/44 , A01N43/50 , A61L15/24 , A61L15/46 , A01N33/08 , A01N33/12 , A01N43/90
CPC分类号: A01N43/50 , A01N33/08 , A01N33/12 , A01N43/90 , A61L15/24 , A61L15/46 , A61L2300/404 , A61L2420/02 , C07D233/64 , C07D409/06
摘要: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.
-
公开(公告)号:US20160222150A1
公开(公告)日:2016-08-04
申请号:US15018179
申请日:2016-02-08
申请人: David G. Whitten , Harry Craig Pappas , Eric H Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
发明人: David G. Whitten , Harry Craig Pappas , Eric H Hill , Kirk S. Schanze , Anand Parthasarathy , Yun Huang , Thomas S. Corbitt
IPC分类号: C08F238/00 , A61L15/44 , A01N43/50 , A61L15/24
CPC分类号: A01N43/50 , A01N33/08 , A01N33/12 , A01N43/90 , A61L15/24 , A61L15/46 , A61L2300/404 , A61L2420/02 , C07D233/64 , C07D409/06
摘要: Various embodiments disclosed relate to conjugated polyelectrolytes and methods of using the same. Various embodiments provide a conjugated polyelectrolyte including a subunit having the structure —R1—Y—R2—Z—. At each occurrence, R1 is independently chosen from 1,4-bonded phenylene substituted by —X—R3—R4 j times and 2,5-bonded thiophene substituted by —X—R3—R4 j times. At each occurrence, Y is independently chosen from a bond and —C≡C—. At each occurrence, R2 is independently chosen from a bond, a substituted or unsubstituted phenylene, thiophenylene, azulenylene, heptalenylene, biphenylene, indacenylene, fluorenylene, phenanthrenylene, triphenylenylene, pyrenylene, naphthacenylene, chrysenylene, biphenylenylene, anthracenylene, and naphthylene. At each occurrence, Z is independently chosen from a bond and —C≡C—. The variables j, R3, and R4 are as defined herein.
摘要翻译: 所公开的各种实施方案涉及共轭聚电解质及其使用方法。 各种实施方案提供包含具有结构-R1-Y-R2-Z-的亚单位的共轭聚电解质。 在每次出现时,R 1独立地选自被-X-R 3 -R 4取代的1,4-键合的亚苯基,并且被-X-R 3 -R 4取代的2,5-键合的噻吩j次。 在每次出现时,Y独立地选自键和-C≡C-。 在每次出现时,R 2独立地选自键,取代或未取代的亚苯基,亚噻吩基,薁基,亚萘基,亚联苯基,亚茚基,亚芴基,亚菲基,亚苯基亚苯基,亚芘基,亚萘基,亚磺酰基,亚联苯基,蒽基和亚萘基。 在每次出现时,Z独立地选自键和-C≡C-。 变量j,R3和R4如本文所定义。
-
公开(公告)号:US10772851B2
公开(公告)日:2020-09-15
申请号:US15886469
申请日:2018-02-01
申请人: Aaron Kurt Neumann , Harry Craig Pappas , Matthew Graus , David G. Whitten , Kirk S. Schanze , Rina Sylejmani
发明人: Aaron Kurt Neumann , Harry Craig Pappas , Matthew Graus , David G. Whitten , Kirk S. Schanze , Rina Sylejmani
IPC分类号: A61K31/14 , A61K31/75 , A61K31/795 , A61P31/10
摘要: Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a β-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the β-glucan to increase immunogenicity of the fungus.
-
公开(公告)号:US20180221309A1
公开(公告)日:2018-08-09
申请号:US15886469
申请日:2018-02-01
IPC分类号: A61K31/14 , A61K31/75 , A61K31/795 , A61P31/10
CPC分类号: A61K31/14 , A61K31/75 , A61K31/795 , A61P31/10
摘要: Various embodiments disclosed relate to treatment of fungal infections. The present invention provides a method of treating a fungal infection including contacting a fungus including a β-glucan that is at least partially masked from immune system detection with a therapeutically effective amount of a compound that at least partially unmasks the β-glucan to increase immunogenicity of the fungus.
-
-
-