公开(公告)号：US20070155781A1

公开(公告)日：2007-07-05

申请号：US11604677

申请日：2006-11-28

申请人： David Garvey ,  L. Letts ,  H. Renfroe ,  Stewart Richardson

发明人： David Garvey ,  L. Letts ,  H. Renfroe ,  Stewart Richardson

IPC分类号： A61K31/46 ,  C07D451/02

CPC分类号： C07D451/06 ,  C07C313/36 ,  C07D311/22 ,  C07D451/10 ,  C07D471/04 ,  C07J5/00 ,  C07J7/00 ,  C07J31/00 ,  C07J71/00 ,  C07J71/0031

摘要： Disclosed are (i) compounds of a steroid, a β-agonist, an anticholinergic, a mast cell stabilizer and a phosphodiesterase (PDE) inhibitor directly or indirectly linked to a NO or NO2 group or a group which stimulates endogenous production of NO or EDRF in vivo; (ii) compositions of steroids, β-agonists, anticholinergics, mast cell stabilizers and PDE inhibitors, which can optionally be substituted with at least one NO or NO2 moiety or a group which stimulates endogenous production of NO or EDRF in vivo, and a compound that donates, transfers or releases nitric oxide as a charged species, i.e., nitrosonium (NO+) or nitroxyl (NO−), or as the neutral species, nitric oxide (NO.) or that stimulates endogenous production of NO or EDRF in vivo; and (iii) uses for them in preventing and/or treating respiratory disorders.

摘要翻译： 公开的是（i）直接或间接连接到NO或NO 2基团或基团上的基团的类固醇，β-激动剂，抗胆碱能药，肥大细胞稳定剂和磷酸二酯酶（PDE）抑制剂的化合物 其在体内刺激NO或EDRF的内源性产生; （ii）类固醇，β-激动剂，抗胆碱能药物，肥大细胞稳定剂和PDE抑制剂的组合物，其可任选地被至少一个NO或NO 2个部分取代，或刺激内源性产生NO 或EDRF，以及作为带电物质，即亚硝酸盐（硝酸）或硝酰基（NO +）的一氧化氮，或NOX + 作为中性物种，一氧化氮（NO））或者在体内刺激NO或EDRF的内源性产生; 和（iii）用于预防和/或治疗呼吸系统疾病。

公开(公告)号：US20070179195A1

公开(公告)日：2007-08-02

申请号：US11730886

申请日：2007-04-04

申请人： L. Letts ,  David Garvey

发明人： L. Letts ,  David Garvey

IPC分类号： A61K31/21 ,  C07C229/38

CPC分类号： C07D295/185 ,  A61K45/06 ,  C07C229/42 ,  C07C317/18 ,  C07C323/12 ,  C07D493/04

摘要： The invention provides novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitors and novel compositions and kits comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) selective inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or, optionally, at least one therapeutic agent. The invention also provides methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 selective inhibitors; for facilitating wound healing; for treating and/or preventing renal and/or respiratory toxicity; for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2; and for improving the cardiovascular profile of COX-2 selective inhibitors.

摘要翻译： 本发明提供新的亚硝化和/或亚硝基化的环氧合酶2（COX-2）选择性抑制剂和包含至少一种亚硝化和/或亚硝基化的环氧合酶2（COX-2）选择性抑制剂的新组合物和试剂盒，以及任选的至少一种化合物 捐赠，转移或释放一氧化氮，刺激一氧化氮的内源性合成，提高内源性内皮水平的内源性松弛因子，或者是一氧化氮合酶的底物和/或任选的至少一种治疗剂。 本发明还提供了治疗炎症，疼痛和发烧的方法; 用于治疗和/或改善COX-2选择性抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾和/或呼吸毒性; 用于治疗和/或预防由环氧合酶-2水平升高引起的其他疾病; 并用于改善COX-2选择性抑制剂的心血管外形。

公开(公告)号：US20060276439A1

公开(公告)日：2006-12-07

申请号：US11505905

申请日：2006-08-18

申请人： David Garvey ,  L. Letts ,  H. Renfroe ,  Sang Tam

发明人： David Garvey ,  L. Letts ,  H. Renfroe ,  Sang Tam

IPC分类号： A61K31/60 ,  A61K31/343

CPC分类号： C07D417/12 ,  A61K31/343 ,  A61K31/60 ,  A61K38/00 ,  C07C203/00 ,  C07C327/28 ,  C07C381/00 ,  C07D209/28 ,  C07J41/0055 ,  C07K5/0215 ,  A61K2300/00

摘要： Nonsteroidal antiinflammatory drugs which have been substituted with a nitrogen monoxide group; compositions comprising (i) a nonsteroidal antiinflammatory drug, which can optionally be substituted with a nitrogen monoxide group and (ii) a compound that directly donates, transfers or releases a nitrogen monoxide group (preferably as a charged species, particularly nitrosonium); and methods of treatment of inflammation, pain, gastrointestinal lesions and/or fever using the compositions are disclosed. The compounds and compositions protect against the gastrointestinal, renal and other toxicities that are otherwise induced by nonsteroidal antiinflammatory drugs.

公开(公告)号：US20070238740A1

公开(公告)日：2007-10-11

申请号：US10568819

申请日：2004-08-20

申请人： David Garvey ,  L. Letts ,  Manuel Worcel

发明人： David Garvey ,  L. Letts ,  Manuel Worcel

IPC分类号： A61K31/41 ,  A61K31/4164 ,  A61K31/4184 ,  A61K31/4439 ,  A61K31/444 ,  A61K31/506 ,  A61K31/519 ,  C07D233/42 ,  C07D233/54 ,  C07D239/22 ,  C07D257/04 ,  C07D401/10 ,  C07D403/10 ,  C07D471/04 ,  C07D487/04

CPC分类号： C07D403/10 ,  C07C205/40 ,  C07D233/68 ,  C07D235/18 ,  C07D257/04 ,  C07D307/52 ,  C07D401/12 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/04 ,  C07D409/06 ,  C07D409/14 ,  C07D413/10 ,  C07D471/04 ,  C07D487/04 ,  C07D495/04 ,  C07D498/04

摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated aldosterone antagonists, nitrosated and/or nitrosylated angiotensin II antagonists, nitrosated and/or nitrosylated calcium channel blockers, nitrosated and/or nitrosylated endothelin antagonists, nitrosated and/or nitrosylated hydralazine compounds, nitrosated and/or nitrosylated neutral endopeptidase inhibitors and nitrosated and/or nitrosylated renin inhibitors.

摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物 。 本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。 本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。 亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝基化的醛固酮拮抗剂，亚硝化和/或亚硝酰化的血管紧张素II拮抗剂，亚硝化和/或亚硝酰化的钙通道阻断剂，亚硝化和/或亚硝基化的内皮素拮抗剂，亚硝化和/ 化合物，亚硝化和/或亚硝基化的中性内肽酶抑制剂和亚硝化和/或亚硝基化的肾素抑制剂。

公开(公告)号：US20070112067A1

公开(公告)日：2007-05-17

申请号：US11641050

申请日：2006-12-19

申请人： David Garvey ,  Ricky Gaston ,  L. Letts ,  Inigo de Tejada ,  Sang Tam ,  Manuel Worcel

发明人： David Garvey ,  Ricky Gaston ,  L. Letts ,  Inigo de Tejada ,  Sang Tam ,  Manuel Worcel

IPC分类号： A61K31/21 ,  C07C203/02

CPC分类号： A61K31/5575

摘要： The invention describes novel nitrosated and/or nitrosylated prostaglandins, and novel compositions comprising at least one nitrosated and/or nitrosylated prostaglandin, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase, and/or at least one vasoactive agent. The invention also provides novel compositions comprising at least one prostaglandin and at least one S-nitrosothiol compound, and, optionally, at least one vasoactive agent. The prostaglandin is preferably a prostaglandin E1 compound, more preferably alprostadil, and the S-nitrosothiol compound is preferably S-nitrosoglutathione. The invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing cerebrovascular disorders, cardiovascular disorders, benign prostatic hyperplasia (BPH), glaucoma, peptic ulcers or for inducing abortions.

摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的前列腺素，以及包含至少一种亚硝化和/或亚硝基化的前列腺素的新组合物，以及任选的至少一种捐赠，转移或释放一氧化氮的化合物，提高内源性内皮水平的放松 因子，刺激一氧化氮的内源性合成或是一氧化氮合酶的底物和/或至少一种血管活性剂。 本发明还提供了包含至少一种前列腺素和至少一种S-亚硝基硫醇化合物和任选的至少一种血管活性剂的新型组合物。 前列腺素优选为前列腺素E 1化合物，更优选前列地尔，S-亚硝基硫醇化合物优选为S-亚硝基谷胱甘肽。 本发明还提供用于治疗或预防男性和女性的性功能障碍的方法，用于增强男性和女性的性反应，以及用于治疗或预防脑血管疾病，心血管疾病，良性前列腺增生（BPH），青光眼，消化性溃疡或诱导 堕胎

公开(公告)号：US20070060571A1

公开(公告)日：2007-03-15

申请号：US11599519

申请日：2006-11-15

申请人： Ramani Bandarage ,  Upul Bandarage ,  Xinqin Fang ,  David Garvey ,  L. Letts ,  Joseph Schroeder ,  Sang Tam

发明人： Ramani Bandarage ,  Upul Bandarage ,  Xinqin Fang ,  David Garvey ,  L. Letts ,  Joseph Schroeder ,  Sang Tam

IPC分类号： A61K31/55 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/454 ,  C07D417/02 ,  C07D413/02 ,  C07D403/02

CPC分类号： C07D207/333 ,  C07C317/46 ,  C07C381/00 ,  C07D209/12 ,  C07D209/18 ,  C07D231/12 ,  C07D231/14 ,  C07D233/64 ,  C07D237/14 ,  C07D261/08 ,  C07D263/20 ,  C07D307/58 ,  C07D311/12 ,  C07D413/12 ,  C07D471/04

摘要： The present invention describes novel nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitors and novel compositions comprising at least one nitrosated and/or nitrosylated cyclooxygenase 2 (COX-2) inhibitor, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or optionally, at least one therapeutic agent. The present invention also provides novel compositions comprising at least one parent COX-2 inhibitor and at least one nitric oxide donor, and, optionally, at least one therapeutic agent. The present invention also provides kits and methods for treating inflammation, pain and fever; for treating and/or improving the gastrointestinal properties of COX-2 inhibitors; for facilitating wound healing; for treating and/or preventing renal toxicity; and for treating and/or preventing other disorders resulting from elevated levels of cyclooxygenase-2.

摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂和包含至少一种亚硝化和/或亚硝基化的环氧合酶2（COX-2）抑制剂的新组合物，和任选的至少一种可以提供， 转移或释放一氧化氮，刺激一氧化氮的内源性合成，提高内皮衍生的松弛因子的内源水平，或者是一氧化氮合酶的底物和/或任选的至少一种治疗剂。 本发明还提供了包含至少一种母体COX-2抑制剂和至少一种一氧化氮供体以及任选的至少一种治疗剂的新型组合物。 本发明还提供用于治疗炎症，疼痛和发烧的试剂盒和方法; 用于治疗和/或改善COX-2抑制剂的胃肠性质; 促进伤口愈合; 用于治疗和/或预防肾毒性; 并且用于治疗和/或预防由环氧合酶-2水平升高引起的其它疾病。

公开(公告)号：US20070010571A1

公开(公告)日：2007-01-11

申请号：US10569077

申请日：2004-08-20

申请人： David Garvey ,  L. Letts ,  Manuel Worcel ,  Ricky Gaston

发明人： David Garvey ,  L. Letts ,  Manuel Worcel ,  Ricky Gaston

IPC分类号： A61K31/405 ,  A61K31/138 ,  C07D209/20

CPC分类号： C07D493/04 ,  C07D407/04 ,  C07K5/06026

摘要： The invention describes novel nitrosated and/or nitrosylated cardiovascular compounds or pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated cardiovascular compound, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides novel compositions and kits comprising at,least one cardiovascular compound of the invention, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor compound and/or at least one therapeutic agent. The invention also provides methods for (a) treating cardiovascular diseases; (b) treating renovascular diseases; (c) treating diabetes; (d) treating diseases resulting from oxidative stress; (e) treating endothelial dysfunctions; (f) treating diseases caused by endothelial dysfunctions; (g) treating cirrhosis; (h) treating pre-eclampsia; (j) treating osteoporosis; and (k) treating nephropathy. The nitrosated and/or nitrosylated cardiovascular compounds are preferably nitrosated and/or nitrosylated P-adrenergic antagonists, nitrosated and/or nitrosylated angiotensinconverting enzyme (ACE) inhibitors, nitrosated and/or nitrosylated anti-hyperlipidemic compounds, and nitrosated and/or nitrosylated antithrombotic and vasodilator compounds.

摘要翻译： 本发明描述了新的亚硝化和/或亚硝基化的心血管化合物或其药学上可接受的盐，以及包含至少一种亚硝化和/或亚硝基化的心血管化合物和任选的至少一种一氧化氮供体和/或至少一种治疗剂的新组合物 。 本发明还提供了包含至少一种本发明的心血管化合物，其任选被亚硝化和/或亚硝基化的新组合物和试剂盒，以及任选的至少一种一氧化氮供体化合物和/或至少一种治疗剂。 本发明还提供了（a）治疗心血管疾病的方法; （b）治疗血管性疾病; （c）治疗糖尿病; （d）治疗由氧化应激引起的疾病; （e）治疗内皮功能障碍; （f）治疗由内皮功能障碍引起的疾病; （g）治疗肝硬化; （h）治疗先兆子痫; （j）治疗骨质疏松症; 和（k）治疗肾病。 亚硝化和/或亚硝基化的心血管化合物优选为亚硝化和/或亚硝化的P-肾上腺素能拮抗剂，亚硝化和/或亚硝化的血管紧张素转换酶（ACE）抑制剂，亚硝化和/或亚硝化的抗高脂血症化合物，以及亚硝化和/或亚硝化的抗血栓形成和/ 血管扩张剂化合物。

公开(公告)号：US20060075002A1

公开(公告)日：2006-04-06

申请号：US10531260

申请日：2003-10-14

申请人： James Tarbell ,  David Garvey

发明人： James Tarbell ,  David Garvey

IPC分类号： G06F17/30

CPC分类号： G06F11/1415 ,  G06F11/1471 ,  G06F11/2071 ,  G06F2201/855

摘要： A method of journaling changes to system objects. A dummy function is substituted for a system function. The system function is executed under operation of the dummy function. Copies of system objects changed by execution of the system function are generated for journaling. Execution of the dummy function is then completed. Preferably the system objects are OS/400 system objects. The system objects may be program objects, configuration objects, queues and space/memory mapped objects. The copies of the system objects may be journaled for replication on another system. A system and software for journaling changes to system objects are also disclosed.

摘要翻译： 将更改记录到系统对象的方法。 虚拟函数代替系统函数。 系统功能在虚拟功能的运行下执行。 生成用于日记功能执行系统功能的系统对象副本。 然后完成虚拟函数的执行。 系统对象最好是OS / 400系统对象。 系统对象可以是程序对象，配置对象，队列和空间/内存映射对象。 可以将系统对象的副本记录在另一个系统上进行复制。 还公开了用于日志更改系统对象的系统和软件。

公开(公告)号：US5522310A

公开(公告)日：1996-06-04

申请号：US375191

申请日：1995-01-18

申请人： Gary W. Black, Sr. ,  David Garvey

发明人： Gary W. Black, Sr. ,  David Garvey

IPC分类号： A47J27/14 ,  G07F9/10 ,  G07F11/00

CPC分类号： H05B6/808 ,  A47J27/14 ,  G07F17/0078 ,  G07F9/105

摘要： A completely automatic, fully self-contained vending machine of standard size which may be operated so that a packaged (boxed) dough-based food product such as a pizza can be withdrawn from a freezer for storing the food product, and delivered to a microwave oven for heating to an appropriate temperature, for delivery (of the heated and cooked food product) to the consumer within a relative short, commercially-desirable time period on the order of one minute or less. Also, a special, high intensity microwave oven which incorporates directionally variable guide vanes for regulating the microwave cooking process with improved efficiency; a dough-based food product (such as a pizza or the like) constituted of a dough which is specially blended for interacting with the microwave oven to achieve rapid cooking times while simultaneously providing a cooked food product of improved taste, quality and consistency; and a carton for containing the food product which is formed in a manner which facilitates all phases of the food-dispensing process including freezing, microwave cooking, and eventual delivery to the consumer.

摘要翻译： 一种完全自动的，完全独立的标准尺寸的自动售货机，其可以被操作，使得可以从用于储存食品的冷冻机中取出包装（盒装的）面团型食品如比萨饼，并送到微波炉 加热至适当温度的烘箱，用于在相当短的，商业上期望的时间段内（约1分钟或更短）的时间将（加热和熟化的食品）输送到消费者。 另外，一种特殊的高强度微波炉，其结合了可变导向叶片，用于调节微波烹饪过程，提高了效率; 由面团制成的面团型食品（比如比萨饼等），该面团特意混合，与微波炉相互作用以实现快速的烹饪时间，同时提供具有改善口感，品质和一致性的熟食品; 以及用于容纳食品的纸箱，其以促进食物分配过程的所有阶段的方式形成，包括冷冻，微波烹饪和最终输送到消费者。

公开(公告)号：US20060063774A1

公开(公告)日：2006-03-23

申请号：US10943982

申请日：2004-09-20

申请人： David Garvey ,  Inigo Tejada

发明人： David Garvey ,  Inigo Tejada

IPC分类号： A61K31/54 ,  A61K31/519 ,  A61K31/50 ,  A61K31/44 ,  A61K31/4015

CPC分类号： A61K31/4015 ,  A61K31/44 ,  A61K31/50 ,  A61K31/519 ,  A61K31/54

摘要： The invention provides phosphodiesterase inhibitors and/or nitric oxide donors that are useful in treating male impotence, female sexual dysfunction and anal diseases.

摘要翻译： 本发明提供了可用于治疗男性阳ence，女性性功能障碍和肛门疾病的磷酸二酯酶抑制剂和/或一氧化氮供体。