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公开(公告)号：US06550590B1
公开(公告)日：2003-04-22
申请号：US10079224
申请日：2002-02-20
申请人： Srikanth Ranganathan
发明人： Srikanth Ranganathan
IPC分类号： F16D6510
CPC分类号： F16D65/12 , F16D2065/1328
摘要： A brake rotor has double annular vents with cooling vanes connecting inboard and outboard cheeks of a rotor to a central support ring. Each of the annular vents provides separate passages for cooling the adjacent cheek of the brake rotor and separate inlets are provided for the dual vents from opposite sides of the central support ring. Aligned and staggered vane embodiments and parallel and angled passage embodiments are disclosed. The dual vents increase both the flow rate and the surface area for heat transmission and flow the air closer to the heated cheek surfaces. The staggered vanes improve stiffness and the slanted passages have potential stiffness and heat sink advantages.
摘要翻译： 制动转子具有双环形通风口，其中冷却叶片将转子的内侧和外侧两面连接到中心支撑环。 每个环形通风口提供用于冷却制动转子的相邻颊部的单独的通道，并且为中心支撑环的相对侧的双通气口提供单独的入口。 公开了对准和交错的叶片实施例和平行和倾斜的通道实施例。 双通道增加了传热的流速和表面积，并使空气更接近加热的脸颊表面。 交错的叶片改善了刚度，倾斜通道具有潜在的刚度和散热器的优点。
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公开(公告)号：US08202510B2
公开(公告)日：2012-06-19
申请号：US12957686
申请日：2010-12-01
IPC分类号： A61K49/00 , G01N33/00 , G01N33/48 , G01N33/566 , C40B20/08
CPC分类号： G01N33/6848 , G01N33/6896 , G01N2800/2835 , G01N2800/285 , Y10T436/143333 , Y10T436/24
摘要： The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.
摘要翻译： 本发明提供了一种用于诊断受试者的肌萎缩性侧索硬化（ALS）的方法，用于评估药物治疗ALS的有效性的方法以及用于确定受试者中ALS发作位点的方法。 每种方法包括（a）从受试者获得样品，（b）通过质谱分析样品中的蛋白质，和（c）确定样品的质谱图。 在一些实施方案中，该方法包括将样品的质谱图与正或负标准的质谱图进行比较。
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13.发明申请Method and system for modeling valve dynamic behavior using computational fluid dynamics 审中-公开使用计算流体动力学建模阀动态特性的方法和系统公开(公告)号：US20060230840A1
公开(公告)日：2006-10-19
申请号：US11240476
申请日：2005-10-03
申请人： Srikanth Ranganathan
发明人： Srikanth Ranganathan
IPC分类号： G01F1/00
CPC分类号： F16K11/07
摘要： A system for modeling fluid flow in a valve (10) includes a section for modeling a main fluid flow domain having an inlet (25), a first outlet (26) and a second outlet using a first grid size, a section for modeling a leakage fluid flow domain (38) having an inlet that includes the main fluid flow domain second outlet and a leakage fluid flow outlet using a second grid size, and a section for iteratively calculating fluid flow in the main fluid flow domain based on leakage flow as determined by the section for modeling leakage fluid flow. Also a method for modeling fluid flow in a valve.
摘要翻译： 用于对阀（10）中的流体流动进行建模的系统包括用于对具有入口（25），第一出口（26）和使用第一格栅尺寸的第二出口的主流体流域进行建模的部分， 具有包括主流体流域第二出口的入口和使用第二格栅尺寸的泄漏流体流出口的泄漏流体流动区域（38），以及用于基于泄漏流量迭代地计算主流体流动域中的流体流动的部分 由泄漏流体流动建模部分确定。 也是一种用于建模阀中流体流动的建模方法。
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公开(公告)号：US20050148026A1
公开(公告)日：2005-07-07
申请号：US10972732
申请日：2004-10-25
IPC分类号： C12Q20060101 , G01N33/00 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6848 , G01N33/6896 , G01N2800/2835 , G01N2800/285 , Y10T436/143333 , Y10T436/24
摘要： The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.
摘要翻译： 本发明提供了一种用于诊断受试者的肌萎缩性侧索硬化（ALS）的方法，用于评估药物治疗ALS的有效性的方法以及用于确定受试者中ALS发作位点的方法。 每种方法包括（a）从受试者获得样品，（b）通过质谱分析样品中的蛋白质，和（c）确定样品的质谱图。 在一些实施方案中，该方法包括将样品的质谱图与正或负标准的质谱图进行比较。
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公开(公告)号：US20110104739A1
公开(公告)日：2011-05-05
申请号：US12957686
申请日：2010-12-01
CPC分类号： G01N33/6848 , G01N33/6896 , G01N2800/2835 , G01N2800/285 , Y10T436/143333 , Y10T436/24
摘要： The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.
摘要翻译： 本发明提供了一种用于诊断受试者的肌萎缩性侧索硬化（ALS）的方法，用于评估药物治疗ALS的有效性的方法以及用于确定受试者中ALS发作位点的方法。 每种方法包括（a）从受试者获得样品，（b）通过质谱分析样品中的蛋白质，和（c）确定样品的质谱图。 在一些实施方案中，该方法包括将样品的质谱图与正或负标准的质谱图进行比较。
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公开(公告)号：US07858071B2
公开(公告)日：2010-12-28
申请号：US10972732
申请日：2004-10-25
CPC分类号： G01N33/6848 , G01N33/6896 , G01N2800/2835 , G01N2800/285 , Y10T436/143333 , Y10T436/24
摘要： The invention provides a method for diagnosing amyotrophic lateral sclerosis (ALS) in a subject, a method for assessing the effectiveness of a drug in treating ALS, and a method for determining the site of onset of ALS in a subject. Each method comprises (a) obtaining a sample from the subject, (b) analyzing the proteins in the sample by mass spectroscopy, and (c) determining a mass spectral profile for the sample. In some embodiments, the method comprises comparing the mass spectral profile of the sample to the mass spectral profile of a positive or a negative standard.
摘要翻译： 本发明提供了一种用于诊断受试者的肌萎缩性侧索硬化（ALS）的方法，用于评估药物治疗ALS的有效性的方法以及用于确定受试者中ALS发作位点的方法。 每种方法包括（a）从受试者获得样品，（b）通过质谱分析样品中的蛋白质，和（c）确定样品的质谱图。 在一些实施方案中，该方法包括将样品的质谱图与正或负标准的质谱图进行比较。
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公开(公告)号：US20090007570A1
公开(公告)日：2009-01-08
申请号：US11774179
申请日：2007-07-06
申请人： Srikanth Ranganathan
发明人： Srikanth Ranganathan
CPC分类号： F01D25/125 , F02C7/14 , F05D2220/36 , F05D2250/71 , F05D2260/205 , F05D2260/213 , F05D2260/22141 , F05D2260/232 , F05D2260/98 , F28D9/00 , F28D2021/0021 , F28F13/08 , Y02T50/675 , Y10T29/4932
摘要： A method of assembling a turbine engine is provided. The method includes providing a heat exchanger having a curvilinear body. The method also includes coupling the heat exchanger to at least one of a fan casing and an engine casing of the turbine engine. The curvilinear body facilitates reducing pressure losses in airflow channeled into the heat exchanger.
摘要翻译： 提供一种组装涡轮发动机的方法。 该方法包括提供具有曲线体的热交换器。 该方法还包括将热交换器耦合到涡轮发动机的风扇壳体和发动机壳体中的至少一个。 曲线体有助于减少通向热交换器的气流中的压力损失。
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