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公开(公告)号:US09089626B2
公开(公告)日:2015-07-28
申请号:US12762796
申请日:2010-04-19
申请人: Mark W. Bleyer , Michael C. Hiles , Umesh H. Patel
发明人: Mark W. Bleyer , Michael C. Hiles , Umesh H. Patel
IPC分类号: A61K9/06 , A01N59/00 , A61F2/06 , A61L27/36 , A61K35/38 , A61L27/24 , A61L27/50 , A61L29/00 , A61L31/00 , A61B19/00
CPC分类号: A61L27/3683 , A61B90/39 , A61K35/38 , A61L27/24 , A61L27/3604 , A61L27/50 , A61L29/005 , A61L31/005
摘要: Disclosed is a medical device (5) and more particularly, an implantable biomaterial. The biomaterial comprises a radiopaque (22) collagenous biomaterial (10).
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公开(公告)号:US07857825B2
公开(公告)日:2010-12-28
申请号:US10718155
申请日:2003-11-20
CPC分类号: A61K35/38 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12168 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B90/39 , A61L31/005 , A61L31/18 , A61L2430/36
摘要: A medical device (40) including a collagenous biomaterial (10) for causing embolus and treating an aneurysm. The collagenous biomaterial (10) includes a small intestine submucosa (12) that is configured into various components (16) for causing a vascular occlusion or a packing aneurysm lumen.
摘要翻译: 一种包括用于引起栓塞和治疗动脉瘤的胶原生物材料(10)的医疗装置(40)。 胶原生物材料(10)包括被配置成用于引起血管闭塞或包装动脉瘤腔的各种成分(16)的小肠粘膜下层(12)。
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公开(公告)号:US07713552B2
公开(公告)日:2010-05-11
申请号:US10025282
申请日:2001-12-19
申请人: Mark W. Bleyer , Michael C. Hiles , Umesh H. Patel
发明人: Mark W. Bleyer , Michael C. Hiles , Umesh H. Patel
CPC分类号: A61L27/3683 , A61B90/39 , A61K35/38 , A61L27/24 , A61L27/3604 , A61L27/50 , A61L29/005 , A61L31/005
摘要: Disclosed is a medical device (5) and more particularly, an implantable biomaterial. The biomaterial comprises a radiopaque (22) collagenous biomaterial (10).
摘要翻译: 公开了一种医疗装置(5),更具体地,涉及可植入生物材料。 生物材料包括不透射线(22)胶原生物材料(10)。
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公开(公告)号:US09956315B2
公开(公告)日:2018-05-01
申请号:US11414682
申请日:2006-04-28
CPC分类号: A61L27/3604 , A61B17/0057 , A61B2017/00641 , A61K35/22 , A61K35/38 , A61L31/005
摘要: Described are medical products, systems, and methods for treating fistulae having a primary opening, such as in the alimentary canal. Certain methods of the invention include providing an implantable material including a compliant sheet form biocompatible material, and forcing this sheet form biocompatible material into the primary opening so as to deform the sheet form biocompatible material to conform to and block the primary opening. The biocompatible material preferably comprises a remodelable material, for example, a remodelable extracellular matrix material such as submucosa.
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15.
公开(公告)号:US20110060362A1
公开(公告)日:2011-03-10
申请号:US12948177
申请日:2010-11-17
IPC分类号: A61B17/03
CPC分类号: A61B17/0057 , A61B2017/00004 , A61B2017/00641
摘要: Provided by certain aspects of the invention are methods for treating fistulae and various fistula graft assemblages useful in this regard. Illustratively, some inventive methods are useful in treating fistulae having at least a first fistula opening, a second fistula opening and a fistula tract extending therebetween. In one step, a first capping member is positioned over the first fistula opening such that a first pulling member, which extends from the first capping member, passes through the fistula tract. In another step, a second capping member is positioned over the second fistula opening such that a second pulling member, which extends from the second capping member, passes through the fistula tract. A first pulling force is applied to the first pulling member, and a second pulling force is applied to the second pulling member, for maintaining the first capping member over the first fistula opening and for maintaining the second capping member over the second fistula opening, respectively.
摘要翻译: 由本发明的某些方面提供的是用于治疗瘘管和各种瘘移植物组合物的方法。 说明性地,一些本发明的方法可用于治疗具有至少第一瘘开口,第二瘘开口和在其间延伸的瘘管道的瘘。 在一个步骤中,第一封盖构件定位在第一瘘开口上方,使得从第一封盖构件延伸的第一牵引构件穿过瘘管道。 在另一步骤中,第二封盖构件定位在第二瘘开口上方,使得从第二封盖构件延伸的第二牵引构件穿过瘘管道。 第一拉力被施加到第一牵引构件,并且第二拉力施加到第二牵引构件,用于将第一封盖构件保持在第一瘘开口上方并且用于将第二封盖构件分别保持在第二瘘开口上方 。
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公开(公告)号:US20110046576A1
公开(公告)日:2011-02-24
申请号:US12939636
申请日:2010-11-04
IPC分类号: A61M5/00
CPC分类号: A61F2/0059
摘要: Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
摘要翻译: 公开了组织增加装置,以及制造和使用它们的方法。 在某些实施例中,组织增强装置包括细长的组织穿透构件和一定量的可重塑材料,其中细长构件的至少一部分被插管,并且至少部分材料量被容纳在至少一部分内 的细长构件的插管部分。 细长组织穿透构件可以提供至少一个变形,其被构造成收缩在细长构件内容纳的可重塑材料的量的部分。 在替代实施例中,可植入生物材料上的柔性覆盖物提供保护并且允许将生物材料更容易地递送到组织道。
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公开(公告)号:US07905826B2
公开(公告)日:2011-03-15
申请号:US11295866
申请日:2005-12-07
CPC分类号: A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要: This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译: 本发明在一个方面涉及用生物材料治疗血管血管。 生物材料可以是加强和/或支持血管壁的可重塑材料。 另外,生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。
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公开(公告)号:US08439942B2
公开(公告)日:2013-05-14
申请号:US12959799
申请日:2010-12-03
CPC分类号: A61K35/38 , A61B17/12022 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12145 , A61B17/1215 , A61B17/12163 , A61B17/12168 , A61B17/12172 , A61B17/12181 , A61B17/1219 , A61B90/39 , A61L31/005 , A61L31/18 , A61L2430/36
摘要: A medical device (40) including a collagenous biomaterial (10) for causing embolus and treating an aneurysm. The collagenous biomaterial (10) includes a small intestine submucosa (12) that is configured into various components (16) for causing a vascular occlusion or a packing aneurysm lumen.
摘要翻译: 一种包括用于引起栓塞和治疗动脉瘤的胶原生物材料(10)的医疗装置(40)。 胶原生物材料(10)包括被配置成用于引起血管闭塞或包装动脉瘤腔的各种成分(16)的小肠粘膜下层(12)。
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公开(公告)号:US08049059B2
公开(公告)日:2011-11-01
申请号:US10493458
申请日:2002-10-25
申请人: Mark W. Bleyer , Umesh H. Patel
发明人: Mark W. Bleyer , Umesh H. Patel
CPC分类号: A61L27/3683 , A61F2/105 , A61L15/40 , A61L15/42 , A61L27/3604 , A61L27/3633 , A61L27/3666 , A61L27/50 , A61L27/60 , A61L31/005
摘要: A tissue graft product includes at least one collagen layer comprised of submucosa or renal capsule tissue having slits therein to provide a mesh pattern which in turn establishes a graft structure that is highly deformable. The slits and mesh pattern provide for improved characteristics when utilized as a tissue graft and in particular an external wound care. Preferred devices have multiple submucosa, renal capsule or other collagenous extracellular matrix layers, providing a substantial and lasting scaffold for tissue ingrowth during wound treatment.
摘要翻译: 组织移植产品包括至少一个由粘膜下层或肾胶囊组织组成的胶原层,其中具有狭缝,以提供网状图案,其又形成高度可变形的移植结构。 当用作组织移植物并且特别是外部伤口护理时,狭缝和网格图案提供改进的特征。 优选的装置具有多个粘膜下层,肾胶囊或其他胶原细胞外基质层,为伤口治疗期间的组织向内生长提供了基本和持久的支架。
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公开(公告)号:US20110166673A1
公开(公告)日:2011-07-07
申请号:US12965205
申请日:2010-12-10
IPC分类号: A61F2/02
CPC分类号: A61L27/3633 , A61F2/0063 , A61F2/0077 , A61F2/02 , A61L27/3625 , A61L27/3629 , A61L27/50 , A61L31/005
摘要: Described are embodiments of a multilaminate or multiple layer implantable surgical graft with an illustrative graft comprising a remodelable collagenous sheet material, the graft including one or more interweaving members to stitch together the graft to help prevent the layers from delaminating or separating during handling and the initial stages of remodeling. The interweaving members may comprise lines of suture, thread, individual stitches, strips of material, etc. that are woven through the layers of biomaterial in a desired pattern. In one embodiment, the interweaving members comprise a pharmacologically active substance, such as a drug, growth factors, etc. to elicit a desired biological response in the host tissue. In another embodiment, the graft further comprises a reinforcing material, such as a synthetic mesh, within the layers of remodelable biomaterial and stitched together by one or more interweaving members.
摘要翻译: 描述了具有包含可重塑胶原片材料的说明性移植物的多层或多层可植入手术移植物的实施方案,所述移植物包括一个或多个交织构件以将移植物缝合在一起以帮助防止层在处理期间分层或分离,并且初始 重塑阶段。 交织构件可以包括以期望的图案编织穿过生物材料层的缝合线,线,单个线迹,材料条等。 在一个实施方案中,交织构件包含药理学活性物质,例如药物,生长因子等,以在宿主组织中引发所需的生物反应。 在另一个实施方案中,移植物还包括在可重塑生物材料层内的增强材料,例如合成网,并由一个或多个交织构件缝合在一起。
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