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公开(公告)号：US09538996B2
公开(公告)日：2017-01-10
申请号：US11669695
申请日：2007-01-31
CPC分类号： A61B17/0057 , A61B1/31 , A61B17/12159 , A61B17/3468 , A61B50/30 , A61B2017/00004 , A61B2017/00628 , A61B2017/00641 , A61B2017/00654 , A61B2017/00659 , A61B2017/00862 , A61B2017/00867 , A61B2017/22038 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3641 , A61L27/50
摘要： Described are medical graft products, systems, and methods for treating fistulae. Certain products of the invention are configured to have portions residing in and around a primary fistula opening, e.g., one occurring in a wall of the alimentary canal. One such product includes a biocompatible graft body which is configured to block at least the primary opening. The graft body includes a capping member, which is configured to contact portions of the alimentary canal wall adjacent to the primary opening, and an elongate plug member extending from the capping member, which is configured to extend into at least a portion of the fistula. In certain embodiments, a graft body component has the capacity to expand or otherwise change form to provide a suitable capping arrangement. Such a component can include a resilient wire frame, e.g., one that is self-expandable or one that requires at least some manipulation in order to expand.
摘要翻译： 描述了用于治疗瘘的医疗移植产品，系统和方法。 本发明的某些产品被配置为具有驻留在主瘘开口内和周围的部分，例如存在于消化道壁的一个。 一种这样的产品包括生物相容性移植物体，其构造成至少阻挡初级开口。 移植物主体包括封盖构件，其被构造成接触与初级开口相邻的消化道壁的部分，以及从封盖构件延伸的细长塞构件，其构造成延伸到至少一部分瘘。 在某些实施方案中，移植物体组分具有膨胀或以其它方式改变形式以提供合适的封盖装置的能力。 这样的部件可以包括弹性线框架，例如可自扩展的弹性线框架，或者需要至少一些操纵以便扩展的线框架。
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公开(公告)号：US09271817B2
公开(公告)日：2016-03-01
申请号：US12114456
申请日：2008-05-02
申请人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
发明人： Ryan Dempsey , Jeffrey Miller , Steve Chen , Umesh H. Patel , F. Joseph Obermiller , Bhavin Shah , Chad E. Johnson
CPC分类号： A61F2/0059 , A61B17/06004 , A61B2017/06052 , A61F2/02 , A61L27/24 , A61M5/32 , A61M25/0662 , A61M2025/018 , Y10S623/915
摘要： Tissue augmentation devices, as well as methods of manufacturing and using the same, are disclosed. In certain embodiments, a tissue augmentation device comprises an elongate tissue penetrating member and an amount of remodelable material, wherein at least a portion of the elongate member is cannulated, and at least a portion of the amount of material is received within at least a portion of the cannulated portion of the elongate member. The elongate tissue penetrating member may provide at least one deformation that is configured to constrict portions of the amount of remodelable material received within the elongate member. In alternate embodiments, a flexible covering over an implantable biomaterial provides protection and allows an easier delivery of the biomaterial to a tissue tract.
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3.发明授权公开(公告)号：US09226736B2
公开(公告)日：2016-01-05
申请号：US12793030
申请日：2010-06-03
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61M27/00
摘要： Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
摘要翻译： 描述了可用于治疗瘘的装置，方法和系统，并且在某些实施例中，具有延伸进入消化道的开口的那些，诸如肛门直肠瘘。 说明性地，可以通过将体积结构置于瘘的主要开口内来治疗肛门直肠瘘。 在某些实施方案中，体积构造可以包括经加工以形成基本上单体的卷状可重塑材料。 有益的这种可重塑材料可以包括胶原细胞外基质材料，如小肠粘膜下层。
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公开(公告)号：US20090012558A1
公开(公告)日：2009-01-08
申请号：US12166015
申请日：2008-07-01
申请人： Steve Chen , Jeremy Metz , F. Joseph Obermiller
发明人： Steve Chen , Jeremy Metz , F. Joseph Obermiller
CPC分类号： A61B17/0057 , A61B90/39 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61B2017/00893 , A61B2090/3983 , A61L27/3604 , A61L27/3641
摘要： This invention provides, in certain aspects, unique devices and methods for treating fistulae. In one embodiment, an inventive device includes an elongate graft body having a proximal end and a distal end. The graft body is configurable to a first condition and a second condition, the second condition including the distal end deflected laterally relative to its position in the first condition of the body. The device also includes a tether, which is connected to the graft body, and is configured to traverse proximally along the body. The tether is manipulable to convert the graft body from the first condition to the second condition. Such a device may also include one or more additional tethers connected to the graft body. For instance, a second tether can be configured to extend distally from the distal end of the graft body, and may be effective in pulling the graft body along a fistula tract.
摘要翻译： 本发明在某些方面提供用于治疗瘘的独特装置和方法。 在一个实施例中，本发明的装置包括具有近端和远端的细长移植体。 移植物主体可配置为第一状态和第二状态，所述第二状态包括远端在身体的第一状态中相对于其位置横向偏转的状态。 该装置还包括连接到移植物主体的系绳，并且构造成沿主体向近侧横越。 系绳可操作以将移植物体从第一状态转换到第二状态。 这种装置还可以包括连接到移植物主体的一个或多个附加系绳。 例如，第二系绳可以被构造成从移植物体的远端向远端延伸，并且可以有效地沿着瘘管拉动移植物体。
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公开(公告)号：US08663086B2
公开(公告)日：2014-03-04
申请号：US12892123
申请日：2010-09-28
IPC分类号： A61F2/02
CPC分类号： A61F2/0036 , A61B17/04 , A61B17/06
摘要： The embodiments described include graft devices for reinforcing patient tissue structures and methods of making and using the graft devices. In certain embodiments the graft devices have a remodelable extracellular matrix material graft body defining a slot and having a portion receivable through the slot to form a closed loop. Such graft devices can be used in encircling reinforcement of patient tissue structures such as anal sphincters or anastomosed vessel segments.
摘要翻译： 所描述的实施例包括用于加强患者组织结构的移植装置以及制造和使用移植装置的方法。 在某些实施方案中，移植装置具有限定狭缝的可重塑的细胞外基质材料移植物主体，并具有通过狭槽可接收部分以形成闭合环。 这种移植装置可以用于围绕加强患者组织结构，例如肛门括约肌或吻合血管段。
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公开(公告)号：US07905826B2
公开(公告)日：2011-03-15
申请号：US11295866
申请日：2005-12-07
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
摘要翻译： 本发明在一个方面涉及用生物材料治疗血管血管。 生物材料可以是加强和/或支持血管壁的可重塑材料。 另外，生物材料可以包括多种天然存在或添加的生物活性剂和/或活细胞群体。
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公开(公告)号：US07897167B2
公开(公告)日：2011-03-01
申请号：US11472642
申请日：2006-06-21
IPC分类号： A61F2/02
CPC分类号： A61B17/0057 , A61B17/0401 , A61B17/06 , A61B17/06166 , A61B17/3468 , A61B50/30 , A61B2017/00004 , A61B2017/00628 , A61B2017/00641 , A61B2017/00646 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/0404 , A61B2017/0464 , A61B2017/0496 , A61B2017/22038 , A61L27/227 , A61L27/24 , A61L27/3616 , A61L27/3629 , A61L27/3633 , A61L27/58 , A61M27/00
摘要： An implantable graft, which may be inserted into a fistula tract to occlude the primary opening of the fistula, is provided. To prevent unintentional displacement of the graft or extrusion of the graft from the fistula of a patient, the graft may be provided with a cap that extends laterally from at least one end of the body of the graft, where the cap may be integral with the body of the graft, attachable to at least one end of the body of the graft, and/or moveable along the body of the graft. The graft may also have a tail that extends from one end of the body of the graft to assist in placement of the graft in a fistula tract. The graft may be an integral unit made of a single material, such as a heterograft material, or may include distinct components made of the same or different materials. Methods for closing a fistula tract are also provided.
摘要翻译： 提供了一种植入式移植物，其可以插入瘘道以封闭瘘的主要开口。 为了防止移植物的意外移位或将移植物从患者的瘘管挤出，移植物可以设置有从移植物的主体的至少一端侧向延伸的帽，其中帽可以与 移植物的主体，可附接到移植物的身体的至少一端，和/或沿着移植物的主体移动。 移植物还可以具有从移植物的身体的一端延伸的尾部，以帮助将移植物放置在瘘管道中。 移植物可以是由诸如异种移植材料的单一材料制成的整体单元，或者可以包括由相同或不同材料制成的不同部件。 还提供了关闭瘘管的方法。
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8.发明授权公开(公告)号：US09572556B2
公开(公告)日：2017-02-21
申请号：US11415403
申请日：2006-05-01
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00641 , A61B2017/00654 , A61M27/00
摘要： Described are devices, methods, and systems useful in the treatment of fistulae, and in certain embodiments those having openings extending into the alimentary canal, such as anorectal fistulae. Illustratively, an anorectal fistula can be treated by placing a volumetric construct within the primary opening of the fistula. In certain embodiments, the volumetric construct can include a rolled remodelable material processed to form a substantially unitary body. Advantageous such remodelable materials can include collagenous extracellular matrix materials, such as small intestine submucosa.
摘要翻译： 描述了可用于治疗瘘的装置，方法和系统，并且在某些实施例中，具有延伸进入消化道的开口的那些，诸如肛门直肠瘘。 说明性地，可以通过在瘘的初级开口内放置体积结构来治疗肛门直肠瘘。 在某些实施方案中，体积构造可以包括经加工以形成基本上单体的卷状可重塑材料。 有益的这种可重塑材料可以包括胶原细胞外基质材料，如小肠粘膜下层。
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公开(公告)号：US08915941B2
公开(公告)日：2014-12-23
申请号：US13517801
申请日：2012-06-14
CPC分类号： A61B17/0057 , A61B2017/00588 , A61B2017/00641
摘要： Described are methods and systems for treating fistulae and other passageways and openings in the body. In certain aspects, an anchored suture is provided that extends from at or near a first fistula opening and through a fistula tract toward a second fistula opening. Various modes of anchoring may be used in this regard including, in some modes, having the suture extend from a deployed anchoring member positioned in and/or around the first opening. The anchored suture, which has a more slender cross sectional dimension relative to the fistula tract through which it extends, is capable of receiving an optional fill substance therealong in the tract. A fill substance can be or include a variety of biodegradable and/or non-biodegradable objects and materials including flowable and non-flowable materials.
摘要翻译： 描述了用于治疗瘘管和身体其他通道和开口的方法和系统。 在某些方面，提供一种锚固缝合线，其从第一瘘开口处或附近延伸并且通过瘘道朝向第二瘘开口延伸。 在这方面可以使用各种锚固模式，包括在一些模式中，缝合线从位于第一开口中和/或周围的展开的锚定构件延伸。 相对于其延伸的瘘管具有更细长的横截面尺寸的锚定缝合线能够在管道中接收可选的填充物质。 填充物质可以是或包括各种可生物降解和/或不可生物降解的物体和材料，包括可流动和不可流动的材料。
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公开(公告)号：US08834351B2
公开(公告)日：2014-09-16
申请号：US13048492
申请日：2011-03-15
CPC分类号： A61L27/3633 , A61F2/2475 , A61L27/3604 , A61L27/3641 , A61L27/3645 , A61L27/3839
摘要： This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls. Additionally the biomaterial can include a variety of naturally occurring or added bioactive agents and/or viable cellular populations.
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