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公开(公告)号：US20110136756A1
公开(公告)日：2011-06-09
申请号：US12993140
申请日：2009-05-22
IPC分类号： A61K31/555 , A61K31/7068 , A61P35/00
CPC分类号： A61K31/28 , A61K31/337 , A61K31/555 , A61K45/06 , A61K2300/00 , A61K31/47
摘要： The present disclosure relates to methods of treating cancers that are responsive to antimetabolite or antimitotic anti-cancer agents. The methods involve the use of at least one anti-cancer agent selected from antimetabolite anti-cancer agents, antimitotic anti-cancer agents, and combinations thereof, and a superoxide dismutase mimetic to potentiate the therapeutic effect of the anti cancer agent(s).
摘要翻译： 本公开涉及治疗对抗代谢药物或抗有丝分布的抗癌剂有反应性的癌症的方法。 所述方法包括使用至少一种选自抗代谢物抗癌剂，抗有丝分裂抗癌剂及其组合的抗癌剂，以及超氧化物歧化酶模拟物，以增强抗癌剂的治疗效果。
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公开(公告)号：US20100304415A1
公开(公告)日：2010-12-02
申请号：US12787260
申请日：2010-05-25
CPC分类号： G01N30/50 , B01D15/3828 , B01D15/3833 , B01D2015/3838 , G01N30/02 , G01N30/74 , G01N30/96 , G01N2030/027
摘要： A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
摘要翻译： 提供了一种常规和可重复检测和定量金属络合物的高效液相色谱法。 用于本发明方法的金属络合物可以是不同的金属络合物，或它们可以是相同金属络合物的立体异构体。 本发明的高效液相色谱法适用于分离相同金属络合物的非对映异构体。 还提供了用于分离金属络合物的对映异构体的手性高效液相色谱法。 还提供了超氧化物歧化酶模拟化合物。
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公开(公告)号：US5223638A
公开(公告)日：1993-06-29
申请号：US692857
申请日：1991-04-29
IPC分类号： C07C68/04 , C07C69/96 , C07C269/04 , C07C271/06 , C07C271/12 , C07C271/16 , C07C271/20 , C07C271/24 , C07C271/28 , C07C271/38 , C07C271/42 , C07D295/20 , C08G64/32 , C08G71/04
CPC分类号： C07C269/04 , C07C68/04 , C08G64/323 , C08G71/04
摘要： The present invention provides a process for preparing urethanes and carbonates from an amine or an alcohol, carbon dioxide and a hydrocarbyl halide. The amine or alcohol is reacted with carbon dioxide in a suitable solvent system and in the presence of an amidine or guanidine base, to form the ammonium carbamate or carbonate salt which is then reacted in a polar aprotic solvent with a hydrocarbyl halide. Polymer products can also be prepared utilizing this process or utilizing the resulting urethanes and carbonates under standard polymerization conditions.
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14.发明授权Rhodium complexes containing chiral phosphine ligands useful as hydrogenation catalysts 失效含有可用作氢化催化剂的手性膦配体的铑络合物
公开(公告)号：US4397787A
公开(公告)日：1983-08-09
申请号：US340443
申请日：1982-01-18
申请人： Dennis P. Riley
发明人： Dennis P. Riley
IPC分类号： B01J31/00 , B01J31/24 , C07C29/147 , C07C51/36 , C07D209/20 , C07F9/50 , C07F15/00
CPC分类号： C07F15/00 , B01J31/2291 , B01J31/2295 , B01J31/2409 , B01J31/2414 , C07C29/147 , C07C51/36 , C07D209/20 , C07F15/0073 , C07F9/5027 , B01J2231/645 , B01J2531/821 , B01J2531/822
摘要： Rhodium (1) complexes containing the chiral phosphine ligand (R)-1,2-bis(diphenylphosphino)-1-cyclohexylethane which are useful as chiral hydrogenation catalysts. These catalysts are especially useful in the chiral hydrogenation of alpha-acylamido acrylic acids.
摘要翻译： 含有可用作手性氢化催化剂的手性膦配体（R）-1,2-二（二苯基膦基）-1-环己基乙烷的铑（1）络合物。 这些催化剂特别可用于α-酰基酰氨基丙烯酸的手性氢化。
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公开(公告)号：US20130079317A1
公开(公告)日：2013-03-28
申请号：US13625617
申请日：2012-09-24
IPC分类号： A61K31/555 , A61P9/00 , A61P17/00 , A61P1/00 , A61P37/00 , A61P29/00 , A61P3/00 , A61P25/00 , A61P27/02 , A61P11/00 , A61P17/06 , A61P17/10 , A61P17/14 , A61P17/12 , A61P11/06 , A61P37/08 , A61P1/04 , A61P11/02 , A61P9/10 , A61P19/02 , A61P7/06 , A61P19/08 , A61P19/10 , A61P7/02 , A61P25/14 , A61P25/16 , A61P13/12 , A61P31/00 , A61P35/04 , A61P1/16 , A61P35/00
CPC分类号： A61K31/555 , A61K9/0019 , A61K9/08 , A61K9/19
摘要： The present disclosure relates to methods of treating a range of diseases or conditions. The methods involve administration of a superoxide dismutase mimetic.
摘要翻译： 本公开涉及治疗一系列疾病或病症的方法。 所述方法包括施用超氧化物歧化酶模拟物。
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公开(公告)号：US20120314203A1
公开(公告)日：2012-12-13
申请号：US13569733
申请日：2012-08-08
CPC分类号： G01N30/50 , B01D15/3828 , B01D15/3833 , B01D2015/3838 , G01N30/02 , G01N30/74 , G01N30/96 , G01N2030/027
摘要： A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
摘要翻译： 提供了一种常规和可重复检测和定量金属络合物的高效液相色谱法。 用于本发明方法的金属络合物可以是不同的金属络合物，或它们可以是相同金属络合物的立体异构体。 本发明的高效液相色谱法适用于分离相同金属络合物的非对映异构体。 还提供了用于分离金属络合物的对映异构体的手性高效液相色谱法。 还提供了超氧化物歧化酶模拟化合物。
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公开(公告)号：US5260473A
公开(公告)日：1993-11-09
申请号：US976809
申请日：1992-11-16
申请人： William D. McGhee , Dennis P. Riley
发明人： William D. McGhee , Dennis P. Riley
IPC分类号： C07C68/04 , C07C269/04 , C08G64/32 , C08G71/04 , C07C69/96
CPC分类号： C08G71/04 , C07C269/04 , C07C68/04 , C08G64/323
摘要： The present invention provides a process for preparing urethanes and carbonates from an amine or an alcohol, carbon dioxide and a hydrocarbyl halide. The amine or alcohol is reacted with carbon dioxide in a suitable solvent system and in the presence of an amidine or guanidine base, to form the ammonium carbamate or carbonate salt which is then reacted in a polar aprotic solvent with a hydrocarbyl halide. Polymer products can also be prepared utilizing this process or utilizing the resulting urethanes and carbonates under standard polymerization conditions.
摘要翻译： 本发明提供了由胺或醇，二氧化碳和烃基卤化物制备氨基甲酸酯和碳酸酯的方法。 胺或醇在合适的溶剂体系中和在脒或胍碱的存在下与二氧化碳反应，形成氨基甲酸铵或碳酸盐，然后在极性非质子溶剂中与烃基卤化物反应。 也可以使用该方法制备聚合物产物，或者在标准聚合条件下利用所得的聚氨酯和碳酸酯。
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公开(公告)号：US4965402A
公开(公告)日：1990-10-23
申请号：US311786
申请日：1989-02-17
IPC分类号： B01J27/053 , B01J27/08 , B01J27/128 , B01J27/24 , B01J27/25 , B01J31/04 , B01J31/22 , C07B61/00 , C07F9/38 , C07F9/40
CPC分类号： C07F9/3813
摘要： A process for producing N-phosphonomethylglycine by the oxidation of N-phosphonomethyliminodiacetic acid using a molecular oxygen-containing gas in the presence of a transition metal catalyst.
摘要翻译： 一种通过在过渡金属催化剂存在下使用含分子氧的气体氧化N-膦酰基甲基亚氨基二乙酸生产N-膦酰基甲基甘氨酸的方法。
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公开(公告)号：US4952723A
公开(公告)日：1990-08-28
申请号：US386738
申请日：1989-07-31
IPC分类号： B01J27/053 , B01J27/08 , B01J27/128 , B01J27/24 , B01J27/25 , B01J31/02 , B01J31/04 , B01J31/22 , B01J31/26 , C07B61/00 , C07F9/38 , C07F9/40
CPC分类号： C07F9/3813
摘要： A process for the production of N-phosphonomethylglycine comprising contacting N-phosphonomethyliminodiacetic acid with a molecular oxygen-containing gas in the presence of a catalyst selected from the group consisting of the salts and salt complexes of manganese, cobalt, iron, nickel, chromium, ruthenium, aluminum, moleybdenum, vanadium and cerium, and an effective amount of a dipyridyl compound.
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公开(公告)号：US09222922B2
公开(公告)日：2015-12-29
申请号：US14330745
申请日：2014-07-14
CPC分类号： G01N30/50 , B01D15/3828 , B01D15/3833 , B01D2015/3838 , G01N30/02 , G01N30/74 , G01N30/96 , G01N2030/027
摘要： A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes. The high performance liquid chromatography method of the present invention is suitable for the separation of diastereomers of the same metal complexes. Also provided is a chiral high performance liquid chromatography method to separate enantiomers of metal complexes. Superoxide dismutase mimetic compounds are also provided.
摘要翻译： 提供了一种常规和可重复检测和定量金属络合物的高效液相色谱法。 用于本发明方法的金属络合物可以是不同的金属络合物，或它们可以是相同金属络合物的立体异构体。 本发明的高效液相色谱法适用于分离相同金属络合物的非对映异构体。 还提供了用于分离金属络合物的对映异构体的手性高效液相色谱法。 还提供了超氧化物歧化酶模拟化合物。
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