利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

41 条记录 (耗时 0.029 秒)

    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes
    13.
    发明授权
    Pharmacologically active O-acyl-2,3-diaryl-3-halogeno-acryl-aldoximes 失效
    药理活性的O-酰基-2,3-二芳基-3-卤代丙烯酰基肟

    公开(公告)号：US4056629A

    公开(公告)日：1977-11-01

    申请号：US716277

    申请日：1976-08-20

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ernold Granzer ,  Josef Musil ,  Hermann Teufel

    IPC分类号： A61K20060101 ,  A61K31/15 ,  A61K31/215 ,  A61K31/27 ,  C07C20060101

    CPC分类号： C07D417/04

    摘要： A medicament consisting of or containing an O-acyl-2,3-diaryl-3-halogeno-acrylaldoxime of the formula I ##STR1## in which X represents a chlorine or bromine atom, R stands for an alkyl, alkenyl, alkoxy, alkenoxy or alkylamino group having from 1 to 12 carbon atoms each, or for an aryl, aryloxy, arylalkyl, arylalkoxy, arylamino or arylalkylamino group substituted optionally by 1 or 2 alkyl groups each having from 1 to 6 carbon atoms, and R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are identical or different, each representing a hydrogen atom, a halogen atom or an alkyl or alkoxy group having each from 1 to 6 carbon atoms, a process for preparing them and a method for the treatment of disorders of the purine metabolism.

    摘要翻译： 由式I（I）的O-酰基-2,3-二芳基-3-卤代 - 丙烯醛肟组成或含有其中X表示氯或溴原子的药​​物，R代表烷基，烯基， 或具有1至12个碳原子的芳基，芳氧基，芳基烷基，芳基烷氧基，芳基氨基或芳基烷基氨基，任选地被1或2个具有1至6个碳原子的烷基取代的烷氧基，链烯氧基或烷基氨基， R2，R3和R4相同或不同，各自表示氢原子，卤素原子或具有1至6个碳原子的烷基或烷氧基，其制备方法和治疗嘌呤病症的方法 代谢。

    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series
    14.
    发明授权
    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series 失效
    DELTA 2,4-11-脱氧-PEG系列前列腺素衍生物

    公开(公告)号：US4258057A

    公开(公告)日：1981-03-24

    申请号：US054874

    申请日：1979-07-05

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    IPC分类号： C07D317/72 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07F9/535 ,  C07F9/54 ,  A01N37/00 ,  C07C69/74

    CPC分类号： C07F9/5428 ,  C07C405/00 ,  C07F9/535

    摘要： The present invention relates to novel prostaglandin derivatives of the formula I ##STR1## which are structurally related to the naturally occurring prostaglandins and in which R.sup.1 denotes (a) hydrogen or a straight-chain or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon radical having up to ten carbon atoms or (b) a physiologically acceptable metal or NH.sub.4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine and R.sup.2 denotes a straight-chain, aliphatic hydrocarbon radical having up to six carbon atoms and to a process for their manufacture.The compounds of the invention are distinguished in particular by gastric acid secretion-inhibiting and ulcer-protective properties.

    摘要翻译： 本发明涉及结构上与天然存在的前列腺素相关的式I的新型前列腺素衍生物，其中R1表示（a）氢或直链或支链，饱和或不饱和的脂族或脂环族烃基 具有至多10个碳原子或（b）生理上可接受的金属或NH 4离子或衍生自伯，仲或叔胺的铵离子，R 2表示具有至多6个碳原子的直链脂族烃基， 到他们的制造过程。 本发明的化合物特别区别于胃酸分泌抑制和溃疡保护性质。

    Novel cyclopentane derivatives
    15.
    发明授权
    Novel cyclopentane derivatives 失效
    新型环戊烷衍生物

    公开(公告)号：US4097496A

    公开(公告)日：1978-06-27

    申请号：US698842

    申请日：1976-06-23

    申请人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    发明人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    IPC分类号： C07C405/00

    CPC分类号： C07C405/00

    摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.

    摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学性质的药物。

    Cyclopentane derivatives
    18.
    发明授权
    Cyclopentane derivatives 失效
    环戊烷衍生物

    公开(公告)号：US4083990A

    公开(公告)日：1978-04-11

    申请号：US698843

    申请日：1976-06-23

    申请人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    发明人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    IPC分类号： C07C405/00 ,  C07C177/00 ,  C07D309/06

    CPC分类号： C07C405/00

    摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.

    摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学性质的药物。