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    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series
    7.
    发明授权
    Prostaglandin derivatives of the .DELTA.2,4-11-deoxy-PEG series 失效
    DELTA 2,4-11-脱氧-PEG系列前列腺素衍生物

    公开(公告)号：US4258057A

    公开(公告)日：1981-03-24

    申请号：US054874

    申请日：1979-07-05

    申请人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    发明人： Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch ,  Martin Bickel

    IPC分类号： C07D317/72 ,  A61K31/557 ,  A61K31/5575 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07F9/535 ,  C07F9/54 ,  A01N37/00 ,  C07C69/74

    CPC分类号： C07F9/5428 ,  C07C405/00 ,  C07F9/535

    摘要： The present invention relates to novel prostaglandin derivatives of the formula I ##STR1## which are structurally related to the naturally occurring prostaglandins and in which R.sup.1 denotes (a) hydrogen or a straight-chain or branched, saturated or unsaturated aliphatic or cycloaliphatic hydrocarbon radical having up to ten carbon atoms or (b) a physiologically acceptable metal or NH.sub.4 ion or an ammonium ion which is derived from a primary, secondary or tertiary amine and R.sup.2 denotes a straight-chain, aliphatic hydrocarbon radical having up to six carbon atoms and to a process for their manufacture.The compounds of the invention are distinguished in particular by gastric acid secretion-inhibiting and ulcer-protective properties.

    摘要翻译： 本发明涉及结构上与天然存在的前列腺素相关的式I的新型前列腺素衍生物，其中R1表示（a）氢或直链或支链，饱和或不饱和的脂族或脂环族烃基 具有至多10个碳原子或（b）生理上可接受的金属或NH 4离子或衍生自伯，仲或叔胺的铵离子，R 2表示具有至多6个碳原子的直链脂族烃基， 到他们的制造过程。 本发明的化合物特别区别于胃酸分泌抑制和溃疡保护性质。

    Novel cyclopentane derivatives
    8.
    发明授权
    Novel cyclopentane derivatives 失效
    新型环戊烷衍生物

    公开(公告)号：US4097496A

    公开(公告)日：1978-06-27

    申请号：US698842

    申请日：1976-06-23

    申请人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    发明人： Milos Babej ,  Wilhelm Bartmann ,  Gerhard Beck ,  Ulrich Lerch

    IPC分类号： C07C405/00

    CPC分类号： C07C405/00

    摘要： The present invention relates to novel not naturally occurring 10,11-dihydro-derivatives of prostaglandins of the A-series as well as a process for their preparation. The compounds of the invention have an antiprostaglandin effect and may be used as medicaments for the inhibition or suppression of pharmacological properties of the prostaglandins.

    摘要翻译： 本发明涉及A系列前列腺素的新型非天然存在的10,11-二氢衍生物及其制备方法。 本发明的化合物具有抗前列腺素效应，可用作抑制或抑制前列腺素药理学性质的药物。

    Novel prostaglandin derivatives
    10.
    发明授权
    Novel prostaglandin derivatives 失效
    新型前列腺素衍生物

    公开(公告)号：US4182773A

    公开(公告)日：1980-01-08

    申请号：US816207

    申请日：1977-07-15

    申请人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    发明人： Wilhelm Bartmann ,  Ulrich Lerch ,  Hermann Teufel ,  Bernward Scholkens ,  Gerhard Beck

    IPC分类号： C07D339/08 ,  A61K31/19 ,  A61K31/215 ,  A61P43/00 ,  C07C67/00 ,  C07C401/00 ,  C07C405/00 ,  C07D317/72 ,  C07D339/06 ,  C07C177/00

    CPC分类号： C07D317/72 ,  C07C405/00 ,  C07D339/06

    摘要： What is disclosed are prostaglandin-analogous cyclopentane derivatives of the formula I ##STR1## wherein R.sup.1 is hydrogen or a linear or branched, saturated or unsaturated aliphatic or cycloaliphatic radical having from 1 to 8 carbon atoms, or an araliphatic radical having from 7 to 9 carbon atoms, or a physiologically tolerable metal, NH.sub.4 or substituted ammonium ion derived from a primary, secondary or tertiary amine;R.sup.2 is a linear or branched, saturated or unsaturated aliphatic hydrocarbon radical having from 1 to 8 carbon atoms;R.sup.3 is hydrogen or a R.sup.4 CO group wherein R.sup.4 is a hydrogen atom or a linear or branched alkyl group having up to 10 carbon atoms;A is a saturated, linear or branched alkylene group having from 2 to 5 carbon atoms, and a process for the manufacture thereof.

    摘要翻译： 公开的是具有式I的前列腺素类似环戊烷衍生物，其中R 1是氢或具有1至8个碳原子的直链或支链，饱和或不饱和的脂族或脂环族基团，或具有7至9个 碳原子或生理上可耐受的金属，NH 4或衍生自伯，仲或叔胺的取代的铵离子; R2是具有1至8个碳原子的直链或支链饱和或不饱和的脂族烃基; R3是氢或R4CO基，其中R4是氢原子或具有至多10个碳原子的直链或支链烷基; A是具有2至5个碳原子的饱和直链或支链亚烷基及其制备方法。