公开(公告)号：US20060078900A1

公开(公告)日：2006-04-13

申请号：US11036196

申请日：2005-01-18

申请人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

发明人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G06F19/20 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知肾毒素的组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US07415358B2

公开(公告)日：2008-08-19

申请号：US10152319

申请日：2002-05-22

申请人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

发明人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

IPC分类号： G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q2600/142 ,  C12Q2600/158 ,  G06F19/20 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知肾毒素的组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US20070054269A1

公开(公告)日：2007-03-08

申请号：US10541937

申请日：2004-01-08

申请人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

发明人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

IPC分类号： C12Q1/68 ,  G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q2600/142

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

公开(公告)号：US20070043515A1

公开(公告)日：2007-02-22

申请号：US11059535

申请日：2005-02-17

申请人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

发明人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

IPC分类号： G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： G01N33/5014 ,  G01N33/5023 ,  G01N33/5067 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US20070015146A1

公开(公告)日：2007-01-18

申请号：US10301856

申请日：2002-11-22

申请人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Arthur Castle ,  Brandon Higgs ,  Michael Elashoff

发明人： Donna Mendrick ,  Mark Porter ,  Kory Johnson ,  Arthur Castle ,  Brandon Higgs ,  Michael Elashoff

IPC分类号： C12Q1/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC分类号： C12Q1/6876 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N33/5014 ,  G01N33/5044 ,  G16B25/00 ,  G16C20/30

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

公开(公告)号：US20110071767A1

公开(公告)日：2011-03-24

申请号：US11547759

申请日：2005-04-07

申请人： Mark Porter ,  Brandon Higgs ,  Donna Mendrick ,  Michael Elashoff

发明人： Mark Porter ,  Brandon Higgs ,  Donna Mendrick ,  Michael Elashoff

IPC分类号： G01N33/52 ,  G01N33/48

CPC分类号： G01N33/5014 ,  G01N33/5067

摘要： The present invention includes methods of predicting hepatotoxicity of test agents and methods of generating hepatotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.

摘要翻译： 本发明包括使用用于分析定量基因表达信息的算法来预测测试剂的肝毒性的方法和产生肝毒性预测模型的方法。 本发明还包括微阵列，包括毒性预测模型的计算机系统，以及由远程用户使用计算机系统来确定测试剂的毒性的方法。

公开(公告)号：US07447594B2

公开(公告)日：2008-11-04

申请号：US10338044

申请日：2003-01-08

申请人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

发明人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur Castle ,  Michael Elashoff

IPC分类号： G06F19/00

CPC分类号： C12Q1/6883 ,  C12Q1/6837 ,  C12Q2600/142 ,  C12Q2600/158 ,  G01N2500/00 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知心脏毒素的组织或细胞中毒性标志物的鉴定。 该基因可用作药物筛选和毒性测定中的毒性标记物。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US07469185B2

公开(公告)日：2008-12-23

申请号：US10357507

申请日：2003-02-04

申请人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur L. Castle ,  Michael Orr ,  Michael R. Elashoff

发明人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur L. Castle ,  Michael Orr ,  Michael R. Elashoff

IPC分类号： G06F19/00

CPC分类号： G01N33/5014 ,  C12Q1/6876 ,  C12Q2600/158 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US20090197258A1

公开(公告)日：2009-08-06

申请号：US12043666

申请日：2008-03-06

申请人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur L. Castle ,  Michael Orr ,  Michael R. Elashoff

发明人： Donna L. Mendrick ,  Mark W. Porter ,  Kory R. Johnson ,  Brandon Higgs ,  Arthur L. Castle ,  Michael Orr ,  Michael R. Elashoff

IPC分类号： C12Q1/68

CPC分类号： G01N33/5014 ,  C12Q1/6876 ,  C12Q2600/158 ,  Y10S707/99945 ,  Y10S707/99948

摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.

摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。

公开(公告)号：US20120251546A1

公开(公告)日：2012-10-04

申请号：US13393616

申请日：2010-09-02

申请人： Brandon Higgs ,  Wei Zhu ,  Chris Morehouse ,  Barbara White ,  Bahija Jallal ,  Yihong Yao

发明人： Brandon Higgs ,  Wei Zhu ,  Chris Morehouse ,  Barbara White ,  Bahija Jallal ,  Yihong Yao

IPC分类号： A61K39/395 ,  G06F19/00 ,  G01N21/64

CPC分类号： C07K16/249 ,  C07K2317/565 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/158 ,  Y02A90/24 ,  Y02A90/26

摘要： The present disclosure encompasses type-I IFN and IFNα-induced PD marker expression profiles, kits, and methods for identifying such IFNα-induced PD marker expression profiles. The type-I IFN and IFNα-induced PD marker expression profiles may also be used in, for example, methods of treating patients having a type-I IFN or IFNα-mediated disorder, methods of monitoring disease progression of patients receiving treatment with a therapeutic agent that modulates type 1 interferon activity, identifying patients as candidates to receive a therapeutic that binds to and neutralizes IFNα activity, and in diagnosing or providing a prognosis to patients having IFNα-induced disorders.

摘要翻译： 本公开内容涵盖I型IFN和IFNα诱导的PD标志物表达谱，试剂盒和用于鉴定这种IFNα诱导的PD标志物表达谱的方法。 I型IFN和IFNα诱导的PD标志物表达谱也可用于例如治疗患有I型IFN或IFNα介导的病症的患者的方法，监测接受治疗的患者的疾病进展的方法 调节1型干扰素活性的试剂，鉴定患者作为接受结合并中和IFNα活性的治疗剂的候选物，以及诊断或提供具有IFNα诱导的病症的患者的预后。