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公开(公告)号：US07590493B2
公开(公告)日：2009-09-15
申请号：US11059535
申请日：2005-02-17
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： G01N33/5014 , G01N33/5023 , G01N33/5067 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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公开(公告)号：US07426441B2
公开(公告)日：2008-09-16
申请号：US11036196
申请日：2005-01-18
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G06F19/20 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知肾毒素的组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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公开(公告)号：US20070082332A1
公开(公告)日：2007-04-12
申请号：US10338044
申请日：2003-01-08
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
CPC分类号： C12Q1/6883 , C12Q1/6837 , C12Q2600/142 , C12Q2600/158 , G01N2500/00 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知心脏毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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公开(公告)号：US20070061086A1
公开(公告)日：2007-03-15
申请号：US11600759
申请日：2006-11-17
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known cardiotoxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知心脏毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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公开(公告)号：US20110071767A1
公开(公告)日：2011-03-24
申请号：US11547759
申请日：2005-04-07
申请人： Mark Porter , Brandon Higgs , Donna Mendrick , Michael Elashoff
发明人： Mark Porter , Brandon Higgs , Donna Mendrick , Michael Elashoff
CPC分类号： G01N33/5014 , G01N33/5067
摘要： The present invention includes methods of predicting hepatotoxicity of test agents and methods of generating hepatotoxicity prediction models using algorithms for analyzing quantitative gene expression information. The invention also includes microarrays, computer systems comprising the toxicity prediction models, as well as methods of using the computer systems by remote users for determining the toxicity of test agents.
摘要翻译： 本发明包括使用用于分析定量基因表达信息的算法来预测测试剂的肝毒性的方法和产生肝毒性预测模型的方法。 本发明还包括微阵列，包括毒性预测模型的计算机系统，以及由远程用户使用计算机系统来确定测试剂的毒性的方法。
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公开(公告)号：US20070093969A1
公开(公告)日：2007-04-26
申请号：US10515325
申请日：2003-11-24
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： C12Q1/6876 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5044 , G16B25/00 , G16C20/30
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知肾毒素的肾组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其他固相探针一起使用。
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公开(公告)号：US20070027634A1
公开(公告)日：2007-02-01
申请号：US10501933
申请日：2003-01-31
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
CPC分类号： G01N33/5014 , C12Q1/6837 , C12Q1/6883 , C12Q2600/142 , G01N2800/085
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in liver tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by liver toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全局变化以及暴露于已知毒素的肝组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括设计用于与微阵列和其它固相探针一起使用的肝毒素诱导的差异表达特征的基因数据库。
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公开(公告)号：US20090220970A1
公开(公告)日：2009-09-03
申请号：US12256225
申请日：2008-10-22
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
IPC分类号： C12Q1/68
CPC分类号： G01N33/5014 , G01N33/5023 , G01N33/5067 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知毒素的组织或细胞中毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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公开(公告)号：US20070124086A1
公开(公告)日：2007-05-31
申请号：US11642647
申请日：2006-12-21
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Arthur Castle , Brandon Higgs , Michael Elashoff
IPC分类号： G06F19/00
CPC分类号： C12Q1/6876 , C12Q2600/142 , C12Q2600/158 , G01N33/5014 , G01N33/5044 , G16B25/00 , G16C20/30
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in kidney tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
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公开(公告)号：US20060078900A1
公开(公告)日：2006-04-13
申请号：US11036196
申请日：2005-01-18
申请人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
发明人： Donna Mendrick , Mark Porter , Kory Johnson , Brandon Higgs , Arthur Castle , Michael Elashoff
CPC分类号： C12Q1/6883 , C12Q2600/142 , C12Q2600/158 , G06F19/20 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is based on the elucidation of the global changes in gene expression and the identification of toxicity markers in tissues or cells exposed to a known renal toxin. The genes may be used as toxicity markers in drug screening and toxicity assays. The invention includes a database of genes characterized by toxin-induced differential expression that is designed for use with microarrays and other solid-phase probes.
摘要翻译： 本发明基于阐明基因表达的全面变化以及暴露于已知肾毒素的组织或细胞中的毒性标志物的鉴定。 这些基因可用作药物筛选和毒性测定中的毒性标记。 本发明包括以毒素诱导的差异表达为特征的基因数据库，其设计用于与微阵列和其它固相探针一起使用。
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