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    COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A CELLULOSE ETHER
    13.
    发明申请
    COMPOSITION FOR APPLICATION TO A MUCOSA COMPRISING A CELLULOSE ETHER 审中-公开
    用于包含纤维素醚的粘蛋白的组合物

    公开(公告)号：US20160228559A1

    公开(公告)日：2016-08-11

    申请号：US15023736

    申请日：2014-09-15

    Applicant: Dow Global Technologies LLC

    Inventor： Jaime Curtis-Fisk ,  True Rogers ,  Susan Jordan ,  Matthias Knarr ,  Meinolf Brackenhagen ,  Roland Adden

    IPC: A61K47/38 ,  A61K47/02 ,  A61K31/167 ,  A61K9/00

    CPC classification number: A61K47/38 ,  A61K9/0043 ,  A61K9/08 ,  A61K31/167 ,  A61K47/02

    Abstract: A composition designed for application to a mucosa comprises i) a tonicity-adjusting agent, ii) an aqueous liquid diluent, and iii) 0.1 to 6 weight percent of a cellulose ether having a viscosity of up to 8000 mPa·s, wherein the cellulose ether has anhydroglucose units joined by 1-4 linkages and has methyl groups, hydroxyalkyl groups, and optionally alkyl groups being different from methyl as substituents such that hydroxyl groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.29 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 3-positions of the anhydroglucose unit are substituted with a methyl group and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxyl groups in the 2- and 6-positions of the anhydroglucose unit are substituted with a methyl group.

    Abstract translation: 设计用于粘膜的组合物包括i）张力调节剂，ii）含水液体稀释剂，和iii）0.1至6重量％的粘度高达8000mPa·s的纤维素醚，其中纤维素 醚具有通过1-4键连接的脱水葡萄糖单元，并且具有甲基，羟基烷基和任选的不同于作为取代基的甲基的烷基，使得脱水葡萄糖单元的羟基被甲基取代，使得s23 / s26为0.29以下， 其中s23是脱水葡萄糖单元的摩尔分数，其中只有脱水葡萄糖单元的2-和3-位上的两个羟基被甲基取代，并且其中s26是脱水葡萄糖单元的摩尔分数，其中只有两个羟基在 脱水葡萄糖单元的2-位和6-位被甲基取代。

    Dispersion comprising an esterified cellulose ether
    14.
    发明授权
    Dispersion comprising an esterified cellulose ether 有权

    公开(公告)号：US10383944B2

    公开(公告)日：2019-08-20

    申请号：US15129505

    申请日：2015-03-03

    Applicant: Dow Global Technologies LLC

    Inventor： Neal J. Fetner ,  David L. Malotky ,  Jin Zhao ,  Matthias Knarr ,  Michael J. Devon ,  Roland Adden

    IPC: A61K9/28 ,  A61K47/38 ,  A61K9/48 ,  C08B13/00 ,  C08L1/32 ,  A61J3/07

    Abstract: An aqueous composition useful for producing capsules shells comprises a) at least one dispersed esterified cellulose ether comprising (i) groups of the formula —C(O)—R—COOA or (ii) a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOA, wherein R is a divalent aliphatic or aromatic hydrocarbon group and A is hydrogen or a cation, and b) from 0.05 to 20 percent of at least one salt of a fatty acid, based on the weight of the dispersed esterified cellulose ether, wherein the median particle size, d50, of the dispersed esterified cellulose ether particles is up to 7 micrometers, such median particle size (d50) being the size at which 50 mass percent of the particles have a smaller equivalent diameter and 50 mass percent have a larger equivalent diameter.

    METHODS AND COMPOSITION FOR INDUCING SATIETY
    18.
    发明申请
    METHODS AND COMPOSITION FOR INDUCING SATIETY 有权
    诱导。的方法和组成

    公开(公告)号：US20150045292A1

    公开(公告)日：2015-02-12

    申请号：US14350826

    申请日：2012-10-11

    Applicant: Dow Global Technologies LLC

    Inventor： Britta Huebner-Keese ,  Matthias Knarr ,  Roland Adden ,  Robert L. Sammler ,  Anne Adden

    IPC: A61K38/17 ,  A61K38/16 ,  A61K31/717 ,  A23L1/0534 ,  A23L1/29

    CPC classification number: A61K38/1709 ,  A23L29/262 ,  A23L33/17 ,  A23L33/185 ,  A23L33/19 ,  A23L33/24 ,  A23L33/30 ,  A23P10/20 ,  A23V2002/00 ,  A61K31/717 ,  A61K38/168 ,  A61K38/1703 ,  A23V2250/51088 ,  A23V2250/54 ,  A23V2200/332 ,  A23V2200/228

    Abstract: A flowable or spoonable medicament, food, food ingredient or food supplement is useful for inducing satiety. It comprises a protein and a methylcellulose (MC), wherein the weight ratio w(protein)/w(MC) is at least 0.7/1.0 and the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.

    Abstract translation: 可流动或可匙取的药物，食物，食物成分或食物补充剂可用于诱导饱腹感。 它包含蛋白质和甲基纤维素（MC），其中w（蛋白质）/ w（MC）的重量比为至少0.7 / 1.0，甲基纤维素具有通过1-4键连接的脱水葡萄糖单元，其中脱水葡萄糖单元的羟基被取代 其中s23 / s26为0.36以下的甲基，其中s23是脱水葡萄糖单元的摩尔分数，其中脱水葡萄糖单元的2-和3-位上的两个羟基仅被甲基取代，并且其中s26是 脱水葡萄糖单元的摩尔分数，其中仅在脱水葡萄糖单元的2-和6-位上的两个羟基被甲基取代。

    COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A SPECIFIC HYDROXYPROPYL METHYLCELLULOSE
    19.
    发明申请
    COMPOSITION COMPRISING AN ORGANIC LIQUID DILUENT AND A SPECIFIC HYDROXYPROPYL METHYLCELLULOSE 审中-公开
    包含有机液体稀释剂和特定的羟丙基甲基纤维素的组合物

    公开(公告)号：US20140024723A1

    公开(公告)日：2014-01-23

    申请号：US13942775

    申请日：2013-07-16

    Applicant: Dow Global Technologies LLC

    Inventor： Meinolf Brackhagen ,  Robert L. Schmitt ,  Matthias Knarr

    IPC: A61K47/38

    CPC classification number: A61K47/38 ,  A61K9/146 ,  A61K9/2866 ,  A61K9/5047 ,  A61K9/5089

    Abstract: A liquid composition which comprises an organic liquid diluent and at least one hydroxypropyl methylcellulose having 28 to 30 weight percent of methoxyl groups, 7 to 12 weight percent of hydroxypropoxyl groups and a sum of methoxyl groups and hydroxypropoxyl groups of from 38.5 to 42 weight percent is stable over an extended time period.The liquid composition is useful for preparing a solid dispersion comprising at least one active ingredient in at least one hydroxypropyl methylcellulose by spray-drying.Alternatively a solid dispersion can be produced by blending and extruding at least one active ingredient, at least one hydroxypropyl methylcellulose described above and optionally one or more adjuvants.

    Abstract translation: 一种液体组合物，其包含有机液体稀释剂和至少一种羟甲基纤维素，其具有甲氧基28-30重量％，羟丙氧基7-12重量％，甲氧基和羟丙氧基之和为38.5至42重量％ 在延长的时间内稳定。 液体组合物可用于通过喷雾干燥制备包含至少一种羟丙基甲基纤维素中的至少一种活性成分的固体分散体。 或者，可以通过共混和挤出至少一种活性成分，至少一种上述羟丙基甲基纤维素和任选的一种或多种佐剂来制备固体分散体。

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