公开(公告)号：US20160222108A1

公开(公告)日：2016-08-04

申请号：US14979165

申请日：2015-12-22

Applicant: DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

Inventor： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC: C07K16/28

Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US10479834B2

公开(公告)日：2019-11-19

申请号：US15830998

申请日：2017-12-04

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Christopher TenHoor ,  Malini Viswanathan

IPC: C07K16/28 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.

公开(公告)号：US09862768B2

公开(公告)日：2018-01-09

申请号：US15139784

申请日：2016-04-27

Applicant: Dyax Corp.

Inventor： Daniel J. Sexton ,  Christopher TenHoor ,  Malini Viswanathan

IPC: C07K16/28 ,  A61K49/00 ,  G01N33/68 ,  A61K39/395 ,  A61K48/00 ,  A61K39/00

CPC classification number: C07K16/283 ,  A61K39/3955 ,  A61K48/00 ,  A61K49/0002 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/94 ,  G01N33/6854

Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.

公开(公告)号：US20160252527A1

公开(公告)日：2016-09-01

申请号：US15030811

申请日：2014-10-17

Applicant: DYAX CORP.

Inventor： Daniel J. Sexton ,  Ryan Faucette ,  Jon A. Kenniston ,  Gregory P. Conley ,  Andrew Nixon ,  Christopher TenHoor ,  Burt Adelman

IPC: G01N33/68 ,  C07K16/40 ,  C12Q1/37

CPC classification number: G01N33/6893 ,  A61K2039/505 ,  C07K16/36 ,  C07K16/40 ,  C07K2317/76 ,  C12Q1/37 ,  C12Q1/56 ,  C12Y304/21034 ,  C12Y304/21038 ,  G01N2333/4713 ,  G01N2333/96455 ,  G01N2333/96458 ,  G01N2500/02 ,  G01N2500/20 ,  G01N2800/224 ,  G01N2800/50 ,  G01N2800/52

Abstract: Methods and assays for determining the activation level of the plasma kallikrein (pKal) system and the uses thereof for assessing the activity of pKal modulators on the pKal system.

Abstract translation: 用于确定血浆激肽释放酶（pKal）系统的激活水平的方法和测定及其用于评估pKal系统上pKal调节剂活性的用途。

公开(公告)号：US20160222111A1

公开(公告)日：2016-08-04

申请号：US14984075

申请日：2015-12-30

Applicant: DYAX CORP. ,  BIOGEN HEMOPHILIA INC.

Inventor： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC: C07K16/28

Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US20160222109A1

公开(公告)日：2016-08-04

申请号：US14982521

申请日：2015-12-29

Applicant: DYAX CORP. ,  Biogen Hemophilia Inc.

Inventor： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James M. McGivney ,  Kevin A. McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC: C07K16/28

Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

公开(公告)号：US20140248287A1

公开(公告)日：2014-09-04

申请号：US14168839

申请日：2014-01-30

Applicant: SYNTONIX PHARMACEUTICALS, INC. ,  DYAX CORP.

Inventor： Christopher TenHoor ,  Arumugam Muruganandam ,  Robert Charles Ladner ,  Clive Wood ,  Alan J. Bitonti ,  James Stattel ,  Kevin McDonnell ,  Liming Liu ,  Jennifer Dumont ,  Aaron K. Sato ,  Malini Viswanathan

IPC: C07K16/28

CPC classification number: C07K16/283 ,  A61K49/0058 ,  A61K49/16 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/20 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/68 ,  G01N33/6854 ,  G01N2333/70535

Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.

Abstract translation: 本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。