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公开(公告)号:US20160222110A1
公开(公告)日:2016-08-04
申请号:US14982649
申请日:2015-12-29
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US09260520B2
公开(公告)日:2016-02-16
申请号:US14168839
申请日:2014-01-30
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James McGivney , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28 , G01N33/579 , G01N33/68 , A61K39/00
CPC分类号: C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
摘要翻译: 本公开尤其提供结合FcRn的蛋白质,例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病,包括自身免疫性疾病。
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公开(公告)号:US20160222112A1
公开(公告)日:2016-08-04
申请号:US14984162
申请日:2015-12-30
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US20160194397A1
公开(公告)日:2016-07-07
申请号:US14985614
申请日:2015-12-31
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US20160222111A1
公开(公告)日:2016-08-04
申请号:US14984075
申请日:2015-12-30
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US20160222109A1
公开(公告)日:2016-08-04
申请号:US14982521
申请日:2015-12-29
申请人: DYAX CORP. , Biogen Hemophilia Inc.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US20160222108A1
公开(公告)日:2016-08-04
申请号:US14979165
申请日:2015-12-22
申请人: DYAX CORP. , BIOGEN HEMOPHILIA INC.
发明人: Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC分类号: C07K16/28
摘要: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号:US20200325469A1
公开(公告)日:2020-10-15
申请号:US16789468
申请日:2020-02-13
申请人: Dyax Corp.
摘要: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
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公开(公告)号:US09683028B2
公开(公告)日:2017-06-20
申请号:US14557171
申请日:2014-12-01
申请人: Dyax Corp.
发明人: Robert Charles Ladner , Edward Hirsch Cohen , Horacio Gabriel Nastri , Kristin L. Rookey , Rene Hoet , Hendricus Renerus Jacobus Mattheus Hoogenboom
CPC分类号: C07K16/005 , C07K2317/51 , C07K2317/515 , C07K2317/55 , C07K2317/622 , C12N15/10 , C12N15/1037 , C12N15/1093 , C12N15/66 , C40B40/02 , C40B40/08
摘要: Methods useful in constructing libraries that collectively display and/or express members of diverse families of peptides, polypeptides or proteins and the libraries produced using those methods. Methods of screening those libraries and the peptides, polypeptides or proteins identified by such screens.
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公开(公告)号:US20180291368A1
公开(公告)日:2018-10-11
申请号:US15797927
申请日:2017-10-30
申请人: Dyax Corp.
摘要: Focused libraries of vectors or genetic packages that display, display and express, or comprise a member of a diverse family of antibody peptides, polypeptides or proteins and collectively display, display and express, or comprise at least a portion of the focused diversity of the family. The libraries have length and sequence diversities that mimic that found in native human antibodies.
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