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公开(公告)号：US20150362493A1
公开(公告)日：2015-12-17
申请号：US14761690
申请日：2014-01-17
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Ryan Faucette , Jon A. Kenniston , Gregory P. Conley , Andrew Nixon , Christopher TenHoor , Burt Adelman , Yung Chyung
IPC: G01N33/573 , C07K7/06 , C07K16/40
CPC classification number: G01N33/5735 , C07K7/06 , C07K16/36 , C07K16/40 , C07K2317/21 , C07K2317/76 , G01N2333/745 , G01N2800/065 , G01N2800/102 , G01N2800/52 , G01N2800/70
Abstract: The present disclosure provides methods of evaluating a subject, e.g., a subject at risk for or suffering from a pKal-mediated or bradykinin-mediated disorder, based on values (e.g., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (KMA), or other diseases mediated by pKal useful in the evaluation and treatment. Such methods can involve the use of a detection agent that preferentially binds cleaved kininogen or intact kininogen.
Abstract translation: 本公开提供了评估受试者的方法，例如，基于pKal介导的或缓激肽介导的病症的风险或患有pKal介导的或缓激肽介导的病症的受试者，基于样品中完整和/或切割的激肽原的值（例如，百分比） 学科。 提供的方法允许对血浆激肽释放酶介导的血管性水肿（KMA）或由pKal介导的其它疾病的患者进行分析，其可用于评估和治疗。 这样的方法可以涉及使用优先结合切割的激肽原或完整激肽原的检测剂。
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公开(公告)号：US11014988B2
公开(公告)日：2021-05-25
申请号：US16594218
申请日：2019-10-07
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Christopher TenHoor , Malini Viswanathan
Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
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公开(公告)号：US20160222112A1
公开(公告)日：2016-08-04
申请号：US14984162
申请日：2015-12-30
Applicant: DYAX CORP. , BIOGEN HEMOPHILIA INC.
Inventor： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC: C07K16/28
Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号：US20160194397A1
公开(公告)日：2016-07-07
申请号：US14985614
申请日：2015-12-31
Applicant: DYAX CORP. , BIOGEN HEMOPHILIA INC.
Inventor： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC: C07K16/28
Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号：US20210309741A1
公开(公告)日：2021-10-07
申请号：US17203816
申请日：2021-03-17
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Christopher TenHoor , Malini Viswanathan
IPC: C07K16/28 , A61K49/00 , G01N33/68 , A61K39/395 , A61K48/00
Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
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Patent Agency Ranking
公开(公告)号：US20210087293A1
公开(公告)日：2021-03-25
申请号：US17010354
申请日：2020-09-02
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Burt Adelman , Yung Chyung , Christopher TenHoor , Jon A. Kenniston , Ryan Faucette , Ryan Iarrobino , Joseph Biedenkapp
IPC: C07K16/40
Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.
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公开(公告)号：US20160222110A1
公开(公告)日：2016-08-04
申请号：US14982649
申请日：2015-12-29
Applicant: DYAX CORP. , BIOGEN HEMOPHILIA INC.
Inventor： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James M. McGivney , Kevin A. McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
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公开(公告)号：US09260520B2
公开(公告)日：2016-02-16
申请号：US14168839
申请日：2014-01-30
Applicant: DYAX CORP. , BIOGEN HEMOPHILIA INC.
Inventor： Christopher TenHoor , Arumugam Muruganandam , Robert Charles Ladner , Clive Wood , Alan J. Bitonti , James McGivney , Kevin McDonnell , Liming Liu , Jennifer Dumont , Aaron K. Sato , Malini Viswanathan
IPC: C07K16/28 , G01N33/579 , G01N33/68 , A61K39/00
CPC classification number: C07K16/283 , A61K49/0058 , A61K49/16 , A61K51/1027 , A61K2039/505 , C07K16/28 , C07K2317/20 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/68 , G01N33/6854 , G01N2333/70535
Abstract: This disclosure provides, inter alia, proteins that bind to FcRn, e.g., immunoglobulins that inhibit FcRn with high affinity and selectivity. The FcRn-binding proteins can be used to treat a variety of disorders including autoimmune disorders.
Abstract translation: 本公开尤其提供结合FcRn的蛋白质，例如以高亲和力和选择性抑制FcRn的免疫球蛋白。 FcRn结合蛋白可用于治疗多种疾病，包括自身免疫性疾病。
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公开(公告)号：US20180305454A1
公开(公告)日：2018-10-25
申请号：US15830998
申请日：2017-12-04
Applicant: Dyax Corp.
Inventor： Daniel J. Sexton , Christopher TenHoor , Malini Viswanathan
Abstract: The disclosure relates to antibodies that bind FcRn and methods of using these antibodies.
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10.发明申请PLASMA KALLIKREIN BINDING PROTEINS AND USES THEREOF IN TREATING HEREDITARY ANGIOEDEMA 审中-公开PLASMA KALLIKREIN结合蛋白及其在治疗放疗中的应用公开(公告)号：US20170002094A1
公开(公告)日：2017-01-05
申请号：US15113297
申请日：2015-01-21
Applicant: DYAX CORP.
Inventor： Daniel J. Sexton , Burt Adelman , Yung Chyung , Christopher TenHoor , Jon A. Kenniston , Ryan Faucette , Rayan larrobino , Joe Biedenkapp
IPC: C07K16/40
CPC classification number: C07K16/40 , A61K2039/505 , A61K2039/545 , C07K2317/565 , C07K2317/76 , C07K2317/92
Abstract: Provided herein are plasma kallikrein binding proteins such as antibodies binding to active plasma kallikrein and methods of using such proteins in treating hereditary angioedema.
Abstract translation: 本文提供血浆激肽释放酶结合蛋白，例如结合活性血浆激肽释放酶的抗体以及使用这些蛋白质治疗遗传性血管性水肿的方法。
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