公开(公告)号：US20190292162A1

公开(公告)日：2019-09-26

申请号：US16302564

申请日：2017-05-17

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Honglin LI ,  Yufang XU ,  Rui WANG ,  Zhenjiang ZHAO ,  Wenlin SONG ,  Liuxin XU

IPC: C07D277/50 ,  A61P19/02

Abstract: A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.

公开(公告)号：US20170313715A1

公开(公告)日：2017-11-02

申请号：US15523058

申请日：2015-10-30

Applicant: EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ,  SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Honglin LI ,  Hualiang JIANG ,  Yufang XU ,  Jia LI ,  Zhenjiang ZHAO ,  Jingya LI ,  Hongling XU ,  Shiliang LI

IPC: C07D493/04 ,  C07D311/92 ,  C07D311/60

Abstract: The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.