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公开(公告)号：US20170313715A1
公开(公告)日：2017-11-02
申请号：US15523058
申请日：2015-10-30
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Honglin LI , Hualiang JIANG , Yufang XU , Jia LI , Zhenjiang ZHAO , Jingya LI , Hongling XU , Shiliang LI
IPC分类号： C07D493/04 , C07D311/92 , C07D311/60
摘要： The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.
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公开(公告)号：US20180148454A1
公开(公告)日：2018-05-31
申请号：US15577518
申请日：2016-05-30
发明人： Honglin LI , Yufang XU , Zhenjiang ZHAO , Wei ZHOU , Yuqiong XU , Deheng SUN , Xia WANG , Zhuo CHEN
IPC分类号： C07D487/04 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P35/02 , C07D475/00
摘要： The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
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公开(公告)号：US20220098134A1
公开(公告)日：2022-03-31
申请号：US17424105
申请日：2020-06-12
发明人： Honglin LI , Zhenjiang ZHAO , Rui WANG , Yinchu SHEN , Jianjun FU , Yufang XU , Xuhong QIAN , Qian JIAO , Shiliang LI
摘要： The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.
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公开(公告)号：US20190290620A1
公开(公告)日：2019-09-26
申请号：US16302574
申请日：2017-05-17
发明人： Honglin LI , Zhenjiang ZHAO , Rui WANG , Yufang XU , Wanqi WANG , Yingfang YANG
IPC分类号： A61K31/426 , A61P1/04
摘要： The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis:
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公开(公告)号：US20210155604A1
公开(公告)日：2021-05-27
申请号：US17047002
申请日：2019-04-12
发明人： Honglin LI , Jian DING , Yufang XU , Hua XIE , Qiannan LI , Tao ZHANG , Zhenjiang ZHAO
IPC分类号： C07D401/14 , C07D401/12 , C07F9/6558 , C07D239/94 , C07D403/12
摘要： Related to a quinazoline compound serving as an EFGR triple mutation inhibitor and applications thereof. Specifically, disclosed are a compound as represented by the following formula (I), a pharmaceutical composition comprising the compound of formula (I), and applications of the compound in treating a related disease mediated by EGFR and in a medicament for treating the related disease mediated by EGFR.
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公开(公告)号：US20190292162A1
公开(公告)日：2019-09-26
申请号：US16302564
申请日：2017-05-17
发明人： Honglin LI , Yufang XU , Rui WANG , Zhenjiang ZHAO , Wenlin SONG , Liuxin XU
IPC分类号： C07D277/50 , A61P19/02
摘要： A thiazole derivative serving as a DHODH inhibitor, and applications thereof. The present invention specifically relates to a compound represented by formula I, a pharmaceutical composition containing the compound represented by formula (I), and applications of the compound in the preparation of drugs for treating diseases mediated by the DHODH or drugs for inhibiting the DHODH.
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7.发明公开公开(公告)号：US20230310333A1
公开(公告)日：2023-10-05
申请号：US18043594
申请日：2021-08-23
发明人： Weiping ZHU , Yun FU , Yufang XU , Xuhong QIAN
CPC分类号： A61K9/5115 , A61K38/28 , A61K9/0021
摘要： A mesoporous silica nanoparticle controlled release system, a preparation method thereof and an application thereof, and specifically provides a mesoporous silica nanomaterial that can be used for controlled release is disclosed. The mesoporous silica nanomaterial that can be used for controlled release comprises a mesoporous silica nanoparticle functionalized by means of a polyhydroxy compound and a nanoparticle plugging agent functionalized by means of a phenylboronic acid compound. When substrate concentration is relatively low, the nanomaterial achieves “zero early release”; when substrate concentration is relatively high, mesoporous pores blocked by the plugging agent are opened and active ingredients are released. The nanomaterial can be loaded into microneedles and microneedle array patches used to treat diabetes or to control blood sugar levels in patients.
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公开(公告)号：US20210179598A1
公开(公告)日：2021-06-17
申请号：US17046996
申请日：2019-04-12
发明人： Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU
IPC分类号： C07D413/10 , C07D401/14 , C07D405/14 , C07D213/73 , C07D401/04 , C07D401/10 , C07D487/04 , C07D471/04 , C07D401/12 , C07D417/04
摘要： Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.
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公开(公告)号：US20190134008A1
公开(公告)日：2019-05-09
申请号：US16306465
申请日：2017-06-02
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUT OF PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
发明人： Ke XU , Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU , Wenlin SONG , Yi TONG
IPC分类号： A61K31/426 , A61P31/12
摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:
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