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公开(公告)号：US20200163983A1
公开(公告)日：2020-05-28
申请号：US16630309
申请日：2018-07-12
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , YUNNAN UNIVERSITY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Honglin LI , Weilie XIAO , Lili ZHU , Lina QUAN , Qiao LI , Yanyan DIAO , Zhenjiang ZHAO , Hualiang JIANG
IPC分类号： A61K31/704 , A61P35/00 , A61K31/56
摘要： Provided are use of a saponin compound of formula (I) or (II), or a pharmaceutically acceptable salt, prodrug or solvate thereof, in the manufacture of a medicament targeting PD-1. The medicament targeting PD-1 is one which treats a disease by inhibiting PD-1 from binding to a ligand thereof. The disease may be a tumor, an infection caused by a bacterium, a virus or a fungus, or an inflammatory disease.
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公开(公告)号：US20170313715A1
公开(公告)日：2017-11-02
申请号：US15523058
申请日：2015-10-30
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
发明人： Honglin LI , Hualiang JIANG , Yufang XU , Jia LI , Zhenjiang ZHAO , Jingya LI , Hongling XU , Shiliang LI
IPC分类号： C07D493/04 , C07D311/92 , C07D311/60
摘要： The present invention relates to six-membered ring benzo derivatives as a DPP-4 inhibitor and a use thereof. In particular, the present invention relates to a compound as shown in formula I, a pharmaceutical composition containing the compound as shown in formula I and a use of the compound in the preparation of drugs for treating DPP-4 related diseases or inhibiting DPP-4.
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公开(公告)号：US20230321103A1
公开(公告)日：2023-10-12
申请号：US18043419
申请日：2021-09-01
发明人： Honglin LI , Zhenjiang ZHAO , Yanyan DIAO , Zhuo CHEN
IPC分类号： A61K31/519
CPC分类号： A61K31/519
摘要： Provided is the use of a series of pteridinones and/or a pharmaceutically acceptable salt and a prodrug thereof as a non-canonical EGFR mutant inhibitor. Specifically, the present invention relates to the use of a series of compounds as represented by formula I and a pharmaceutical composition containing the series of compounds as represented by formula I in the preparation of a drug for treating a disease containing EGFR 20insX mutation, EGFR G719X mutation and ERBB2 mutation.
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公开(公告)号：US20230190713A1
公开(公告)日：2023-06-22
申请号：US17905629
申请日：2021-03-02
发明人： Honglin LI , Ke XU , Shiliang LI , Lili ZHU , Zhenjiang ZHAO
IPC分类号： A61K31/426 , A61P31/14 , A61P31/16 , A61K31/513 , A61K31/427 , A61K31/7056 , A61K31/675 , A61K31/215 , A61K31/351 , A61K31/19 , A61K31/4706
CPC分类号： A61K31/426 , A61K31/19 , A61K31/215 , A61K31/351 , A61K31/427 , A61K31/513 , A61K31/675 , A61K31/4706 , A61K31/7056 , A61P31/14 , A61P31/16
摘要： An application of a novel thiazole derivative in the treatment of an RNA virus infection and the preparation of a drug for treating an RNA virus infection. Specifically, the present invention relates to a use of a compound represented by the following formula I and a pharmaceutical composition containing a compound represented by the following formula I in treating an RNA virus infection and preparing a drug for treating a coronavirus infection.
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公开(公告)号：US20180148454A1
公开(公告)日：2018-05-31
申请号：US15577518
申请日：2016-05-30
发明人： Honglin LI , Yufang XU , Zhenjiang ZHAO , Wei ZHOU , Yuqiong XU , Deheng SUN , Xia WANG , Zhuo CHEN
IPC分类号： C07D487/04 , A61P35/00 , A61P35/02
CPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P35/02 , C07D475/00
摘要： The present invention relates to a pteridinone derivative serving as an EGFR inhibitor and use thereof. Specifically, the present invention relates to a compound represented by the following formula I, pharmaceutical composition comprising the compound of the following formula I, and use of the compound in preparation of drugs for treating EGFR-mediated diseases or inhibiting EGFR.
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公开(公告)号：US20230097553A1
公开(公告)日：2023-03-30
申请号：US17904587
申请日：2021-02-09
发明人： Honglin LI , Ke XU , Zhenjiang ZHAO
IPC分类号： A61K31/42 , A61K31/277 , A61P31/18 , A61P31/16
摘要： An application of a compound represented by formula I or a pharmaceutically acceptable salt thereof in the preparation of a drug for treating RNA virus infection.
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公开(公告)号：US20210179598A1
公开(公告)日：2021-06-17
申请号：US17046996
申请日：2019-04-12
发明人： Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU
IPC分类号： C07D413/10 , C07D401/14 , C07D405/14 , C07D213/73 , C07D401/04 , C07D401/10 , C07D487/04 , C07D471/04 , C07D401/12 , C07D417/04
摘要： Provided is a selective JAK2 inhibitor and application thereof. In particular, it relates to the compound of the following Formula (I), and the use of the compound in the treatment of JAK2-mediated related diseases and in the preparation of the medicament for treating JAK2-mediated related diseases.
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公开(公告)号：US20190134008A1
公开(公告)日：2019-05-09
申请号：US16306465
申请日：2017-06-02
申请人： EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY , INSTITUT OF PASTEUR OF SHANGHAI, CHINESE ACADEMY OF SCIENCES
发明人： Ke XU , Honglin LI , Yufang XU , Zhenjiang ZHAO , Lili ZHU , Wenlin SONG , Yi TONG
IPC分类号： A61K31/426 , A61P31/12
摘要： Provided are applications of a thiazole derivative in treating virus infection and in the preparation of drugs for treating virus infection. Specifically, provided are applications of a compound represented by formula (I) and a pharmaceutical composition comprising the compound represented by formula (I) in treating virus infection and in the preparation of drugs for treating virus infection:
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公开(公告)号：US20220098134A1
公开(公告)日：2022-03-31
申请号：US17424105
申请日：2020-06-12
发明人： Honglin LI , Zhenjiang ZHAO , Rui WANG , Yinchu SHEN , Jianjun FU , Yufang XU , Xuhong QIAN , Qian JIAO , Shiliang LI
摘要： The present invention provides a compound as represented by formula I, or a pharmaceutically acceptable salt or ester, a prodrug, an optical isomer, a stereoisomer, or a solvate thereof. The compound provided by the present invention can be used for preparing drugs for preventing or treating hypertension, or hypertension-related diseases, or pulmonary hypertension, or pulmonary hypertension-related diseases. The compound provided by the present invention has a different mechanism from existing drugs for treating hypertension and pulmonary hypertension, thereby laying a new material foundation for the development of drugs for treating hypertension and pulmonary hypertension.
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公开(公告)号：US20190290620A1
公开(公告)日：2019-09-26
申请号：US16302574
申请日：2017-05-17
发明人： Honglin LI , Zhenjiang ZHAO , Rui WANG , Yufang XU , Wanqi WANG , Yingfang YANG
IPC分类号： A61K31/426 , A61P1/04
摘要： The present invention relates to applications of a novel thiazole derivative in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis. The present invention specifically relates to applications of a compound represented by formula I and a pharmaceutical composition containing the compound represented by formula I, in treating ulcerative colitis and in the preparation of drugs for treating ulcerative colitis:
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