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公开(公告)号：US20160332969A1
公开(公告)日：2016-11-17
申请号：US15162453
申请日：2016-05-23
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki
IPC: C07D213/64 , C07D405/12 , C07D491/113 , C07D491/048 , C07D405/14 , C07D409/12 , C07D491/08 , C07D401/12 , C07D401/14
Abstract: The present invention relates to substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US20140288041A1
公开(公告)日：2014-09-25
申请号：US14275667
申请日：2014-05-12
Applicant: EPIZYME, INC.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D405/14 , C07D405/12 , C07D401/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US08765732B2
公开(公告)日：2014-07-01
申请号：US13722807
申请日：2012-12-20
Applicant: Epizyme, Inc.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/00 , A61K31/55 , A61K31/535 , A61K31/445 , A61K31/44 , C07D281/02 , C07D243/08 , C07D419/00 , C07D401/00
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US11052093B2
公开(公告)日：2021-07-06
申请号：US16660339
申请日：2019-10-22
Applicant: Epizyme, Inc.
Inventor： Kevin W. Kuntz , Richard Chesworth , Kenneth W. Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah K. Knutson , Timothy J. N. Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: A61K31/5377 , A61K31/444 , A61K31/506 , A61K31/4412 , A61K31/553 , A61K31/551 , C07D213/64 , C07D409/12 , C07D498/08 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D405/14 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4545 , A61K31/4709 , A61K31/496
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
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公开(公告)号：US10898490B2
公开(公告)日：2021-01-26
申请号：US16660185
申请日：2019-10-22
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah K. Knutson
IPC: A61K31/5377 , A61K31/4412 , A61K31/4545 , A61P35/00 , A61K9/00
Abstract: The present disclosure relates to pharmaceutical compositions comprising inhibitor(s) of human histone methyltransferase EZH2, and methods of cancer therapy using the EZH2 inhibitor(s).
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Patent Agency Ranking
公开(公告)号：US09889138B2
公开(公告)日：2018-02-13
申请号：US15211792
申请日：2016-07-15
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack
IPC: A61K31/535 , A61K31/5377 , A61K45/06 , A61K31/45 , A61K31/453 , A61K31/5375
CPC classification number: A61K31/5377 , A61K31/45 , A61K31/453 , A61K31/5375 , A61K45/06 , A61P35/00 , A61P37/00
Abstract: The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.
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公开(公告)号：US20160346293A1
公开(公告)日：2016-12-01
申请号：US15211792
申请日：2016-07-15
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack
IPC: A61K31/5377 , A61K45/06
CPC classification number: A61K31/5377 , A61K31/45 , A61K31/453 , A61K31/5375 , A61K45/06 , A61P35/00 , A61P37/00
Abstract: The present invention provides a method for treating or alleviating a symptom of a disorder, e.g., immune evasion, cancer-cell induced immune dysfunction, reduced immune response, lowered inflammation, decreased expression of a major histocompatibility complex (MHC), or cancer, characterized by aberrant, misregulated, or increased Enhancer of Zeste Homolog 2 (EZH2) activity in a cell or subject in need thereof by contacting the cell or administering to the subject a therapeutically effective amount of an EZH2 inhibitor.
Abstract translation: 本发明提供了治疗或缓解病症症状的方法，例如免疫逃避，癌细胞诱导的免疫功能障碍，免疫应答降低，炎症降低，主要组织相容性复合物（MHC）或癌症的表达降低，特征在于 通过使细胞接触或向受试者施用治疗有效量的EZH2抑制剂，在需要的细胞或受试者中通过异常，错配或增强Zeste同源物2（EZH2）活性的增强剂。
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公开(公告)号：US20160303135A1
公开(公告)日：2016-10-20
申请号：US15101577
申请日：2014-12-08
Applicant: Epizyme, Inc.
Inventor： Heike Keilhack , Sarah K. Knutson , Kevin W. Kuntz
IPC: A61K31/5377 , A61K31/573 , A61K31/404 , A61K31/519 , C07K16/28 , A61K31/436 , A61K31/675 , A61K31/4375 , A61K31/69 , A61K39/395 , A61K31/635 , A61K31/52
CPC classification number: A61K31/5377 , A61K31/404 , A61K31/436 , A61K31/4375 , A61K31/496 , A61K31/4965 , A61K31/519 , A61K31/52 , A61K31/573 , A61K31/635 , A61K31/675 , A61K31/69 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/2887 , A61K2300/00
Abstract: The present invention relates to compositions comprising inhibitors of human histone methyltransferase EZH2 and one or more other therapeutic agents, particularly anticancer agents such as prednisone, and methods of combination therapy for administering to subjects in need thereof for the treatment of cancer.
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公开(公告)号：US20140128393A1
公开(公告)日：2014-05-08
申请号：US14054646
申请日：2013-10-15
Applicant: Epizyme, Inc.
Inventor： Sarah K. Knutson , Natalie Warholic , Heike Keilhack
IPC: C07D405/14 , C07D211/86 , C07D405/12
CPC classification number: C07D405/14 , A61K31/4412 , A61K31/4545 , A61K31/5377 , C07D211/86 , C07D405/12 , C12Q1/6886
Abstract: The present invention relates to methods of treating cancer by administering the EZH2 inhibitor compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及通过向有需要的受试者施用EZH2抑制剂化合物和药物组合物来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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公开(公告)号：US20130123234A1
公开(公告)日：2013-05-16
申请号：US13722807
申请日：2012-12-20
Applicant: EPIZYME, INC. , EISAI R&D MANAGEMENT CO., LTD.
Inventor： Kevin Wayne Kuntz , Richard Chesworth , Kenneth William Duncan , Heike Keilhack , Natalie Warholic , Christine Klaus , Sarah Kathleen Knutson , Timothy James Nelson Wigle , Masashi Seki , Syuji Shirotori , Satoshi Kawano
IPC: C07D213/64 , C07D401/12 , C07D491/08 , C07D417/12 , C07D491/107 , C07D405/14 , C07D409/12
CPC classification number: A61K31/5377 , A61K31/4412 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/553 , C07D213/64 , C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D491/08 , C07D491/107 , C07D498/08
Abstract: The present invention relates to aryl- or heteroaryl-substituted benzene compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating cancer by administering these compounds and pharmaceutical compositions to subjects in need thereof. The present invention also relates to the use of such compounds for research or other non-therapeutic purposes.
Abstract translation: 本发明涉及芳基或杂芳基取代的苯化合物。 本发明还涉及含有这些化合物的药物组合物和通过将这些化合物和药物组合物施用于有需要的受试者来治疗癌症的方法。 本发明还涉及这些化合物用于研究或其它非治疗目的的用途。
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