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49 条记录 (耗时 0.049 秒)

    Antibodies that bind CD40 and methods of treating cancer and enhancing immune responses
    13.
    发明授权
    Antibodies that bind CD40 and methods of treating cancer and enhancing immune responses 有权
    结合CD40的抗体以及治疗癌症和增强免疫应答的方法

    公开(公告)号：US07618633B2

    公开(公告)日：2009-11-17

    申请号：US11904295

    申请日：2007-09-25

    申请人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    发明人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    IPC分类号： A61K39/395 ,  C12N5/12 ,  C07K16/28

    CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  A61N5/062 ,  A61N5/10 ,  C07K16/2878 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

    摘要翻译： 本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。 本发明还涉及人抗CD40抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物。

    Antibodies to CD40
    14.
    发明申请
    Antibodies to CD40 有权
    CD40抗体

    公开(公告)号：US20090130715A1

    公开(公告)日：2009-05-21

    申请号：US12284605

    申请日：2008-09-22

    申请人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    发明人： Vahe Bedian ,  Ronald P. Gladue ,  Jose Corvalan ,  Xiao-Chi Jia ,  Xiao Feng

    IPC分类号： C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/19 ,  C12P21/00

    CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K39/3955 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  A61N5/062 ,  A61N5/10 ,  C07K16/2878 ,  C07K16/40 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/75 ,  C07K2317/92

    摘要： The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

    摘要翻译： 本发明涉及与CD40，优选人CD40特异性结合并且作为CD40激动剂起作用的抗体及其抗原结合部分。 本发明还涉及人抗CD40抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗CD40抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗CD40抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗-CD40抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物。

    Antibodies against drugs of abuse
    17.
    发明申请
    Antibodies against drugs of abuse 审中-公开
    针对滥用药物的抗体

    公开(公告)号：US20050013809A1

    公开(公告)日：2005-01-20

    申请号：US10725962

    申请日：2003-12-02

    申请人： Samuel Owens ,  Frank Carroll ,  Philip Abraham ,  Melinda Gunnell ,  Mary Haak-Frendscho ,  Xiao Feng

    发明人： Samuel Owens ,  Frank Carroll ,  Philip Abraham ,  Melinda Gunnell ,  Mary Haak-Frendscho ,  Xiao Feng

    IPC分类号： C07K16/44 ,  A61K39/395 ,  C07K16/18 ,  C12N5/06

    CPC分类号： C07K16/44 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567

    摘要： The present invention is related to antibodies directed to various drugs of abuse and uses of such antibodies. In preferred embodiments, the drugs of abuse are amphetamine, methamphetamine, or phencyclidine (PCP). In particular, in accordance with the present invention, there are provided fully man monoclonal antibodies directed to drugs of abuse. Nucelotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR3 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.

    摘要翻译： 本发明涉及针对各种滥用药物的抗体和使用此类抗体的抗体。 在优选的实施方案中，滥用药物是苯丙胺，甲基苯丙胺或苯环利定（PCP）。 特别地，根据本发明，提供了针对滥用药物的完全人单克隆抗体。 编码Nuclotide序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR3或CDR1至CDR3 ，提供。 还提供了表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。