公开(公告)号：US20060069145A1

公开(公告)日：2006-03-30

申请号：US11233408

申请日：2005-09-23

申请人： Georges Guy ,  Bernhard Goller ,  Hans-Willi Krell ,  Klaus-Peter Kuenkele ,  Anja Limberg ,  Petra Rueger ,  Matthias Rueth

发明人： Georges Guy ,  Bernhard Goller ,  Hans-Willi Krell ,  Klaus-Peter Kuenkele ,  Anja Limberg ,  Petra Rueger ,  Matthias Rueth

IPC分类号： A61K31/4184 ,  C07D487/02

CPC分类号： A61K31/4184 ,  C07D487/04 ,  C07D487/10

摘要： The present invention relates to compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明涉及式I化合物

公开(公告)号：US20090227578A1

公开(公告)日：2009-09-10

申请号：US11988813

申请日：2006-07-28

申请人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

发明人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

IPC分类号： A61K31/5377 ,  C07D471/04 ,  A61K31/437

CPC分类号： C07D471/04

摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, pharmaceutical compositions containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

摘要翻译： 本发明的目的是式I化合物，其药学上可接受的盐，对映异构体形式，非对映异构体和外消旋物，上述化合物的制备，含有它们的药物组合物及其制备方法以及使用上述 控制或预防疾病如癌症的化合物。

公开(公告)号：US07494993B2

公开(公告)日：2009-02-24

申请号：US11660197

申请日：2005-08-30

申请人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

发明人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

IPC分类号： C07D413/14 ,  C07D487/04 ,  A61K31/497 ,  A61K31/519 ,  A61K31/5355

CPC分类号： C07D487/04

摘要： The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

摘要翻译： 本发明涉及7-氨基-3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性的用途 代理商 本发明的衍生物是通式（I）的新化合物。

公开(公告)号：US20080032970A1

公开(公告)日：2008-02-07

申请号：US11660197

申请日：2005-08-30

申请人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolgfang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

发明人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolgfang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

IPC分类号： A61K31/519 ,  A61K31/496 ,  A61K31/535 ,  A61P43/00 ,  C07D239/70 ,  C07D413/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel amide derivatives of 7-amino-3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

摘要翻译： 本发明涉及7-氨基-3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性的用途 代理商 本发明的衍生物是通式（I）的新化合物。

公开(公告)号：US20070232611A1

公开(公告)日：2007-10-04

申请号：US11660198

申请日：2005-08-30

申请人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

发明人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

摘要翻译： 本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 本发明的衍生物是通式（I）的新化合物。

公开(公告)号：US07655651B2

公开(公告)日：2010-02-02

申请号：US11660198

申请日：2005-08-30

申请人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

发明人： Richard Engh ,  Hubert Hertenberger ,  Konrad Honold ,  Birgit Masjost ,  Petra Rueger ,  Wolfgang Schaefer ,  Stefan Scheiblich ,  Manfred Schwaiger

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61K31/5355 ,  C07D239/38 ,  A61P29/00 ,  A61P35/00 ,  A61P19/08 ,  A61P25/00

CPC分类号： C07D487/04

摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).

摘要翻译： 本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。 本发明的衍生物是通式（I）的新化合物。

公开(公告)号：US20050282250A1

公开(公告)日：2005-12-22

申请号：US11000867

申请日：2004-12-01

申请人： Hubert Hertenberger ,  Konrad Honold ,  Christian Klein ,  Petra Rueger

发明人： Hubert Hertenberger ,  Konrad Honold ,  Christian Klein ,  Petra Rueger

IPC分类号： C12N9/12 ,  C12N15/11 ,  C12P21/06

CPC分类号： C12N9/1205

摘要： A method for the recombinant production and purification of a protein kinase selected from the group consisting of tyrosine protein kinases and serine/threonine kinases by expressing a nucleic acid encoding said kinase in a microbial host cell, forming inclusion bodies containing said kinase, isolating, solubilizing, naturing, and purifying said kinase wherein said purification is performed by hydrophobic interaction with an hydrophobic adsorbent under conditions whereby at least 70% of said protein kinase are not bound to said adsorbent and the protein kinase not bound to said adsorbent is recovered.

摘要翻译： 一种通过在微生物宿主细胞中表达编码所述激酶的核酸，重组产生和纯化选自酪氨酸蛋白激酶和丝氨酸/苏氨酸激酶的方法，形成含有所述激酶的包涵体，分离，增溶 ，变性和纯化所述激酶，其中所述纯化通过与疏水性吸附剂的疏水相互作用进行，其中至少70％的所述蛋白激酶不与所述吸附剂结合，并且不结合所述吸附剂的蛋白激酶被回收。

公开(公告)号：US06627439B2

公开(公告)日：2003-09-30

申请号：US09886683

申请日：2001-06-21

申请人： Thorsten Hoevel ,  Stefan Koch ,  Manfred Kubbies ,  Olaf Mundigl ,  Petra Rueger

发明人： Thorsten Hoevel ,  Stefan Koch ,  Manfred Kubbies ,  Olaf Mundigl ,  Petra Rueger

IPC分类号： C12N516

CPC分类号： C07K16/18 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/34 ,  C12N2799/026 ,  C12N2799/027

摘要： Antibody binding to the SEMP1 antigen and characterized in that said antibody binds to SEMP1 in a manner equivalent to an antibody selected from the group of antibodies DSM ACC2458, DSM ACC2459, DSM ACC2461, and DSM ACC2463 is useful for cancer diagnosis and therapy.

摘要翻译： 抗体与SEMP1抗原结合，其特征在于所述抗体以与抗体DSM ACC2458，DSM ACC2459，DSM ACC2461和DSM ACC2463的抗体相当的方式结合SEMP1可用于癌症诊断和治疗。

公开(公告)号：US20070191274A1

公开(公告)日：2007-08-16

申请号：US11645014

申请日：2006-12-22

申请人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

发明人： Angelika Esswein ,  Kurt Lang ,  Petra Rueger ,  Tilman Seytter

IPC分类号： A61K38/17 ,  C07K14/47 ,  A61K31/727 ,  A61K31/185

CPC分类号： A61K31/185 ,  A61K31/727 ,  A61K38/00 ,  C07K14/47

摘要： A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.

摘要翻译： 一种刺猬蛋白缀合物，其特征在于其包含：a）由10至30个疏水氨基酸和/或氨基酸组成的多肽，其形成跨膜螺旋并带正电荷，b）1至4个脂族，饱和或不饱和的烃残基， 链长为10至24个C原子并具有疏水作用，或c）与猬蛋白共价结合的疏水性硫代化合物，并且其具有几倍增加的活性并且适于作为药剂。

公开(公告)号：US20050118169A1

公开(公告)日：2005-06-02

申请号：US10937596

申请日：2004-09-09

申请人： Ilse Bartke ,  Francis Carr ,  Richard Chizzonite ,  Elsie Eugui ,  Georg Fertig ,  Anita Hamilton ,  Martin Lanzendoerfer ,  Petra Rueger ,  Ralf Schumacher ,  Theresa Truitt

发明人： Ilse Bartke ,  Francis Carr ,  Richard Chizzonite ,  Elsie Eugui ,  Georg Fertig ,  Anita Hamilton ,  Martin Lanzendoerfer ,  Petra Rueger ,  Ralf Schumacher ,  Theresa Truitt

IPC分类号： A61K39/395 ,  C07H21/04 ,  C07K16/28 ,  C12N5/06 ,  C12N15/13

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates to antibodies against interleukin-1 receptor (IL-1R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The antibodies of the present invention are particularly useful for treating a variety of inflammatory diseases including, but not limited to, rheumatoid arthritis.

摘要翻译： 本发明涉及抗白细胞介素-1受体（IL-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 本发明的抗体特别可用于治疗各种炎性疾病，包括但不限于类风湿性关节炎。