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11.发明申请THIADIAZOLE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF DISORDERS MEDIATED BY S1P1 RECEPTORS 审中-公开三唑衍生物及其用于治疗由S1P1受体介导的疾病的用途公开(公告)号：US20120101086A1
公开(公告)日：2012-04-26
申请号：US13379110
申请日：2010-06-17
申请人： James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
发明人： James Matthew Bailey , John Alexander Brown , Emmanuel Hubert Demont , Lee Andrew Harrison , Gail Astra Lorraine Seal , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号： A61K31/55 , C07D487/04 , C07D471/04 , A61P25/00 , A61P37/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P41/00 , A61P1/00 , A61P35/00 , A61P35/04 , A61P7/00 , A61P31/12 , A61P3/10 , A61K31/437
CPC分类号： C07D471/04
摘要： The present invention relates to novel compounds having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有药理活性的新化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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12.发明申请THIAZOLE OR THIADIZALOE DERIVATIVES FOR USE AS SPHINGOSINE 1-PHOSPHATE 1 (S1P1) RECEPTOR AGONISTS 审中-公开用作磷酸1-磷酸1（S1P1）受体激动剂的噻唑或十二烷基衍生物公开(公告)号：US20120094979A1
公开(公告)日：2012-04-19
申请号：US13378809
申请日：2010-06-17
申请人： James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
发明人： James Matthew Bailey , Emmanuel Hubert Demont , Xichen Lin , Feng Ren , Christian Alan Paul Smethurst
IPC分类号： A61K31/55 , A61K31/4725 , A61K31/433 , A61P25/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P19/02 , A61P1/00 , A61P17/06 , A61P9/10 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D417/10
CPC分类号： C07D417/04
摘要： Thiazole or thiadizaloe derivatives of formula (I) or pharmaceutical salts thereof having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptor are disclosed.
摘要翻译： 公开了具有药理活性的式（I）的噻唑或噻二唑衍生物或其药用盐，其制备方法，含有它们的药物组合物及其在治疗由S1P1受体介导的各种疾病中的用途。
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![7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1H-imidazo[4,5-C]quinoline derivatives](/abs-image/US/2014/09/30/US08846709B2/abs.jpg.150x150.jpg)
13.发明授权7-(3,5-dimethyl-4-isoxazolyl)-8-(methyloxy)-1H-imidazo[4,5-C]quinoline derivatives 有权7-（3,5-二甲基-4-异恶唑基）-8-（甲氧基）-1H-咪唑并[4,5-C]喹啉衍生物公开(公告)号：US08846709B2
公开(公告)日：2014-09-30
申请号：US14111783
申请日：2012-04-19
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 新型喹啉化合物含有这些化合物的药物组合物及其在治疗中的应用。
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公开(公告)号：US20120101083A1
公开(公告)日：2012-04-26
申请号：US13379059
申请日：2010-06-17
申请人： James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
发明人： James Matthew Bailey , Rino Antonio Bit , Emmanuel Hubert Demont , Lee Andrew Harrison , Katherine Louise Jones , Christian Alan Paul Smethurst , Jason Witherington
IPC分类号： A61K31/55 , C07D417/10 , C07D413/14 , A61K31/4725 , A61P25/00 , A61P29/00 , A61P11/06 , A61P19/02 , A61P17/06 , A61P35/00 , A61P35/04 , A61P9/00 , A61P31/12 , A61P3/10 , C07D413/10
CPC分类号： C07D413/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to novel compounds of formula (I) having S1P1 agonist activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译： 本发明涉及具有S1P1激动剂活性的新型式（I）化合物，其制备方法，含有它们的药物组合物及其在治疗各种疾病中的用途。
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公开(公告)号：US20110046137A1
公开(公告)日：2011-02-24
申请号：US12599416
申请日：2008-05-08
申请人： Paul John Beswick , Laura Jane Chambers , Iain Patrick Chessell , David John Davies , Emmanuel Hubert Demont , Robert James Gleave , David George Hubert Livermore , Pamela Joan Theobald , Mythily Vimal , Daryl Simon Walter
发明人： Paul John Beswick , Laura Jane Chambers , Iain Patrick Chessell , David John Davies , Emmanuel Hubert Demont , Robert James Gleave , David George Hubert Livermore , Pamela Joan Theobald , Mythily Vimal , Daryl Simon Walter
IPC分类号： A61K31/415 , C07D231/12 , C07D403/06 , A61K31/4178 , C07D401/04 , A61K31/4439 , C07D417/04 , A61K31/427 , C07D403/04 , A61K31/501 , A61K31/506 , C07D471/08 , A61K31/439 , C07D413/06 , A61K31/5377 , A61P29/00 , A61P25/28
CPC分类号： C07D231/12 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D403/10 , C07D405/04 , C07D405/12 , C07D417/04 , C07D417/06 , C07D471/08
摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof: The pyrazole derivatives of formula (I) or salts thereof modulate P2X7 receptor function and are capable of antagonizing the effects of ATP at the P2X7 receptor (P2X7 receptor antagonists). The invention also relates to the use of such compounds or salts, or pharmaceutical compositions thereof, in the treatment or prevention of disorders/diseases mediated by the P2X7 receptor, for example pain, inflammation or a neurodegenerative disease.
摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐：式（I）的吡唑衍生物或其盐调节P2X7受体功能，并能够拮抗ATP在P2X7受体（P2X7受体） 拮抗剂）。 本发明还涉及这些化合物或其盐或其药物组合物在治疗或预防P2X7受体介导的疾病/疾病中的用途，例如疼痛，炎症或神经变性疾病。
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公开(公告)号：US09315487B2
公开(公告)日：2016-04-19
申请号：US14114545
申请日：2012-05-02
申请人： Dominique Amans , Emmanuel Hubert Demont , Katherine Louise Jones , Jonathan Thomas Seal , Ann Louise Walker
发明人： Dominique Amans , Emmanuel Hubert Demont , Katherine Louise Jones , Jonathan Thomas Seal , Ann Louise Walker
IPC分类号： A61K31/4706 , C07D401/04 , C07D401/10 , A61K31/497 , A61K45/06 , C07D401/14
CPC分类号： C07D401/04 , A61K31/4706 , A61K31/497 , A61K45/06 , C07D401/10 , C07D401/14
摘要： Tetrahydroquinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 四氢喹啉化合物含有这些化合物的药物组合物及其在治疗中的用途。
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![4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1 H-imidazo[4,5-C]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor](/abs-image/US/2015/06/30/US09067936B2/abs.jpg.150x150.jpg)
17.发明授权4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1 H-imidazo[4,5-C]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor 有权4-（8-甲氧基-1 - （（1-甲氧基丙-2-基）-2-（四氢-2H-吡喃-4-基）-1H-咪唑并[4,5-C]喹啉-7-基 ）-3,5-二甲基异恶唑及其作为溴结构域抑制剂的用途公开(公告)号：US09067936B2
公开(公告)日：2015-06-30
申请号：US14237905
申请日：2012-08-15
IPC分类号： C07D471/00 , A61K31/44 , C07D471/04 , A61K31/4745
CPC分类号： A61K31/4745 , A61K9/0053 , A61K31/437 , C07D471/04 , Y02A50/411
摘要： Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 新型喹啉化合物含有这些化合物的药物组合物及其在治疗中的应用。
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18.发明申请公开(公告)号：US20140066459A1
公开(公告)日：2014-03-06
申请号：US14114545
申请日：2012-05-02
申请人： Dominique Amans , Emmanuel Hubert Demont , Katherine Louise Jones , Jonathan Thomas Seal , Ann Louise Walker
发明人： Dominique Amans , Emmanuel Hubert Demont , Katherine Louise Jones , Jonathan Thomas Seal , Ann Louise Walker
IPC分类号： C07D401/04 , A61K31/497 , C07D401/14 , A61K31/4706 , A61K45/06
CPC分类号： C07D401/04 , A61K31/4706 , A61K31/497 , A61K45/06 , C07D401/10 , C07D401/14
摘要： Tetrahydroquinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 四氢喹啉化合物含有这些化合物的药物组合物及其在治疗中的用途。
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![7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives](/abs-image/US/2014/02/13/US20140045834A1/abs.jpg.150x150.jpg)
19.发明申请7-(3,5-Dimethyl-4-Isoxazolyl)-8-(Methyloxy)-1H-Imidazo[4,5-C]Quinoline Derivatives 有权7-（3,5-二甲基-4-异恶唑基）-8-（甲氧基）-1H-咪唑并[4,5-C]喹啉衍生物公开(公告)号：US20140045834A1
公开(公告)日：2014-02-13
申请号：US14111783
申请日：2012-04-19
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
摘要翻译： 新型喹啉化合物含有这些化合物的药物组合物及其在治疗中的应用。
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公开(公告)号：US20140039006A1
公开(公告)日：2014-02-06
申请号：US14111580
申请日：2012-04-19
IPC分类号： C07D215/44 , C07D215/42
CPC分类号： C07D215/44 , C07D215/42 , C07D401/12
摘要： Tetrahydroquinoline derivatives, pharmaceutical compositions containing such compounds and to their use in therapy.
摘要翻译： 四氢喹啉衍生物，含有这些化合物的药物组合物及其在治疗中的应用。
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