公开(公告)号：US11701351B2

公开(公告)日：2023-07-18

申请号：US17223422

申请日：2021-04-06

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K9/00 ,  A61K31/4745 ,  A61N5/10

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10 ,  A61K31/495 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.

公开(公告)号：US11660286B2

公开(公告)日：2023-05-30

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10

CPC classification number: A61K31/397 ,  A01N1/0226 ,  A61K31/12 ,  A61K31/16 ,  A61K31/198 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/40 ,  A61K31/445 ,  A61K33/00 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/6445 ,  A61N5/10 ,  Y02A50/30 ,  A61K33/00 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/445 ,  A61K2300/00 ,  A61K31/12 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/255 ,  A61K2300/00 ,  A61K31/16 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20200375982A1

公开(公告)日：2020-12-03

申请号：US16712148

申请日：2019-12-12

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K9/00 ,  A61K31/4745

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.

公开(公告)号：US20200022952A1

公开(公告)日：2020-01-23

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US09987270B1

公开(公告)日：2018-06-05

申请号：US15337378

申请日：2016-10-28

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski

IPC: A61K31/495 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10 ,  A61K9/00

CPC classification number: A61K31/495 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/397 ,  A61K31/4745 ,  A61N5/10

Abstract: The invention provides therapeutic methods and kits for treating a glioma using a particular dosing regimen of the organonitro compound ABDNAZ, radiation therapy, and one of temozolomide, irinotecan, or bevacizumab.