公开(公告)号：US11660286B2

公开(公告)日：2023-05-30

申请号：US16284035

申请日：2019-02-25

申请人： EpicentRx, Inc.

发明人： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC分类号： A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10

CPC分类号： A61K31/397 ,  A01N1/0226 ,  A61K31/12 ,  A61K31/16 ,  A61K31/198 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/40 ,  A61K31/445 ,  A61K33/00 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/6445 ,  A61N5/10 ,  Y02A50/30 ,  A61K33/00 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/445 ,  A61K2300/00 ,  A61K31/12 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/255 ,  A61K2300/00 ,  A61K31/16 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00

摘要： The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20200022952A1

公开(公告)日：2020-01-23

申请号：US16284035

申请日：2019-02-25

申请人： EpicentRx, Inc.

发明人： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC分类号： A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64

摘要： The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.