公开(公告)号：US20200046682A1

公开(公告)日：2020-02-13

申请号：US16353047

申请日：2019-03-14

Applicant: EpicentRx, Inc. ,  Northrop Grumman Innovation Systems, Inc.

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US11660286B2

公开(公告)日：2023-05-30

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10

CPC classification number: A61K31/397 ,  A01N1/0226 ,  A61K31/12 ,  A61K31/16 ,  A61K31/198 ,  A61K31/215 ,  A61K31/22 ,  A61K31/255 ,  A61K31/40 ,  A61K31/445 ,  A61K33/00 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/1709 ,  A61K45/06 ,  A61K47/6445 ,  A61N5/10 ,  Y02A50/30 ,  A61K33/00 ,  A61K2300/00 ,  A61K31/397 ,  A61K2300/00 ,  A61K31/40 ,  A61K2300/00 ,  A61K31/445 ,  A61K2300/00 ,  A61K31/12 ,  A61K2300/00 ,  A61K31/22 ,  A61K2300/00 ,  A61K31/215 ,  A61K2300/00 ,  A61K31/255 ,  A61K2300/00 ,  A61K31/16 ,  A61K2300/00 ,  A61K31/198 ,  A61K2300/00

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20200022952A1

公开(公告)日：2020-01-23

申请号：US16284035

申请日：2019-02-25

Applicant: EpicentRx, Inc.

Inventor： Bryan T. Oronsky ,  Jan Scicinski ,  Susan Knox ,  William Fitch ,  Frans A. Kuypers ,  Marcel Fens ,  Sandra Larkin ,  Pedro Cabrales ,  Chad Brouse

IPC: A61K31/397 ,  A61K33/00 ,  A61K45/06 ,  A01N1/02 ,  A61K35/14 ,  A61K35/16 ,  A61K35/18 ,  A61K38/17 ,  A61N5/10 ,  A61K31/22 ,  A61K31/12 ,  A61K31/255 ,  A61K31/445 ,  A61K31/215 ,  A61K31/16 ,  A61K31/198 ,  A61K31/40 ,  A61K47/64

Abstract: The invention provides methods, compositions, and medical kits comprising a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders and preservation of blood products. In one aspect, the invention provides methods, compositions, and medical kits comprising an inorganic nitrite salt and a nitrite-reductase promoter, such as an allosteric modulator of hemoglobin, for use in treating medical disorders, such as cancer, cardiovascular disorders, ischemic conditions, hemolytic conditions, and bacterial infections. Exemplary inorganic nitrite salts include sodium nitrite and arginine nitrite. Exemplary allosteric modulators of hemoglobin described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.

公开(公告)号：US20150246020A1

公开(公告)日：2015-09-03

申请号：US14584177

申请日：2014-12-29

Applicant: EPICENTRX, INC. ,  ALLIANT TECHSYSTEMS INC.

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20220016077A1

公开(公告)日：2022-01-20

申请号：US17186724

申请日：2021-02-26

Applicant: EpicentRx, Inc. ,  Northrop Grumman Systems Corporation

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US10149832B2

公开(公告)日：2018-12-11

申请号：US14965062

申请日：2015-12-10

Applicant: EpicentRx, Inc. ,  Orbital ATK, Inc.

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: C07D205/04 ,  A61N5/10 ,  A61K31/397 ,  A61K9/00

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20180085346A1

公开(公告)日：2018-03-29

申请号：US15669403

申请日：2017-08-04

Applicant: EpicentRx, Inc. ,  Orbital ATK, Inc.

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  C07D205/04

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US09226915B2

公开(公告)日：2016-01-05

申请号：US14584177

申请日：2014-12-29

Applicant: EpicentRx, Inc. ,  Orbital ATK, Inc.

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: C07D205/04 ,  A61K31/397

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US11925617B2

公开(公告)日：2024-03-12

申请号：US17186724

申请日：2021-02-26

Applicant: EpicentRx, Inc. ,  Northrop Grumman Systems Corporation

Inventor： Mark D. Bednarski ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397 ,  A61K9/00 ,  A61N5/10 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P35/02 ,  A61P37/06 ,  A61P43/00 ,  C07D205/02 ,  C07D205/04

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.

公开(公告)号：US20160199346A1

公开(公告)日：2016-07-14

申请号：US14965062

申请日：2015-12-10

Applicant: EpicentRx, Inc. ,  Orbital ATK, Inc.

Inventor： MARK D. BEDNARSKI ,  Susan Knox ,  Louis Cannizzo ,  Kirstin Warner ,  Robert Wardle ,  Stephen Velarde ,  Shoucheng Ning

IPC: A61K31/397 ,  A61N5/10 ,  A61K9/00

CPC classification number: A61K31/397 ,  A61K9/0019 ,  A61N5/10 ,  C07D205/04

Abstract: The present invention provides cyclic nitro compound, pharmaceutical compositions of cyclic nitro compounds and methods of using cyclic nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.