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11.发明授权Streptogramin derivatives, their preparation and compositions which contain them 失效链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US06699897B2
公开(公告)日：2004-03-02
申请号：US10400654
申请日：2003-03-28
IPC分类号： A61K3142
CPC分类号： C07D498/18 , A61K38/00 , C07K5/06139
摘要： Group A streptogramin derivatives of formula (I) and salts thereof: Group A streptogramin derivatives of formula (II) and salts thereof: and Group A streptogramin derivatives of formula (III) and salts thereof: as well as processes for preparing such streptogramins, and pharmaceutical compositions comprising such streptogramins, alone or combined with at least one group B streptogramin derivative.
摘要翻译： 式（I）的A组链霉素衍生物及其盐：式（II）的A组链霉素衍生物及其盐：和式（III）的A组链霉素衍生物及其盐：以及制备这些链霉素的方法，以及 包含这样的链霉素的药物组合物，单独或与至少一种B组链霉素衍生物组合。
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公开(公告)号：US06699895B2
公开(公告)日：2004-03-02
申请号：US10159498
申请日：2002-05-31
申请人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
发明人： Jean-Christophe Carry , Dominique Damour , Claude Guyon , Serge Mignani , Antony Bigot , Eric Bacque , Michel Tabart
IPC分类号： C07D41706
CPC分类号： C07D417/06 , A61K31/426 , A61K31/4439 , C07D277/18
摘要： The present invention relates to a class of 2-aminothiazoline derivatives of formula I: in which either R1 is a hydrogen atom or an alkyl radical and R2 is an alkyl, -alk-NH2, —CH2—R3, —CH2—S—R4 or phenyl radical substituted with a nitro or —NH—C(═NH)CH3 radical, or R1 is an alkyl radical and R2 is a hydrogen atom, R3 is a (3-6C) cycloalkyl, pyridyl, pyridyl N-oxide, thienyl, thiazolyl, imidazolyl, pyrazinyl, triazolyl or phenyl radical or a phenyl radical substituted with a nitro, hydroxy or carboxyl radical, R4 represents a pyridyl or pyridyl N-oxide radical, alk represents an alkylene radical, or pharmaceutically acceptable salts thereof, which are useful as inhibitors of inducible NO-synthase.
摘要翻译： 本发明涉及一类式I的2-氨基噻唑啉衍生物：其中R1是氢原子或烷基，R2是烷基，-alk-NH2，-CH2-R3，-CH2-S-R4 或被硝基或-NH-C（= NH）CH 3基团取代的苯基，或R 1是烷基，R 2是氢原子，R 3是（3-6C）环烷基，吡啶基，吡啶基N-氧化物，噻吩基 ，噻唑基，咪唑基，吡嗪基，三唑基或苯基或被硝基，羟基或羧基取代的苯基，R4表示吡啶基或吡啶基N-氧化物基，alk表示亚烷基或其药学上可接受的盐，它们是 可用作诱导型NO合成酶的抑制剂。
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13.发明授权Streptogramin derivatives, their preparation and compositions which contain them 失效链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US06562852B2
公开(公告)日：2003-05-13
申请号：US10024698
申请日：2001-12-21
IPC分类号： C07D49822
CPC分类号： C07D498/18 , A61K38/00 , C07K5/06139
摘要： Group A streptogramin derivatives of formula (I) and salts thereof: Group A streptogramin derivatives of formula (II) and salts thereof: and Group A streptogramin derivatives of formula (III) and salts thereof: as well as processes for preparing such streptogramins, and pharmaceutical compositions comprising such streptogramins, alone or combined with at least one group B streptogramin derivative.
摘要翻译： 式（I）的A组链霉素衍生物及其盐：式（II）的A组链霉素衍生物及其盐：和式（III）的A组链霉素衍生物及其盐：以及制备这些链霉素的方法，以及 包含这样的链霉素的药物组合物，单独或与至少一种B组链霉素衍生物组合。
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14.发明授权Streptogramin derivatives, their preparation and compositions containing them 有权链球菌素衍生物，它们的制备和含有它们的组合物公开(公告)号：US06541451B1
公开(公告)日：2003-04-01
申请号：US09627791
申请日：2000-07-27
IPC分类号： A61K3708
CPC分类号： C07D498/14 , C07K11/02
摘要： B-Group streptogramin compounds of formula (I): are useful as antimicrobial agents, optionally combined with at least one A-group streptogramin compound.
摘要翻译： 式（I）的B-组链霉素化合物：可用作抗微生物剂，任选地与至少一种A组链霉素化合物组合。
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15.发明申请NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO(1,2-A)PYRIMIDIN-6-ONE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF 有权新的1,2,3,4-四氢吡喃糖（1,2-A）嘧啶-6-酮衍生物，其制备方法及其药物用途公开(公告)号：US20120208810A1
公开(公告)日：2012-08-16
申请号：US13381790
申请日：2010-07-01
申请人： Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
发明人： Eric Bacque , Maurice Brollo , Annie Clauss , Youssef El Ahmad , Bruno Filoche-Romme , Frank Halley , Karl Andreas Karlsson , Gilbert Marciniak , Baptiste Ronan , Laurent Schio , Bertrand Vivet , Fabrice Viviani , Andre Zimmermann
IPC分类号： A61K31/5377 , A61P35/00 , A61P33/02 , A61P3/00 , A61P33/00 , A61P33/06 , C07D487/04 , A61P35/04
CPC分类号： C07D487/04 , A61K31/519 , A61K31/5377 , C07D239/06 , C07D239/42 , C07D413/14
摘要： The invention relates to the novel materials of formula (I), where: R1 is an optionally substituted L-aryl or L-heteroaryl, such that L is a single bond, alkyl, CO, or CO-alk, or L-X, with L□ being an alkyl and X being O or S; R2 is H or alkyl; R3 is an alkyl optionally substituted by Hal; and R4 is Hou Hal, wherein said materials are in any isomeric form and the salts thereof, to be used as drugs.
摘要翻译： 本发明涉及式（I）的新型材料，其中：R1是任选取代的L-芳基或L-杂芳基，使得L是单键，烷基，CO或CO-或LX，与L □为烷基，X为O或S; R2是H或烷基; R3是任选被Hal取代的烷基; 并且R4是Hou Hal，其中所述材料是任何异构形式及其盐，用作药物。
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16.发明授权7-substituted aza-indazoles, compositions containing same, production method and use thereof 有权7-取代的氮杂 - 吲唑，含有它们的组合物，其制备方法和用途公开(公告)号：US08058290B2
公开(公告)日：2011-11-15
申请号：US12021638
申请日：2008-01-29
申请人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
发明人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
IPC分类号： A61K31/44 , C07D491/02
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.
摘要翻译： 本公开涉及式（I）的化合物：其调节蛋白质，特别是激酶的活性，以及其含有该蛋白质的组合物的用途，以及其作为药物，特别是作为抗癌剂的用途。
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17.发明授权Substituted pyrrolopyridines, compositions containing them, manufacturing process therefor and use thereof 失效取代的吡咯并吡啶，含有它们的组合物，其制备方法和用途公开(公告)号：US07947706B2
公开(公告)日：2011-05-24
申请号：US11870640
申请日：2007-10-11
申请人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
发明人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer agents.
摘要翻译： 本发明涉及式（I）化合物：其中R a，R 1，Ar，L，A，W，Y和Z如本公开所定义; 含有它们的组合物; 以及其制备和使用，特别是抗癌剂。
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18.发明授权Substituted indoles, compositions containing them, method for the production thereof and their use 失效取代的吲哚，含有它们的组合物，其制备方法及其用途公开(公告)号：US07566736B2
公开(公告)日：2009-07-28
申请号：US11757613
申请日：2007-06-04
申请人： Frank Halley , Catherine Souaille , Michel Tabart , Eric Bacque , Fabrice Viviani , Baptiste Ronan , Jean-Philippe Letallec , Bruno Filoche-Rommé
发明人： Frank Halley , Catherine Souaille , Michel Tabart , Eric Bacque , Fabrice Viviani , Baptiste Ronan , Jean-Philippe Letallec , Bruno Filoche-Rommé
IPC分类号： A61K31/4045 , C07D209/04
CPC分类号： C07D401/04 , C07D209/42 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04
摘要： Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents.
摘要翻译： 式（I）化合物：其中R 1，R 5，R 6，R 7，Ar，L，A和Q如说明书中所定义，及其盐，含有它们的组合物，其制备方法，以及 其用作药用产品，特别是作为抗癌剂。
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19.发明授权Streptogramin derivatives, preparation method and compositions containing same 有权链球菌素衍生物，制备方法和含有它们的组合物公开(公告)号：US06958383B2
公开(公告)日：2005-10-25
申请号：US10161804
申请日：2002-06-05
申请人： Pascal Desmazeau , Gilles Doerflinger , Yves Ribeill , Eric Bacque , Jean-Claude Barriere , Gilles Dutruc-Rosset , Gérard Puchault
发明人： Pascal Desmazeau , Gilles Doerflinger , Yves Ribeill , Eric Bacque , Jean-Claude Barriere , Gilles Dutruc-Rosset , Gérard Puchault
摘要： Group B streptogramin derivatives of general formula (I): wherein Ra, Rb, Rc, Rd, R1, R2 and Y are as defined in the description, including preparation methods and compositions containing same. Such derivatives are particularly useful as antimicrobial agents, optionally combined with at least one group A streptogramin derivative.
摘要翻译： 通式（I）的B组链霉素衍生物：其中Ra，Rb，Rc，Rd，R 1，R 2和Y如说明书中所定义，包括制备 含有其的方法和组合物。 这样的衍生物特别可用作抗微生物剂，任选地与至少一种A链烷togram啉衍生物组合。
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20.发明授权Quinolylpropylpiperidine derivatives, their preparation, and compositions containing them 失效醌基丙基哌啶衍生物，它们的制备和含有它们的组合物公开(公告)号：US06815547B2
公开(公告)日：2004-11-09
申请号：US10387479
申请日：2003-03-14
申请人： Eric Bacque , Serge Mignani , Jean-Luc Malleron , Michel Tabart , Michel Evers , Fabrice Viviani , Youssef El Ahmad , Stéphane Mutti , Christophe Daubié
发明人： Eric Bacque , Serge Mignani , Jean-Luc Malleron , Michel Tabart , Michel Evers , Fabrice Viviani , Youssef El Ahmad , Stéphane Mutti , Christophe Daubié
IPC分类号： C07D21512
CPC分类号： C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14
摘要： Quinolylpropylpiperidine derivatives of general formula (I) are described, and are useful as antimicrobial agents. Their preparation is also described.
摘要翻译： 描述了通式（I）的喹啉基丙基哌啶衍生物，并且可用作抗微生物剂。 还描述了它们的制备方法。
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