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1.发明申请1,4-Dihydropyridine-Fused Heterocycles, Process for Preparing the Same, Use and Compositions Containing Them 有权1,4-二氢吡啶稠合杂环，其制备方法，含有它们的用途和组合物公开(公告)号：US20080261969A1
公开(公告)日：2008-10-23
申请号：US12014516
申请日：2008-01-15
申请人： Jacques MAUGER , Anil NAIR , Nina MA , Kirsten BJERGARDE , Bruno FILOCHE-ROMME , Odile ANGOUILLANT-BONIFACE , Serge MIGNANI , Jean-Christophe CARRY , Francois CLERC , Herve MINOUX , Laurent SCHIO , Cecile COMBEAU
发明人： Jacques MAUGER , Anil NAIR , Nina MA , Kirsten BJERGARDE , Bruno FILOCHE-ROMME , Odile ANGOUILLANT-BONIFACE , Serge MIGNANI , Jean-Christophe CARRY , Francois CLERC , Herve MINOUX , Laurent SCHIO , Cecile COMBEAU
IPC分类号： A61K31/5377 , C07D471/12 , A61K31/4353 , C07D471/02 , A61P35/00 , A61K31/519 , C07D295/00
CPC分类号： C07D471/04 , C07D471/14
摘要： This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
摘要翻译： 本发明涉及式（I）化合物，其用于制备这些化合物的方法，包含这些化合物的药物组合物，以及涉及治疗方法，包括施用这些化合物。
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2.发明授权Substituted pyrazoles, compositions containing these, method of production and use 有权取代的吡唑，含有这些的组合物，生产和使用方法公开(公告)号：US07989439B2
公开(公告)日：2011-08-02
申请号：US12437618
申请日：2009-05-08
申请人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
发明人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
IPC分类号： A61K31/535
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
摘要翻译： 本公开涉及式（I）的化合物及其盐; 其中Ar，L，A，X，R 1，R 2，R 3，R 4a，R 4b和R 5如本公开所定义; 包含所述化合物的组合物，其制备方法，其中间体及其用途，特别是作为药物。
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3.发明授权Pyrazolopyridine derivatives as inhibitors of β-Adrenergic receptor kinase 1 有权吡唑并吡啶衍生物作为β-肾上腺素能受体激酶1的抑制剂公开(公告)号：US07910602B2
公开(公告)日：2011-03-22
申请号：US11961282
申请日：2007-12-20
申请人： Henning Steinhagen , Jochen Huber , Kurt Ritter , Bernard Pirard , Kirsten Bjergarde , Marcel Patek , Martin Smrcina , Linli Wei
发明人： Henning Steinhagen , Jochen Huber , Kurt Ritter , Bernard Pirard , Kirsten Bjergarde , Marcel Patek , Martin Smrcina , Linli Wei
IPC分类号： A61K31/44 , A01N43/42 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02
CPC分类号： C07D471/04
摘要： The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.
摘要翻译： 本发明涉及可用作β-肾上腺素能受体激酶1抑制剂（＆Bgr; ARK-1）的式（I）的6-酰氨基取代的吡唑并吡啶衍生物，含有这些化合物的组合物及其用于治疗和预防慢性心力衰竭 ，高血压，心肌缺血和丙型肝炎病毒（HCV）感染以及预防鸦片成瘾。
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公开(公告)号：US08420824B2
公开(公告)日：2013-04-16
申请号：US13156947
申请日：2011-06-09
申请人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
发明人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
IPC分类号： C07D401/00
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
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5.发明授权1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them 有权1,4-二氢吡啶稠合的杂环，其制备方法，用途和含有它们的组合物公开(公告)号：US08163768B2
公开(公告)日：2012-04-24
申请号：US12014516
申请日：2008-01-15
申请人： Jacques Mauger , Anil Nair , Nina Ma , Kirsten Bjergarde , Bruno Filoche-Romme , Odile Angouillant-Boniface , Serge Mignani , Jean-Christophe Carry , Francois Clerc , Herve Minoux , Laurent Schio , Cecile Combeau
发明人： Jacques Mauger , Anil Nair , Nina Ma , Kirsten Bjergarde , Bruno Filoche-Romme , Odile Angouillant-Boniface , Serge Mignani , Jean-Christophe Carry , Francois Clerc , Herve Minoux , Laurent Schio , Cecile Combeau
IPC分类号： A61K31/437 , A61K31/4375 , C07D471/14
CPC分类号： C07D471/04 , C07D471/14
摘要： This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
摘要翻译： 本发明涉及式（I）化合物，其用于制备这些化合物的方法，包含这些化合物的药物组合物，以及涉及治疗方法，包括施用这些化合物。
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6.发明申请Pyrazolopyridine derivatives as inhibitors of beta-Adrenergic Receptor Kinase 1 有权吡唑并吡啶衍生物作为β-肾上腺素能受体激酶1的抑制剂公开(公告)号：US20080227777A1
公开(公告)日：2008-09-18
申请号：US11961282
申请日：2007-12-20
申请人： Henning STEINHAGEN , Jochen HUBER , Kurt RITTER , Bernard PIRARD , Kirsten BJERGARDE , Marcel PATEK , Martin SMRCINA , Linli WEI
发明人： Henning STEINHAGEN , Jochen HUBER , Kurt RITTER , Bernard PIRARD , Kirsten BJERGARDE , Marcel PATEK , Martin SMRCINA , Linli WEI
IPC分类号： A61K31/5377 , C07D471/04 , A61P31/12 , A61P25/36 , A61K31/437
CPC分类号： C07D471/04
摘要： The invention relates to 6-amido substituted pyrazolopyridine derivatives of the formula (I) useful as inhibitors of beta-adrenergic receptor kinase 1 (βARK-1), compositions containing such compounds and their use for the treatment and prevention of chronic heart failure, hypertension, myocardial ischemia and hepatitis C virus (HCV) infections, and for the prevention of opiate addiction.
摘要翻译： 本发明涉及可用作β-肾上腺素能受体激酶1（βARK-1）抑制剂的式（I）的6-酰氨基取代的吡唑并吡啶衍生物，含有这些化合物的组合物及其用于治疗和预防慢性心力衰竭，高血压的用途 ，心肌缺血和丙型肝炎病毒（HCV）感染，以及预防鸦片成瘾。
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7.发明授权Substituted pyrazoles, compositions containing these, method of production and use 失效取代的吡唑，含有这些的组合物，生产和使用方法公开(公告)号：US08410286B2
公开(公告)日：2013-04-02
申请号：US13156915
申请日：2011-06-09
申请人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
发明人： Kirsten Bjergarde , Mark Dodson , Jacques Mauger , Anil Nair , Marcel Patek , Michel Tabart
IPC分类号： C07D231/10 , C07D231/12
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
摘要翻译： 本公开涉及式（I）的化合物及其盐; 其中Ar，L，A，X，R 1，R 2，R 3，R 4a，R 4b和R 5如本公开所定义; 包含所述化合物的组合物，其制备方法，其中间体及其用途，特别是作为药物。
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8.发明授权7-substituted aza-indazoles, compositions containing same, production method and use thereof 有权7-取代的氮杂 - 吲唑，含有它们的组合物，其制备方法和用途公开(公告)号：US08058290B2
公开(公告)日：2011-11-15
申请号：US12021638
申请日：2008-01-29
申请人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
发明人： Kirsten Bjergarde , Anil Nair , Marcel Patek , Martha Ackerman-Berrier , Martin Smrcina , Eric Bacque , Michel Tabart , Baptiste Ronan , Vincent Leroy , Fabrice Viviani , Mark Dodson , Catherine Souaille
IPC分类号： A61K31/44 , C07D491/02
CPC分类号： C07D471/04
摘要： The disclosure relates to compounds of formula (I): which modulate the activity of proteins, particularly kinases, and to compositions containing the same, and to the use thereof as medicaments, in particular as anticancer agents.
摘要翻译： 本公开涉及式（I）的化合物：其调节蛋白质，特别是激酶的活性，以及其含有该蛋白质的组合物的用途，以及其作为药物，特别是作为抗癌剂的用途。
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公开(公告)号：US20110237801A1
公开(公告)日：2011-09-29
申请号：US13156947
申请日：2011-06-09
申请人： Kirsten BJERGARDE , Mark DODSON , Jacques MAUGER , Anil NAIR , Marcel PATEK , Michel TABART
发明人： Kirsten BJERGARDE , Mark DODSON , Jacques MAUGER , Anil NAIR , Marcel PATEK , Michel TABART
IPC分类号： C07D401/12 , C07D231/38 , C07F7/10
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
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10.发明申请SUBSTITUTED PYRAZOLES, COMPOSITIONS CONTAINING THESE, METHOD OF PRODUCTION AND USE 失效取代的吡唑，包含这些的组合物，生产和使用方法公开(公告)号：US20110237641A1
公开(公告)日：2011-09-29
申请号：US13156915
申请日：2011-06-09
申请人： Kirsten BJERGARDE , Mark DODSON , Jacques MAUGER , Anil NAIR , Marcel PATEK , Michel TABART
发明人： Kirsten BJERGARDE , Mark DODSON , Jacques MAUGER , Anil NAIR , Marcel PATEK , Michel TABART
IPC分类号： A61K31/415 , C07D231/38 , C12N9/99 , A61P35/00
CPC分类号： C07C273/18 , C07D231/38 , C07C275/38
摘要： The disclosure relates to a compound of formula (I): and salts thereof; wherein Ar, L, A, X, R1, R2, R3, R4a, R4b, and R5 are as defined in the disclosure; compositions comprising said compounds, methods for their preparation, intermediates thereto, and the use thereof, particularly as drugs.
摘要翻译： 本公开涉及式（I）的化合物及其盐; 其中Ar，L，A，X，R 1，R 2，R 3，R 4a，R 4b和R 5如本公开所定义; 包含所述化合物的组合物，其制备方法，其中间体及其用途，特别是作为药物。
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