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23 条记录 (耗时 0.051 秒)

    Catheter with spiral cut transition member
    11.
    发明申请
    Catheter with spiral cut transition member 有权
    导管与螺旋切割过渡构件

    公开(公告)号：US20070005009A1

    公开(公告)日：2007-01-04

    申请号：US11516062

    申请日：2006-09-06

    申请人： Christopher Larson ,  Angela Volk

    发明人： Christopher Larson ,  Angela Volk

    IPC分类号： A61M25/00

    CPC分类号： A61M25/104 ,  A61M25/0054 ,  A61M25/1006 ,  A61M2025/0063 ,  A61M2025/0081 ,  A61M2025/0098

    摘要： A tubular transition member having an annular wall with at least one cut extending through the annular wall is disclosed for controlling a transition in stiffness of a catheter from a stiffer more pushable proximal section to a more flexible and trackable distal section and increasing kink resistance. The transition member may extend across the junction formed between the stiffer proximal section and the more flexible distal section. The transition member may be used in conjunction with any type of catheter including single-operator-exchange type catheters, over-the wire type catheters, and/or fixed-wire type catheters.

    摘要翻译： 公开了一种具有环形壁的管状过渡构件，其具有延伸穿过环形壁的至少一个切口，用于控制导管刚性从较刚性更可推的近端区段向更柔性和可跟踪的远侧区段的过渡，并增加扭结阻力。 过渡构件可以延伸穿过更硬的近端部分和更柔性的远端部分之间形成的连接点。 过渡构件可以与任何类型的导管结合使用，包括单一操作者交换型导管，线型导管和/或固定线型导管。

    Electro-acoustic transducer
    14.
    发明申请
    Electro-acoustic transducer 失效
    电声换能器

    公开(公告)号：US20050201586A1

    公开(公告)日：2005-09-15

    申请号：US10798529

    申请日：2004-03-10

    申请人： Dean Rivera ,  Christopher Larson

    发明人： Dean Rivera ,  Christopher Larson

    IPC分类号： H04R1/00 ,  H04R9/06 ,  H04R11/02 ,  H04R25/00

    CPC分类号： H04R1/021

    摘要： An electro-acoustic transducer for driving a large surface is used to convert electrical signals into sound. The transducer has a housing with a cast aluminum bottom and a molded plastic top. The top and bottom are fastened together by screws with a gasket in between the contacting surfaces to form a housing for a high power electromagnetic voice coil driver mechanism. The top has an opening to allow the voice coil to be centered in its gap by a centering gauge during assembly of the driver. A cap closes the opening once the voice coil is fixed in place in the housing. The op is hexagonal and flat with circular rings in the top surface to allow the top to flex in a controlled manner while supporting the bottom which remains stationary.

    摘要翻译： 用于驱动大表面的电声换能器用于将电信号转换为声音。 传感器具有带有铸铝底部和模制塑料顶部的壳体。 顶部和底部通过具有垫圈的螺钉紧固在接触表面之间，以形成用于高功率电磁音圈驱动器机构的壳体。 顶部具有开口，以允许音圈在驱动器的组装期间通过定心计在其间隙中心。 一旦音圈被固定在外壳中的适当位置，盖子会关闭开口。 op是六边形并且平坦的，在顶部表面中具有圆形环，以允许顶部以受控的方式弯曲，同时支撑保持静止的底部。

    Method for determining articular bone deformity resection using motion patterns
    15.
    发明授权
    Method for determining articular bone deformity resection using motion patterns 有权
    使用运动模式确定关节骨畸形切除的方法

    公开(公告)号：US09122670B2

    公开(公告)日：2015-09-01

    申请号：US13704063

    申请日：2011-06-16

    申请人： Laurence Chabanas ,  Stéphane Lavallee ,  Jerome Tonetti ,  Thomas Byrd ,  Bryan Talmadge Kelly ,  Christopher Larson

    发明人： Laurence Chabanas ,  Stéphane Lavallee ,  Jerome Tonetti ,  Thomas Byrd ,  Bryan Talmadge Kelly ,  Christopher Larson

    IPC分类号： G06F17/50 ,  G06F19/26 ,  G06T17/00 ,  G06T19/20

    CPC分类号： G06F19/26 ,  G06T17/00 ,  G06T19/20 ,  G06T2210/21 ,  G06T2210/41 ,  G06T2219/2021

    摘要： The invention relates to a method for real-time determination an optimal corrected surface of a first bone and/or a second bone forming together an articulation, the first and/or second bones presenting an overgrowth deformation, said corrected surface providing a greater range of motion of the articulation, the method comprising the following steps: i) constructing from acquired images of the articulation 3D voxel models of the first bone and the second bone; ii) for each of first and second bone voxel models, constructing a coordinate system defined by a center and three axes; iii) applying a motion pattern on the coordinate system of the second bone with respect to the coordinate system of the first bone, a motion pattern being a set of contiguous positions of the first or second bone coordinate systems with respect to the other bone coordinate system, the contiguous positions defining a movement of one bone with respect to the other, wherein said motion pattern is initially loaded from a data base of predefined motion patterns; iv) determining a resection volume from said motion pattern as being the union of interpenetration volumes of the first or second bone voxel model with the other bone voxel model for each position of the motion pattern; v) determining the optimal corrected surface by virtually removing said resection volume from the first and/or the second bone voxel model.

    摘要翻译： 本发明涉及一种用于实时确定第一骨骼和/或第二骨骼的最佳校正表面的方法，所述第一骨骼和/或第二骨骼一起形成关节，第一和/或第二骨骼呈现过度生长变形，所述校正表面提供更大范围的 所述方法包括以下步骤：i）从所述第一骨骼和所述第二骨骼的关节3D体素模型的获取图像构建; ii）对于第一和第二骨骼体素模型中的每一个，构造由中心和三个轴限定的坐标系; iii）相对于第一骨骼的坐标系在第二骨骼的坐标系上施加运动模式，运动模式是第一或第二骨坐标系相对于另一骨坐标系的一组连续位置 所述邻接位置限定一个骨骼相对于另一个的运动，其中所述运动模式最初从预定的运动模式的数据库加载; iv）将所述运动模式的切除体积确定为所述运动模式的每个位置的所述第一或第二骨骼体素模型与所述另一骨体素模型的相互渗透体积的联合; v）通过从第一和/或第二骨骼体素模型中虚拟去除所述切除体积来确定最佳校正表面。

    Methods of using and analyzing biological sequence data
    16.
    发明申请
    Methods of using and analyzing biological sequence data 审中-公开
    使用和分析生物序列数据的方法

    公开(公告)号：US20070212700A1

    公开(公告)日：2007-09-13

    申请号：US11518590

    申请日：2006-09-07

    申请人： Rama Ranganathan ,  William Russ ,  Christopher Larson ,  Rohit Sharma

    发明人： Rama Ranganathan ,  William Russ ,  Christopher Larson ,  Rohit Sharma

    IPC分类号： C12Q1/68 ,  G06F19/00

    CPC分类号： G16B30/00 ,  G16B20/00 ,  G16B40/00

    摘要： Methods of using biological sequence data. Evolved biological sequences may be used to identify the defining biological characteristics of the sequences—the three-dimensional structure and biochemical function. Some of the present methods extract such information, use such information to predict functional mechanism, and/or use such information in the design of artificial biological sequences. Other methods are included, as are related computer readable media and computer systems.

    摘要翻译： 使用生物序列数据的方法。 演化的生物学序列可用于鉴定序列的定义生物学特征 - 三维结构和生物化学功能。 本方法中的一些提取这些信息，使用这样的信息来预测功能机制，和/或在设计人造生物序列时使用这些信息。 还包括其他方法，以及相关的计算机可读介质和计算机系统。

    Process for preparing a non-conductive substrate for electroplating
    17.
    发明授权
    Process for preparing a non-conductive substrate for electroplating 失效
    制备用于电镀的非导电基底的方法

    公开(公告)号：US5674372A

    公开(公告)日：1997-10-07

    申请号：US710977

    申请日：1996-09-24

    申请人： Peter Kukanskis ,  Kathleen Yocis ,  Christopher Larson

    发明人： Peter Kukanskis ,  Kathleen Yocis ,  Christopher Larson

    IPC分类号： C25D5/54 ,  H05K3/42 ,  C25D5/02

    CPC分类号： H05K3/424 ,  C25D5/54 ,  H05K3/427

    摘要： A process is disclosed for the direct electroplating of a non-conductive material comprising non-conductive surfaces and metallic surfaces. The process involves contacting the non-conductive material with a compound capable of selectively forming a sacrificial layer on the metallic surfaces which sacrificial layer is substantially insoluble in alkaline or neutral media but soluble in acidic media. The foregoing step is followed by deposition of carbon onto the surfaces followed by contact with an acidic solution and subsequent electroplating.

    摘要翻译： 公开了一种用于直接电镀包括非导电表面和金属表面的非导电材料的方法。 该方法包括使非导电材料与能够在金属表面上选择性地形成牺牲层的化合物接触，该牺牲层基本上不溶于碱性或中性介质，但可溶于酸性介质。 上述步骤之后是将碳沉积在表面上，然后与酸性溶液接触并随后进行电镀。

    Method for determining bone resection on a deformed bone surface from few parameters
    18.
    发明授权
    Method for determining bone resection on a deformed bone surface from few parameters 有权
    从几个参数确定变形骨表面的骨切除方法

    公开(公告)号：US09020223B2

    公开(公告)日：2015-04-28

    申请号：US13704510

    申请日：2011-06-16

    申请人： Laurence Chabanas ,  Stéphane Lavallee ,  Jerome Tonetti ,  Thomas Byrd ,  Bryan Talmadge Kelly ,  Christopher Larson

    发明人： Laurence Chabanas ,  Stéphane Lavallee ,  Jerome Tonetti ,  Thomas Byrd ,  Bryan Talmadge Kelly ,  Christopher Larson

    IPC分类号： G06K9/00 ,  G06T7/00 ,  G06T17/30 ,  G06T19/20

    CPC分类号： G06T7/0012 ,  G06T3/60 ,  G06T5/002 ,  G06T17/30 ,  G06T19/20 ,  G06T2210/41 ,  G06T2219/2021

    摘要： The invention relates to a method for non-invasive reproducible determination of a corrected surface on a 3D bone surface model constructed from 3D medical image of a bone having a deformation consisting in a bump overgrowth at the head-neck junction; wherein said corrected surface comprises: i) a 3D spherical corrected surface patch on the head portion of said 3D bone surface model, and ii) a 3D smooth transition corrected surface patch on the neck portion of said 3D bone surface model, contiguous to said 3D spherical corrected surface patch; Said corrected surface patches are defined by a set of parameters comprising: iii) at least one first parameter (a*) representing a spherical extent value of said 3D spherical corrected surface patch, iv) and a set of at least one second parameter, said set determining the 3D correction boundary of said corrected surface patches, such that said corrected surface patches are continuous with said 3D bone surface model along said boundary.

    摘要翻译： 本发明涉及一种用于在由具有由头颈交界处的隆起过度生长组成的变形的骨的3D医学图像构建的3D骨表面模型上进行的非侵入式可重复确定校正表面的方法; 其中所述校正表面包括：i）所述3D骨表面模型的头部上的3D球面校正表面贴片，以及ii）所述3D骨表面模型的颈部上的3D平滑过渡校正表面贴片，其与所述3D骨表面模型相邻 球面校正面贴片; 所述修正的表面贴片由一组参数定义，包括：iii）表示所述3D球面校正表面贴片的球面范围值的至少一个第一参数（a *），iv）和至少一个第二参数的集合，所述 设置确定所述校正的表面贴片的3D校正边界，使得所述校正的表面贴片沿着所述边界与所述3D骨表面模型连续。

    Analysis of circulating tumor cells, fragments, and debris
    20.
    发明授权
    Analysis of circulating tumor cells, fragments, and debris 有权
    分析循环肿瘤细胞，碎片和碎片

    公开(公告)号：US08329422B2

    公开(公告)日：2012-12-11

    申请号：US12917630

    申请日：2010-11-02

    申请人： Galla Chandra Rao ,  Christopher Larson ,  Madeline Repollet ,  Herman Rutner ,  Leon W. M. M. Terstappen ,  Shawn Mark O'Hara ,  Steven Gross

    发明人： Galla Chandra Rao ,  Christopher Larson ,  Madeline Repollet ,  Herman Rutner ,  Leon W. M. M. Terstappen ,  Shawn Mark O'Hara ,  Steven Gross

    IPC分类号： G01N33/574 ,  G01N33/553 ,  G01N1/18

    CPC分类号： G01N33/574 ,  G01N33/54326 ,  Y10S436/813 ,  Y10T436/101666 ,  Y10T436/25125 ,  Y10T436/25375

    摘要： The methods and reagents described in this invention are used to analyze circulating tumor cells, clusters, fragments, and debris. Analysis is performed with a number of platforms, including flow cytometry and the CELLSPOTTER® fluorescent microscopy imaging system. Analyzing damaged cells has shown to be important. However, there are two sources of damage: in vivo and in vitro. Damage in vivo occurs by apoptosis, necrosis, or immune response. Damage in vitro occurs during sample acquisition, handling, transport, processing, or analysis. It is therefore desirable to confine, reduce, eliminate, or at least qualify in vitro damage to prevent it from interfering in analysis. Described herein are methods to diagnose, monitor, and screen disease based on circulating rare cells, including malignancy as determined by CTC, clusters, fragments, and debris. Also provided are kits for assaying biological specimens using these methods.

    摘要翻译： 本发明描述的方法和试剂用于分析循环肿瘤细胞，簇，碎片和碎片。 使用许多平台进行分析，包括流式细胞术和CELLSPOTTER®荧光显微镜成像系统。 分析损伤的细胞已被证明是重要的。 然而，有两个损害来源：体内和体外。 体内损伤是通过细胞凋亡，坏死或免疫应答发生的。 在样品采集，处理，运输，加工或分析过程中发生体外损伤。 因此，期望限制，减少，消除或至少限定体外损伤，以防止其干扰分析。 本文描述了基于循环稀有细胞（包括由CTC，簇，碎片和碎片确定的恶性肿瘤）来诊断，监测和筛选疾病的方法。 还提供了使用这些方法测定生物样品的试剂盒。