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    Biocompatible polycaprolactone fumarate formulations
    11.
    发明授权
    Biocompatible polycaprolactone fumarate formulations 有权

    公开(公告)号：US10426867B2

    公开(公告)日：2019-10-01

    申请号：US14009987

    申请日：2012-04-04

    申请人： Michael Brett Runge ,  Michael J. Yaszemski

    发明人： Michael Brett Runge ,  Michael J. Yaszemski

    IPC分类号： A61L27/18 ,  A61L27/26 ,  C08G63/08 ,  C08G63/60

    摘要： A polycaprolactone fumarate polymer useful as a matrix material for a biocompatible scaffold for tissue engineering applications is disclosed. The polycaprolactone fumarate polymer can be prepared by reacting caprolactone with an alkane polyol to prepare a polycaprolactone precursor, and then reacting the polycaprolactone precursor with fumaric acid or a salt thereof to prepare the polycaprolactone fumarate polymer. The use of an alkane diol, such as 1,2-propanediol, provides a linear polycaprolactone diol precursor. The use of an alkane triol, such as glycerol, provides a branched polycaprolactone triol precursor. The biocompatible polycaprolactone fumarate formulation releases no diethylene glycol or other undesirable byproducts during degradation.

    SPINAL ORTHOSES
    12.
    发明申请
    SPINAL ORTHOSES 审中-公开
    脊柱畸形

    公开(公告)号：US20090054818A1

    公开(公告)日：2009-02-26

    申请号：US11628996

    申请日：2005-06-09

    申请人： Kenton R. Kaufman ,  Michael J. Yaszemski

    发明人： Kenton R. Kaufman ,  Michael J. Yaszemski

    IPC分类号： A61F5/00

    CPC分类号： A61F5/34 ,  A61F5/012 ,  A61F5/022 ,  A61F5/024

    摘要： A thoracolumbosacral and a lumbosacral orthosis with sagittal-coronal control are disclosed. The orthoses have two rigid anterior and posterior plastic shells. The anterior shell extends from the pelvis to the sternum. The posterior shell extends from the pelvis and terminates just inferior to the scapular spine. An interior surface of the anterior shell has pressure pads that apply pressure to locations on the patient's anterior torso and the interior surface of the posterior shell has pressure pads that apply pressure to locations on the patient's posterior torso when the anterior shell and the posterior shell are secured to the patient's torso. The pressure pads may be inflatable air bladders.

    摘要翻译： 公开了一种具有矢状冠状动脉控制的胸腰椎和腰骶矫形器。 矫形器有两个刚性的前后塑料外壳。 前囊从骨盆延伸到胸骨。 后壳从骨盆延伸，终止于肩胛骨下方。 前壳的内表面具有对患者前躯干上的位置施加压力的压力垫，并且后壳的内表面具有压力垫，当前壳和后壳是前壳和后壳时，压力垫对患者的后躯体上的位置施加压力 固定在患者的躯干上。 压垫可以是可充气的气囊。

    Poly(propylene fumarate)
    13.
    发明授权
    Poly(propylene fumarate) 失效
    聚（富马酸丙烯酯）

    公开(公告)号：US5733951A

    公开(公告)日：1998-03-31

    申请号：US234551

    申请日：1994-04-28

    申请人： Michael J. Yaszemski ,  Richard G. Payne ,  Antonios G. Mikos

    发明人： Michael J. Yaszemski ,  Richard G. Payne ,  Antonios G. Mikos

    IPC分类号： A61L24/04 ,  C08G63/52 ,  C08G63/02 ,  A61F2/00 ,  C08K3/32

    CPC分类号： C08G63/52 ,  A61L24/046

    摘要： A novel pathway for the synthesis of poly(propylene fumarate) includes first producing bis-hydroxypropyl fumarate and then its transesterification into poly(propylene fumarate). This synthetic pathway permits production of high molecular weight poly(propylene fumarate) and enables the production of a composite material useful in orthopedic procedures.

    摘要翻译： 用于合成聚（富马酸丙烯酯）的新途径包括首先生产富马酸双羟丙酯，然后将其酯交换成聚（富马酸丙烯酯）。 该合成途径允许生产高分子量聚（富马酸丙烯酯），并且能够生产用于矫形程序的复合材料。

    Photodegradable polycaprolactone fumarate block copolymers
    15.
    发明授权
    Photodegradable polycaprolactone fumarate block copolymers 有权

    公开(公告)号：US10568985B2

    公开(公告)日：2020-02-25

    申请号：US13955279

    申请日：2013-07-31

    申请人： Michael Brett Runge ,  Michael J. Yaszemski

    发明人： Michael Brett Runge ,  Michael J. Yaszemski

    IPC分类号： A61L27/18 ,  C08L67/04 ,  C08G63/08 ,  A61L27/56

    摘要： A polycaprolactone fumarate copolymer useful as a material for a biocompatible scaffold for tissue engineering applications is disclosed. The copolymer includes at least one caprolactone unit, at least one fumarate unit, and at least one third unit selected from the group consisting of acrylate units and styrenic units. A linking moiety forms a link between the third unit and at least one caprolactone unit or at least one fumarate unit. The linking moiety can be photodegradable. In one form, the third unit includes at least one methyl methacrylate unit. The copolymer can be used to form the wall of a nerve conduit.

    Bone replacement compound comprising poly(polypropylene fumarate)
    16.
    发明授权
    Bone replacement compound comprising poly(polypropylene fumarate) 有权
    包含聚（聚丙烯富马酸酯）的骨替代化合物

    公开(公告)号：US6124373A

    公开(公告)日：2000-09-26

    申请号：US289361

    申请日：1999-04-09

    申请人： Susan J. Peter ,  Michael J. Yaszemski ,  Antonios G. Mikos

    发明人： Susan J. Peter ,  Michael J. Yaszemski ,  Antonios G. Mikos

    IPC分类号： A61L27/00 ,  A61L24/00 ,  A61L24/04 ,  A61L27/18 ,  C08G63/52 ,  C08G63/56 ,  C08G63/78 ,  C08K3/32 ,  C08L67/06

    CPC分类号： C08G63/56 ,  A61L24/0084 ,  A61L24/046 ,  A61L27/18 ,  C08G63/52

    摘要： A method for controlling the gel point of a bone cement containing poly(polypropylene fumarate), a cross-linking monomer, an initiator, an inorganic filler, and a radical initiator. The gel point is controlled by varying the molecular weight of the poly(polypropylene fumarate) while maintaining the weight average molecular weight (M.sub.w) of the poly(polypropylene fumarate) above 2000 and the polydispersity index of the poly(polypropylene fumarate) below 2. In a preferred embodiment, the molecular weight of the poly(polypropylene fumarate) greater than 4000, and more preferably greater than 5000.

    摘要翻译： 一种控制含有聚（聚丙烯富马酸盐），交联单体，引发剂，无机填料和自由基引发剂的骨水泥凝胶点的方法。 凝胶点通过改变聚（聚丙烯富马酸酯）的分子量来控制，同时保持聚（聚丙烯富马酸酯）的重均分子量（Mw）大于2000，聚（聚丙烯·富马酸酯）的多分散指数低于2。 在优选的实施方案中，聚（聚丙烯富马酸盐）的分子量大于4000，更优选大于5000。

    Photodegradable Polycaprolactone Fumarate Block Copolymers
    17.
    发明申请
    Photodegradable Polycaprolactone Fumarate Block Copolymers 审中-公开
    可降解聚己内酯富马酸酯嵌段共聚物

    公开(公告)号：US20140039075A1

    公开(公告)日：2014-02-06

    申请号：US13955279

    申请日：2013-07-31

    申请人： Michael Brett Runge ,  Michael J. Yaszemski

    发明人： Michael Brett Runge ,  Michael J. Yaszemski

    IPC分类号： A61L27/18

    摘要： A polycaprolactone fumarate copolymer useful as a material for a biocompatible scaffold for tissue engineering applications is disclosed. The copolymer includes at least one caprolactone unit, at least one fumarate unit, and at least one third unit selected from the group consisting of acrylate units and styrenic units. A linking moiety forms a link between the third unit and at least one caprolactone unit or at least one fumarate unit. The linking moiety can be photodegradable. In one form, the third unit includes at least one methyl methacrylate unit. The copolymer can be used to form the wall of a nerve conduit.

    摘要翻译： 公开了可用作组织工程应用的生物相容性支架材料的聚己内酯富马酸共聚物。 共聚物包括至少一种己内酯单元，至少一种富马酸酯单元和至少一种选自丙烯酸酯单元和苯乙烯单元的第三单元。 连接部分形成第三单元与至少一个己内酯单元或至少一个富马酸酯单元之间的连接。 连接部分可以是光降解的。 在一种形式中，第三单元包括至少一种甲基丙烯酸甲酯单元。 共聚物可用于形成神经管道的壁。

    Spinal cord surgical implant
    18.
    发明授权
    Spinal cord surgical implant 有权
    脊髓手术植入物

    公开(公告)号：US07163545B2

    公开(公告)日：2007-01-16

    申请号：US10629427

    申请日：2003-07-29

    申请人： Michael J. Yaszemski ,  Jonathan A. Friedman ,  Michael J. Moore ,  Anthony J. Windebank

    发明人： Michael J. Yaszemski ,  Jonathan A. Friedman ,  Michael J. Moore ,  Anthony J. Windebank

    IPC分类号： A61B17/08

    CPC分类号： A61B17/08 ,  A61B17/1128 ,  A61L27/383 ,  A61L27/3878 ,  A61L27/58 ,  A61L31/005 ,  A61L31/148 ,  A61L2430/32

    摘要： An implant for bridging a gap in a severed spinal cord or nerve and for promoting nerve regeneration has a matrix comprising a biocompatible, biodegradable, polymeric material. The matrix has a proximal end for connection to a first end of severed spinal cord and a distal end for connection to a second end of severed spinal cord. The matrix includes internal guidance channels extending between the proximal end and the distal end to facilitate rejoining of the first end and the second end of the severed spinal cord. A bioactive agent may be dispersed in the matrix, or disposed in the channels, or included within microspheres in the channels. The channels may be arranged such that guidance channels correspond to spinal cord tracts. Alternatively, guidance channels may be spaced apart at the proximal end of the matrix and converge inward toward the axis of the matrix at the distal end.

    摘要翻译： 用于桥接切断的脊髓或神经中的间隙并用于促进神经再生的植入物具有包含生物相容性，可生物降解的聚合材料的基质。 基质具有用于连接到切断的脊髓的第一端的近端和用于连接到切断的脊髓的第二端的远端。 基体包括在近端和远端之间延伸的内部引导通道，以便于重新连接切断的脊髓的第一端和第二端。 生物活性剂可以分散在基质中，或者设置在通道中，或者包含在通道中的微球体内。 通道可以布置成使得引导通道对应于脊髓束。 或者，引导通道可以在基体的近端处间隔开并且在远端处朝向矩阵的轴线向内收敛。