公开(公告)号：US20150174287A1

公开(公告)日：2015-06-25

申请号：US14635170

申请日：2015-03-02

Applicant: Ethicon, Inc.

Inventor： Daniel Steiger ,  Dennis D. Jamiolkowski ,  Modesto Erneta

IPC: A61L17/12 ,  B29C49/00 ,  B29C47/00 ,  C08J3/00 ,  B29C45/00

CPC classification number: A61L17/12 ,  A61B17/06166 ,  A61B17/064 ,  A61B2017/00004 ,  A61L17/005 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/202 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2430/00 ,  B29C45/00 ,  B29C47/00 ,  B29C49/00 ,  B29L2031/753 ,  C08J3/005 ,  C08J2367/04 ,  C08J2467/04 ,  C08L67/04 ,  Y10T442/10 ,  Y10T442/3976 ,  Y10T442/40 ,  Y10T442/696

Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.

Abstract translation: 公开了新颖的可吸收聚合物共混物。 该混合物可用于制造具有工程化降解和体内断裂强度保留的医疗装置。 共混物由第一可吸收聚合物组分和第二可吸收聚合物组分组成。 第一聚合物组分的重均分子量高于第二聚合物组分的重均分子量。 所述组分中的至少一种至少部分被羧酸基部分封端。 其他方面是由其制成的医疗装置。

公开(公告)号：US20140275467A1

公开(公告)日：2014-09-18

申请号：US14195220

申请日：2014-03-03

Applicant: Ethicon, Inc.

Inventor： Dennis D. Jamiolkowski ,  Modesto Erneta ,  Terry E. Lawler ,  Rao S. Bezwada

IPC: A61L17/10 ,  A61L31/06

CPC classification number: A61L17/105 ,  A61B17/06166 ,  A61B17/064 ,  A61B17/122 ,  A61B2017/00004 ,  A61B2017/00526 ,  A61L17/12 ,  A61L31/06 ,  A61L31/148 ,  C08G63/08 ,  C08G63/823 ,  C08L67/04

Abstract: The present invention is directed to a novel polymerization process for making novel absorbable, linear polylactone polymers prepared using novel polymerization initiators to achieve rates of mechanical property loss or of absorption of articles made from the polymers that are at least about 1.2 times faster than the rates of mechanical property loss of polymers made by similar processes utilizing conventional initiators. The novel polymerization initiators include monols or diols possessing at least one primary alcohol group and two or more carboxylic acid groups. The invention also is directed to absorbable polylactone polymers prepared by processes of the present invention and to medical devices made from such polymers.

Abstract translation: 本发明涉及一种新颖的聚合方法，用于制备新的可吸收的线性聚内酯聚合物，其使用新的聚合引发剂制备，以获得由聚合物制成的制品的机械性能损失或吸收速率，其速率比速率高至少约1.2倍 的通过使用常规引发剂的类似方法制备的聚合物的机械性能损失。 新型聚合引发剂包括具有至少一个伯醇基团和两个或更多个羧酸基团的单醇或二醇。 本发明还涉及通过本发明的方法制备的可吸收的聚内酯聚合物和由这样的聚合物制成的医疗装置。

公开(公告)号：US08552142B2

公开(公告)日：2013-10-08

申请号：US13630062

申请日：2012-09-28

Applicant: Ethicon, Inc.

Inventor： Modesto Erneta ,  Dennis D. Jamiolkowski ,  Jianguo J. Zhou ,  Sasa Andjelic

IPC: C08G63/08

CPC classification number: C08G63/08 ,  B29C47/0014 ,  B29C47/385 ,  B29C47/6087 ,  B29C47/889 ,  B29C2947/92514 ,  B29C2947/9259 ,  B29C2947/92704 ,  B29C2947/92885 ,  B29C2947/92895 ,  B29C2947/92904 ,  D04H1/56 ,  D04H3/02 ,  D04H3/16 ,  Y10T442/68

Abstract: Copolymers exhibiting the following combinations of properties, including without limitation, ε-caprolactone in an amount ranging from about 12 to about 70 mole percent, glycolide in an amount ranging from about 30 to about 88 mole percent, crystallinity ranging from about 10 to about 50% as measured by WAXD or about 10 to about 50 J/g as measured by DSC, and an inherent viscosity ranging from about 0.5 to about 1.45 dL/g as measured in a 0.1 g/dl solution of HFIP at 25° C.; a method for melt blowing such copolymers and nonwoven constructs produced therefrom are described herein.

Abstract translation: 表现出以下组合性质的共聚物，包括但不限于ε-己内酯，其量为约12至约70摩尔％，乙交酯的量为约30至约88摩尔％，结晶度为约10至约50 ％，通过DSC测量为约10至约50J / g，并且在25℃下在0.1g / dl HFIP溶液中测量的特性粘度范围为约0.5至约1.45dL / g。 本文描述了熔融吹制由此产生的共聚物和非织造构造物的方法。