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公开(公告)号：US20210322624A1
公开(公告)日：2021-10-21
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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2.发明申请公开(公告)号：US20200000958A1
公开(公告)日：2020-01-02
申请号：US16021322
申请日：2018-06-28
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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公开(公告)号：US09737630B2
公开(公告)日：2017-08-22
申请号：US14635215
申请日：2015-03-02
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Modesto Erneta
IPC: A61L17/12 , A61L27/26 , A61L27/54 , A61B17/064 , B29C45/00 , B29C47/00 , B29C49/00 , C08L67/04 , A61L17/00 , A61B17/06 , C08J3/00 , A61B17/00 , B29L31/00
CPC classification number: A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
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4.发明申请ABSORBABLE POLYMERIC BLEND COMPOSITIONS BASED ON COPOLYMERS PREPARED FROM MONO- AND DI-FUNCTIONAL POLYMERIZATION INITIATORS, PROCESSING METHODS, AND MEDICAL DEVICES THEREFROM 有权基于单功能和二功能聚合引发剂制备的共聚物的可吸收的聚合物组合物，其加工方法及其医疗设备公开(公告)号：US20150165096A1
公开(公告)日：2015-06-18
申请号：US14571371
申请日：2014-12-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
CPC classification number: A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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公开(公告)号：US11596709B2
公开(公告)日：2023-03-07
申请号：US17349535
申请日：2021-06-16
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Christopher DeFelice , Sasa Andjelic , Brian M. Kelly , Marc Wisnudel , Daniel Steiger , Gaoyuan Gavin Chen
Abstract: Novel surgical sutures and novel medical devices made from novel semi-crystalline, glycolide-rich A-B-A triblock copolymers of glycolide and lactide, wherein said B-segment is a fully amorphous random copolymer of glycolide and lactide, for long term medical applications are disclosed. The novel polymer compositions are useful for long term absorbable surgical sutures, meshes and other medical devices, especially for patients with compromised healing. The novel sutures have improved properties and improved breaking strength retention, while still substantially absorbing within about a 120-day period post-implantation.
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Patent Agency Ranking
公开(公告)号：US10058637B2
公开(公告)日：2018-08-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
IPC: A61L27/26 , A61L27/58 , C08L67/04 , A61L31/04 , A61L31/14 , A61B17/064 , A61L17/10 , A61B17/06 , A61B17/00
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
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7.发明申请公开(公告)号：US20150174288A1
公开(公告)日：2015-06-25
申请号：US14635215
申请日：2015-03-02
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Modesto Erneta
CPC classification number: A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 该混合物可用于制造具有工程化降解和体内断裂强度保留的医疗装置。 共混物由第一可吸收聚合物组分和第二可吸收聚合物组分组成。 第一聚合物组分的重均分子量高于第二聚合物组分的重均分子量。 所述组分中的至少一种至少部分被羧酸基部分封端。 其他方面是由其制成的医疗装置。
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8.发明申请Absorbable Polymeric Blend Compositions with Precisely Controllable Absorption Rates, Processing Methods, and Dimensionally Stable Medical Devices Therefrom 审中-公开可吸收的具有精确控制吸收率的聚合物混合组合物，加工方法和尺寸稳定的医疗器械公开(公告)号：US20150148496A1
公开(公告)日：2015-05-28
申请号：US14548536
申请日：2014-11-20
Applicant: Ethicon, Inc.
Inventor： Dennis D. Jamiolkowski , Daniel Steiger , Brian M. Kelly , Christopher DeFelice , Sasa Andjelic , Modesto Erneta
CPC classification number: A61L31/041 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/105 , A61L27/26 , A61L27/58 , A61L31/148 , C08L67/04 , C08L2205/03 , C08L2666/18
Abstract: Novel absorbable polymeric blends are disclosed. The blends have a first absorbable polymer type that is a polylactide polymer or a copolymer of lactide and glycolide and a second absorbable polymer type that is poly(p-dioxanone), wherein the first absorbable polymer type or the second absorbable polymer type or the first absorbable polymer type and the second absorbable polymer type additionally comprise a first polymeric component and a second polymeric component. The first polymeric component has a higher weight average molecular weight than the second polymeric component and at least one of said components is at least partially end-capped by a carboxylic acid. The novel polymeric blends are useful for manufacturing medical devices having dimensional stability, having engineered degradation and breaking strength retention in vivo. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了新颖的可吸收聚合物共混物。 共混物具有第一可吸收聚合物类型，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，以及聚（对二恶烷酮）的第二可吸收聚合物类型，其中第一可吸收聚合物类型或第二可吸收聚合物类型或第一可吸收聚合物类型 可吸收聚合物类型和第二可吸收聚合物类型另外包含第一聚合物组分和第二聚合物组分。 第一聚合物组分具有比第二聚合物组分更高的重均分子量，并且至少一种所述组分至少部分地被羧酸封端。 新型聚合物共混物可用于制造具有尺寸稳定性，具有工程化降解和体内断裂强度保持性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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公开(公告)号：US09737629B2
公开(公告)日：2017-08-22
申请号：US14635170
申请日：2015-03-02
Applicant: Ethicon, Inc.
Inventor： Daniel Steiger , Dennis D. Jamiolkowski , Modesto Erneta
IPC: A61L17/12 , A61L27/26 , A61L27/54 , A61B17/064 , B29C45/00 , B29C47/00 , B29C49/00 , A61L17/00 , A61B17/06 , C08L67/04 , C08J3/00 , A61B17/00 , B29L31/00
CPC classification number: A61L17/12 , A61B17/06166 , A61B17/064 , A61B2017/00004 , A61L17/005 , A61L27/26 , A61L27/54 , A61L2300/202 , A61L2300/404 , A61L2300/606 , A61L2430/00 , B29C45/00 , B29C47/00 , B29C49/00 , B29L2031/753 , C08J3/005 , C08J2367/04 , C08J2467/04 , C08L67/04 , Y10T442/10 , Y10T442/3976 , Y10T442/40 , Y10T442/696
Abstract: Novel absorbable polymer blends are disclosed. The blends are useful for manufacturing medical devices having engineered degradation and breaking strength retention in vivo. The blends consist of a first absorbable polymeric component and a second absorbable polymeric component. The weight average molecular weight of the first polymeric component is higher than the weight average molecular weight of the second polymeric component. At least at least one of said components is at least partially end-capped by a carboxylic acid group. Further aspects are medical devices made therefrom.
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10.发明授权Absorbable polymeric blend compositions based on copolymers prepared from mono- and di-functional polymerization initiators, processing methods, and medical devices therefrom 有权基于由单功能和二官能聚合引发剂，加工方法和医疗装置制备的共聚物的可吸收聚合共混物组合物公开(公告)号：US09259514B2
公开(公告)日：2016-02-16
申请号：US14571371
申请日：2014-12-16
Applicant: Ethicon, Inc.
Inventor： Sasa Andjelic , Dennis D. Jamiolkowski , Brian M. Kelly , Christopher DeFelice , Daniel Steiger
IPC: C08G63/91 , A61L31/04 , A61L31/14 , A61L27/18 , A61L29/06 , A61L31/06 , A61L17/12 , C08L67/04 , A61B17/064 , C08G65/32 , A61B17/00
CPC classification number: A61L31/041 , A61B17/064 , A61B17/0642 , A61B2017/00004 , A61B2017/00889 , A61B2017/00893 , A61L17/12 , A61L27/18 , A61L29/06 , A61L31/06 , A61L31/148 , C08G63/664 , C08L67/04 , C08L2205/025 , C08L2205/03
Abstract: Novel absorbable polymeric blends made from components wherein at least one of the components is synthesized using mixtures of mono- and di-functional initiators are disclosed. The blends have a first component that is a polylactide polymer or a copolymer of lactide and glycolide and a second component that is either poly(p-dioxanone) homopolymer, or a poly(p-dioxanone-co-glycolide) copolymer. The novel polymeric blends provide medical devices having dimensional stability. Also disclosed are novel absorbable medical devices made from these novel polymer blends, as well as novel methods of manufacture.
Abstract translation: 公开了由组分制成的新型可吸收聚合物共混物，其中使用单官能和二官能引发剂的混合物合成至少一种组分。 共混物具有第一组分，其是聚丙交酯聚合物或丙交酯和乙交酯的共聚物，第二组分是聚（对二恶烷酮）均聚物或聚（对 - 二恶烷酮 - 共 - 乙交酯）共聚物。 新型聚合物共混物提供具有尺寸稳定性的医疗装置。 还公开了由这些新型聚合物共混物制成的新型可吸收医疗器件以及新颖的制造方法。
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