Soya extract, process for its preparation and pharmaceutical composition
    14.
    发明授权
    Soya extract, process for its preparation and pharmaceutical composition 有权
    大豆提取物,其制备方法和药物组成

    公开(公告)号:US06607757B2

    公开(公告)日:2003-08-19

    申请号:US09902226

    申请日:2001-07-11

    IPC分类号: A61K3578

    摘要: A soya extract having a content of glucoside isoflavones of at least 13% by weight and a content of 0.6 to 1.5 parts by weight of group B soya saponins per 1 part by weight of glucoside isoflavones. Also, pharmaceutical compositions containing this extract and methods of administering the extract to treat conditions such as pre- or post-menopausal symptoms, cancer, such as breast or prostrate cancer, or alcoholism. The extracts are made by a process which includes the steps of treating ripe whole soya beans or oil-free soya flour with an aliphatic alcohol to obtain a first extract; concentrating the first extract to form a concentrated first extract; purifying the concentrated first extract by treatment with at least one aliphatic hydrocarbon; and extracting active components from the purified concentrated first extract with a water-immiscible aliphatic alcohol to obtain a second extract. Preferably, the final extract is concentrated and dried to form the desired soya extract.

    摘要翻译: 含有至少13重量%的葡萄糖苷异黄酮和每1重量份葡萄糖苷异黄酮的B组大豆皂苷含量为0.6〜1.5重量份的大豆提取物。 此外,含有该提取物的药物组合物和施用提取物以治疗诸如绝经前或绝经后症状的癌症,癌症例如乳腺癌或前列腺癌或酒精中毒的方法。 提取物通过包括用脂肪醇处理成熟的大豆或无油大豆粉以获得第一提取物的步骤的方法制备; 浓缩第一提取物以形成浓缩的第一提取物; 通过用至少一种脂族烃处理纯化浓缩的第一提取物; 并用水不混溶的脂族醇从纯化的浓缩的第一提取物提取活性成分,得到第二提取物。 优选地,将最终的提取物浓缩并干燥以形成所需的大豆提取物。

    Baccatine III derivatives
    16.
    发明授权
    Baccatine III derivatives 失效
    芽胞杆菌III衍生物

    公开(公告)号:US5698712A

    公开(公告)日:1997-12-16

    申请号:US467739

    申请日:1995-06-06

    IPC分类号: C07D305/14

    CPC分类号: C07D305/14

    摘要: Isolation of a new taxane having pharmaceutical activity, 1a 14-beta-hydroxy-10-deacetyl-baccatine III and hemisynthesis of some derivatives useful as antitumor agents and intermediates.

    摘要翻译: 分离具有药物活性的新的紫杉烷,1a 14-β-羟基-10-脱乙酰基 - 杆菌肽III和用作抗肿瘤剂和中间体的一些衍生物的半合成。

    Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel
    19.
    发明授权
    Semisynthesis process for the preparation of 10 deacetyl-N-debenzoyl-paclitaxel 有权
    制备10种脱乙酰-N-去苯甲酰紫杉醇的半合成方法

    公开(公告)号:US08318957B2

    公开(公告)日:2012-11-27

    申请号:US12104715

    申请日:2008-04-17

    IPC分类号: C07D305/00

    CPC分类号: C07D413/12 C07D305/14

    摘要: A process for the preparation of 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) said process comprising: reacting 10-deacetylbaccatin III with a trichloroacetic acid activated derivative to obtain a reaction mixture, and performing an isolation step on said reaction mixture obtain purified 10-deacetyl-bis-7,10-trichloroacetylbaccatin III (VI) having a content, of corresponding 7- or 10 mono-trichloroacetyl derivatives lower than 0.1% as determined by HPLC.

    摘要翻译: 一种制备10-脱乙酰基 - 双-7,10-三氯乙酰基浆果赤霉素III(VI)的方法,所述方法包括:使10-脱乙酰基浆果赤霉素III与三氯乙酸活化的衍生物反应,得到反应混合物,并对所述反应进行分离步骤 混合物通过HPLC测定具有相应的7-或10个单三氯乙酰基衍生物低于0.1%的纯化的10-脱乙酰基 - 双-7,10-三氯乙酰基浆果赤霉素III(VI)。