公开(公告)号：US10556966B2

公开(公告)日：2020-02-11

申请号：US16170819

申请日：2018-10-25

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20170274092A1

公开(公告)日：2017-09-28

申请号：US15438418

申请日：2017-02-21

Applicant: GENENTECH, INC.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: A61K47/48 ,  C07K16/00 ,  A61K39/395 ,  C07K16/32 ,  A61K31/5517 ,  C07K19/00 ,  C07D487/16

CPC classification number: A61K31/5517 ,  A61K39/39558 ,  A61K47/6803 ,  A61K47/6855 ,  A61K47/6869 ,  C07K16/005 ,  C07K16/32 ,  C07K2317/24 ,  C07K2317/92

Abstract: The invention provides immunoconjugates comprising anti-HER2 antibodies and methods of using the same.

公开(公告)号：US20140140993A1

公开(公告)日：2014-05-22

申请号：US14166519

申请日：2014-01-28

Applicant: Genentech, Inc.

Inventor： Leanne Berry Ross ,  Gail Lewis Phillips ,  Mark X. Sliwkowski

IPC: A61K47/48 ,  G01N33/50 ,  A61K31/517 ,  A61K31/337 ,  A61K39/395 ,  A61K31/5377

Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

Abstract translation: 抗体 - 药物偶联物曲妥珠单抗-MC-DM1和化学治疗剂（包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐）的组合可用于抑制肿瘤细胞生长，以及用于治疗诸如由 HER2和KDR（VEGFR受体1）。 公开了将这些组合用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理条件中的这种疾病的方法。

公开(公告)号：US20240277838A1

公开(公告)日：2024-08-22

申请号：US18659241

申请日：2024-05-09

Applicant: GENENTECH, INC.

Inventor： Gail Lewis Phillips ,  Deepak Sampath ,  Ingrid Wertz

IPC: A61K39/395 ,  A61K31/496 ,  A61K31/635 ,  A61K39/00 ,  A61K45/06 ,  A61K47/68 ,  A61P35/00 ,  C07K16/32 ,  G01N33/574

CPC classification number: A61K39/39558 ,  A61K31/496 ,  A61K31/635 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6809 ,  A61K47/6851 ,  A61P35/00 ,  C07K16/32 ,  G01N33/57415 ,  G01N33/57446 ,  A61K2039/505 ,  A61K2300/00 ,  C07K2317/24 ,  C07K2317/73 ,  G01N2333/4703 ,  G01N2800/52

Abstract: The present invention is directed to a combination therapy involving an anti-HER2 antibody-drug conjugate and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a HER2-expressing cancer.

公开(公告)号：US20230041134A1

公开(公告)日：2023-02-09

申请号：US17720717

申请日：2022-04-14

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10898570B2

公开(公告)日：2021-01-26

申请号：US15849018

申请日：2017-12-20

Applicant: Genentech, Inc.

Inventor： Gail Lewis Phillips ,  Deepak Sampath ,  Ingrid Wertz

IPC: A61K39/395 ,  C07K16/32 ,  G01N33/574 ,  A61K47/68 ,  A61K31/635 ,  A61K45/06 ,  A61P35/00 ,  A61K31/496 ,  A61K39/00

Abstract: The present invention is directed to a combination therapy involving an anti-HER2 antibody-drug conjugate and a selective Bcl-2 inhibitor for the treatment of a patient suffering from cancer, particularly, a HER2-expressing cancer.

公开(公告)号：US20190177429A1

公开(公告)日：2019-06-13

申请号：US16170819

申请日：2018-10-25

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  G01N33/574 ,  A61K49/00 ,  A61K39/395 ,  A61K31/704 ,  A61K31/675 ,  A61K31/5517 ,  C07K16/30 ,  A61K47/68 ,  C07K16/28

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.