公开(公告)号：US20220064331A1

公开(公告)日：2022-03-03

申请号：US17341990

申请日：2021-06-08

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.

公开(公告)号：US20220033520A1

公开(公告)日：2022-02-03

申请号：US17343543

申请日：2021-06-09

Applicant: Genentech, Inc.

Inventor： Gregory A. Lazar ,  James Ernst ,  Jasvinder Atwal ,  Shraddha Shirish Sadekar ,  Yanli Yang ,  Shan Chung

IPC: C07K16/40 ,  A61P25/28 ,  C07K16/18

Abstract: Biological macromolecules have tremendous potential for the treatment of disease of the central nervous system (CNS), however, the presence of the blood brain barrier (BBB) makes achieving a therapeutically relevant antibody concentration extremely challenging. Antibodies with enhanced neutral pH affinity for the neonatal Fc receptor demonstrate improved accumulation in the brain. Variants disclosed herein also enhanced exposure in engineered mouse models. Using an anti-BACE1 antibody, these Fc variants significantly reduced the levels of brain Abeta.

公开(公告)号：US20190177432A1

公开(公告)日：2019-06-13

申请号：US16284774

申请日：2019-02-25

Applicant: GENENTECH, INC.

Inventor： Yongmei Chen ,  James Ernst ,  Hok Seon Kim ,  Junichiro Sonoda ,  Christoph Spiess ,  Scott Stawicki ,  Yan Wu

IPC: C07K16/40 ,  C07K14/71 ,  C07K16/28

Abstract: The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.