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公开(公告)号：US09845359B2
公开(公告)日：2017-12-19
申请号：US14754229
申请日：2015-06-29
申请人： Genentech, Inc.
发明人： Junichiro Sonoda , Yan Wu
IPC分类号： C07K16/28 , A61K39/395 , C07K16/40 , A61K45/06 , A61K39/00
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
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公开(公告)号：US20150218276A1
公开(公告)日：2015-08-06
申请号：US14582100
申请日：2014-12-23
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
IPC分类号： C07K16/28
CPC分类号： C07K16/40 , A61K2039/505 , C07K14/71 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/40 , C07K2317/41 , C07K2317/51 , C07K2317/515 , C07K2317/524 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/75 , C07K2317/92
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
摘要翻译： 目前公开的主题提供了结合KLB和FGFR1的抗体及其使用方法。 在某些实施方案中，本公开的抗体包括结合存在于FGFR1上并与KLB上存在的表位结合的双特异性抗体。
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公开(公告)号：US20240076388A1
公开(公告)日：2024-03-07
申请号：US18194906
申请日：2023-04-03
申请人： GENENTECH, INC.
发明人： Junichiro Sonoda , Yan Wu
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , C07K16/40
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , C07K16/28 , C07K16/40 , A61K2039/505
摘要： The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
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公开(公告)号：US20240026033A1
公开(公告)日：2024-01-25
申请号：US18194276
申请日：2023-03-31
申请人： Genentech, Inc.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
CPC分类号： C07K16/40 , C07K14/71 , C07K16/2863 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/75 , C07K2317/92 , C07K2317/40 , C07K2317/41 , C07K2317/524 , C07K2317/567 , C07K2317/71 , A61K2039/505
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20220064331A1
公开(公告)日：2022-03-03
申请号：US17341990
申请日：2021-06-08
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20190177432A1
公开(公告)日：2019-06-13
申请号：US16284774
申请日：2019-02-25
申请人： GENENTECH, INC.
发明人： Yongmei Chen , James Ernst , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Scott Stawicki , Yan Wu
摘要： The presently disclosed subject matter provides antibodies that bind KLB and FGFR1, and methods of using the same. In certain embodiments, an antibody of the present disclosure includes a bispecific antibody that binds to an epitope present on FGFR1 and binds to an epitope present on KLB.
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公开(公告)号：US20190040142A1
公开(公告)日：2019-02-07
申请号：US15974369
申请日：2018-05-08
申请人： GENENTECH, INC.
发明人： Diana Ronai Dunshee , Joanne Hongo , Hok Seon Kim , Junichiro Sonoda , Christoph Spiess , Angie Grace Yee
IPC分类号： C07K16/28
摘要： The presently disclosed subject matter relates to multispecific antibodies, e.g., bispecific antibodies and biepitopic antibodies, and methods for screening for such antibodies, and a novel antibody structure that can be used to screen for such bispecific antibodies and biepitopic antibodies. The present disclosure further provides bispecific anti-KLB antibodies and methods
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公开(公告)号：US20150376283A1
公开(公告)日：2015-12-31
申请号：US14754229
申请日：2015-06-29
申请人： GENENTECH, INC.
发明人： Junichiro Sonoda , Yan Wu
IPC分类号： C07K16/28 , A61K39/395 , C07K16/40 , A61K45/06
CPC分类号： C07K16/2863 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/28 , C07K16/40 , C07K2317/31 , C07K2317/34 , C07K2317/35 , C07K2317/56 , C07K2317/75 , C07K2317/92
摘要： The invention provides FGFR1 agonists, including agonistic anti-FGFR1 antibodies, and methods of using the same.
摘要翻译： 本发明提供FGFR1激动剂，包括激动性抗FGFR1抗体及其使用方法。
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